Antibacterial evaluation of some benzimidazole derivatives and their zinc(II) complexes

Abstract

Zinc(II) chloride was reacted with some 1-benzylbenzimidazole derivatives (L) to give complexes of the formula ZnL2Cl2. All the ligands and their zinc(II) complexes were evaluated for their in vitro antibacterial activity against Pseudomonas aeruginosa, Bacillus cereus, Staphylococcus aureus and Sarcina lutea. Themajority of the investigated compounds displayed in vitro antimicrobial activity against very persistent microorganisms. It was found that all the tested compounds were more active against gram-positive than gram-negative bacteria. The minimum inhibitory concentration (MIC) was determined for all ligands and their complexes. The effect of the structure of the ligands and complexes on the antimicrobial activity is discussed. The complexes were found to be more toxic than the ligands.

Spectral characterization and antimicrobial activity of 2-(5-chloro/nitro-1H-benzimidazol-2-yl)-4-bromo/nitro-phenols and their zinc(II) complexes

“…Antibacterial activity of 1-benzylbenzimidazole derivatives and their Zn(II) complexes was evaluated. It was found that all the tested compounds were more active against Gram-positive bacteria as compared to activities against Gram-negative bacteria [19]. Antimicrobial activity of Zn(II), Ni(II), Cu(II) and Co(II) complexes of thiabendazole against Escherichia coli, B. subtilis and A. flavues organisms was estimated.…”

The effect of lipophilicity on the antibacterial activity of some 1-benzylbenzimidazole derivatives

“…The synthesis of benzimidazoles has received a lot of attention owing to the varied biological activity exhibited by a number of these compounds. [1][2][3][4][5][6][7] This class of molecules proved to be very important, as they possess pharmaceutical properties, including antibacterial, against different strains of Gram-positive and Gram-negative bacteria, 8-10 antifungal 3 and herbicidal 11 activity. It is also well-known that these molecules are present in a variety of analgesic, 12 anti-oxidant, 13,14 anti-allergic 15,16 and antitumoral 17 agents.…”

Antibacterial activity of cobalt(II) complexes with some benzimidazole derivatives

“…Antimicrobial activities of the free ligands against the same bacteria were tested in a previous study. 8 Minimum inhibitory concentration (MIC) was determined by the agar dilution method according to guidelines established by the NCCLS standard M7-A5. 29 The MIC is described as the lowest concentration of a compound that visibly inhibited the growth of a colony.…”

“…[1][2][3][4][5][6][7] This class of compounds has been found to show antimicrobial activities against Gram-positive and Gram-negative bacteria, primarily because of the potential bio-activity of benzimidazole--based ligands. [8][9][10] Hence, the incorporation of imidazole and benzimidazole nuclei is an important synthetic strategy in drug discovery.…”