Antibacterial Flavonoids fromHelichrysum picardiiandH. italicum

Abstract

The leaves of Pluchea symphytfolia (Miller) Gilis (Asteraceae) are used by the Mixe indians (Oaxaca, Mexico) against stomach-ache, diarrhea, intestinal parasites, and externally against infections of the ear (1). Only sesquiterpenes derived from cuauthemone and thiopheneacetylenes have been isolated from this species (2). Guided by a gelatine precipitation assay, the new 1,3,4,5-tetracaffeoylquinic acid (1) and compound 2 were isolated from the EtOAc layer of an aqueous acetone extract of the air-dried aerial parts in yields of 0.3% and 0.1%, respectively. Their separation was achieved by CC on Sephadex LH-20 and on MCI-CHP 20 HP gel. The structures of 1 and 2 were established by 1H-NMR and 13C-NMR spectroscopy, including 2Dhomo and 2D-hetero NMR techniques, mass spectrometry, and by chemical degradation.

Flavonoids and terpenoids from Helichrysum forskahlii

“…Chemical studies on Helichrysum species have been carried out by many investigators and the presence of flavonoids, phloroglucinols, a-pyrones, coumarins and terpenoid compounds has been reported (Bohlmann and Abraham, 1979;Bohlmann and Misra, 1984;Jakupovic et al, 1989Jakupovic et al, , 1990Randriaminahy et al, 1992;Caffaratti et al, 1994;Matsumoto et al, 1985). In addition, some of these species have been reported to possess antimicrobially active compounds (Tomas- Barberan et al, 1988aBarberan et al, , 1988bIniesta-Sanmartin et al, 1990). In our search for biologically active compounds from Saudi plants, Helichrysum forskahlii (J.F.…”

Composition, Antioxidant Potential, and Antimicrobial Activity of Helichrysum plicatum DC. Various Extracts

“…Methoxylated flavones were, however, reported in other Helichrysum species, such as H. viscosum var. bracteatum [43], H. decumbens [29], H. foetidum [114], H. italicum [115], H. kraussii [116], H. melaleucum [102], H. nitens [42], H. odoratissimum [116], and H. picardii [115].…”

Protease-inhibiting, molecular modeling and antimicrobial activities of extracts and constituents from Helichrysum foetidum and Helichrysum mechowianum (compositae)

“…It has been also reported that Helichysum species are used to relief abdominal pain, heart burn, cough, cold, wounds, female sterility, menstrual pain [ 4 ] and to treat some diseases such as gastric [ 5 – 7 ], gastroduodenal, gastric ulcers and gastritis [ 8 ], stomach damage [ 9 , 10 ], acute hepatitis, fever, or oedema [ 11 ], diuretic, inflammatory, allergic [ 12 , 13 ]. In addition, some of these species have been reported to possess antimicrobially active compounds [ 14 – 16 ].…”