Antibacterial Galloylated Alkylphloroglucinol Glucosides from Myrtle (Myrtus communis)

Appendino, Giovanni; Maxia, L; Bettoni, Piergiorgio; Locatelli, Monica; Valdivia, Carola; Ballero, Mauro; Stavri, Michael; Gibbons, Simon; Sterner, Olov

doi:10.1021/np050462w

Cited by 46 publications

(32 citation statements)

References 13 publications

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“…It was previously reported that Myrtus communis and Rosmarinus officinalis have strong antimicrobial and antioxidant activities (Angioni et al, 2004;Appendino et al, 2006;Bonjar, 2004;Bozin et al, 2007;Moreno et al, 2006;Okamura et al, 1994;Romani et al, 2004;Rosa et al, 2003;Santoyo et al, 2005). The results obtained in the present screen are in agreement with literature data found, and justified the folkloric use.…”

Section: Discussionsupporting

confidence: 92%

Assessment of selected Yemeni medicinal plants for theirin vitroantimicrobial, anticancer, and antioxidant activities

Mothana¹,

Kriegisch

Harms

et al. 2010

Pharmaceutical Biology

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Section: Discussionsupporting

confidence: 92%

Assessment of selected Yemeni medicinal plants for theirin vitroantimicrobial, anticancer, and antioxidant activities

Mothana¹,

Kriegisch

Harms

et al. 2010

Pharmaceutical Biology

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“…The essential oils and extracts are gaining remarkable interest for their potential multipurpose use as an antioxidant (Amira et al, 2012;Serce et al, 2010), antibacterial (Appendino et al, 2006), antifungal (Cannas et al, 2013), and antiseptic (Cakir, 2004) agents. The effects of the essential oil of M. communis on the growth and survival of H. pylori were assessed and the results showed that the essential oil of this plant represented clear activity against clinical isolates of H. pylori (Deriu et al, 2007).…”

Section: Myrtus Communismentioning

confidence: 99%

Medicinal plants in the treatment ofHelicobacter pyloriinfections

Safavi

Shams-Ardakani

Foroumadi

2014

Pharmaceutical Biology

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Context: Helicobacter pylori is a small, spiral, Gram-negative bacillus that plays a role in the pathogenesis of a number of diseases ranging from asymptomatic gastritis to gastric cancer. Schedule compliance, antibiotic drug resistance, and side-effects of triple or quadruple therapy have led to research for novel candidates from plants.Objective: The purpose of this paper is to review the most potent medicinal plants of recently published literature with anti-H. pylori activity. For centuries, herbals have been used by traditional healers around the world to treat various gastrointestinal tract disorders such as dyspepsia, gastritis, and peptic ulcer disease. The mechanism of action by which these botanicals exert their therapeutic properties has not been completely and clearly elucidated. Anti-H. pylori properties may be one of the possible mechanisms by which gastroprotective herbs treat gastrointestinal tract disorders. Materials and methods: Electronic databases such as PubMed, Google scholar, EBSCO, and local databases were explored for medicinal plants with anti-H. pylori properties between 1984 and 2013 using key words ''medicinal plants'' and ''Helicobacter pylori'' or ''anti-Helicobacter pylori''. Results: A total of 43 medicinal plant species belonging to 27 families including Amaryllidaceae,

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“…Recent reports have described the anti-oxidant [6] and anti-inflammatory [7] activities of myrtle extracts. Oligomeric acylphloroglucinols were isolated from myrtle leaves and showed potent multi-drug resistant anti-bacterial effects [8,9]. Myrtucommulone, one of the acylphloroglucinols, inhibited Plasmodium growth in a nanomolar range [8], and caused a striking reduction of parasitaemia in mice infected with Plasmodium berghei [10].…”

Section: Introductionmentioning

confidence: 99%

Anti-plasmodial and insecticidal activities of the essential oils of aromatic plants growing in the Mediterranean area

Dell’Agli

Sanna

Rubiolo

et al. 2012

Malar J

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BackgroundSardinia is a Mediterranean area endemic for malaria up to the last century. During a screening study to evaluate the anti-plasmodial activity of some aromatic plants traditionally used in Sardinia, Myrtus communis (myrtle, Myrtaceae), Satureja thymbra (savory, Lamiaceae), and Thymus herba-barona (caraway thyme, Lamiaceae) were collected in three vegetative periods: before, during and after flowering.MethodsThe essential oils were obtained by steam distillation, fractionated by silica gel column chromatography and analysed by GC-FID-MS. Total oil and three main fractions were tested on D10 and W2 strains of Plasmodium falciparum in vitro. Larvicidal and adulticidal activities were tested on Anopheles gambiae susceptible strains.ResultsThe essential oil of savory, rich in thymol, was the most effective against P. falciparum with an inhibitory activity independent from the time of collection (IC50 17–26 μg/ml on D10 and 9–11 μg/ml on W2). Upon fractionation, fraction 1 was enriched in mono-sesquiterpenoid hydrocarbons; fraction 2 in thymol (73-83%); and fraction 3 contained thymol, carvacrol and terpinen-4-ol, with a different composition depending on the time of collection. Thymol-enriched fractions were the most active on both strains (IC50 20–22 μg/ml on D10 and 8–10 μg/ml on W2) and thymol was confirmed as mainly responsible for this activity (IC50 19.7± 3.0 and 10.6 ± 2.0 μg/ml on D10 and W2, respectively). The essential oil of S. thymbra L. showed also larvicidal and adulticidal activities. The larvicidal activity, expressed as LC50, was 0.15 ± 0.002; 0.21 ± 0.13; and 0.15 ± 0.09 μg/ml (mean ± sd) depending on the time of collection: before, during and after flowering, respectively.ConclusionsThis study provides evidence for the use of essential oils for treating malaria and fighting the vector at both the larval and adult stages. These findings open the possibility for further investigation aimed at the isolation of natural products with anti-parasitic properties.

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Antibacterial Galloylated Alkylphloroglucinol Glucosides from Myrtle (Myrtus communis)

Cited by 46 publications

References 13 publications

Assessment of selected Yemeni medicinal plants for theirin vitroantimicrobial, anticancer, and antioxidant activities

Assessment of selected Yemeni medicinal plants for theirin vitroantimicrobial, anticancer, and antioxidant activities

Medicinal plants in the treatment ofHelicobacter pyloriinfections

Anti-plasmodial and insecticidal activities of the essential oils of aromatic plants growing in the Mediterranean area

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