Antibacterial mechanism of Tetrastigma hemsleyanum Diels et Gilg's polysaccharides by metabolomics based on HPLC/MS

Chen, Xiao; Lan, Tao; Yi, Ruokun; Weng, Shaohuang; Zhou, C.; Wang, Jian; Guo, Longhua; Lin, Zhenyu; Pan, Wei; Qiu, Bin

doi:10.1016/j.ijbiomac.2019.08.097

Cited by 48 publications

(19 citation statements)

References 29 publications

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“…MIC value ranges from 31.3 μg/mL to 125 μg/mL. Chen ( Chen et al, 2019 ) had clarified the antibacterial mechanism of T. hemsleyanum 's polysaccharide was that it could inhibit the proliferation of E. coli by interfering with glycolysis and gluconeogenesis.…”

Section: Pharmacologymentioning

confidence: 99%

“…Hua Shi Xuan Fei mixture (Approval number of Zhejiang medicine, Z20200026000), which is mainly composed of T. hemsleyanum , has been approved by Zhejiang Provincial Drug Administration for clinical treatment of COVID-19. Futhermore, the modern pharmacological studies had shown that T. hemsleyanum also had effects of anti-inflammatory ( Ji et al, 2019 ), antioxidant ( Hossain et al, 2011 ), antivirus ( Ding et al, 2019 ), antitumor ( Lin et al, 2014 ) antipyretic ( Yang and Wang, 2014 ), anti-hepatic injury ( Ma et al, 2012 ), immunomodulatory ( Xu et al, 2008 ), anti-bacterial ( Chen et al, 2019 ), hypoglycemic ( Ru et al, 2018a , Ru et al, 2018b ) etc. Numerous reports have demonstrated that the biological activities of T. hemsleyanum are attributed to its many chemical components ( Fu et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

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A comprehensive review on traditional uses, chemical compositions, pharmacology properties and toxicology of Tetrastigma hemsleyanum

Juan

et al. 2021

Journal of Ethnopharmacology

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Ethnopharmacological relevance Tetrastigma hemsleyanum Diels et Gilg ( T.hemsleyanum ), a rare herbal plant distributed in subtropical areas of mainland China, has become a focus of scientiﬁc attention in recent years because of its high traditional value, including uses for treatment of children with fever, pneumonia, asthma, rheumatism, hepatitis, menstrual disorders, scrofula, and pharynx pain. Aim This systematic review aims to provide an insightful understanding of traditional uses, chemical composition, pharmacological effect and clinical application of T. hemsleyanum , and lay a foundation for the further study and for the utilization of T. hemsleyanum resource. Materials and methods A domestic and overseas literature search in known databases was conducted for published articles using the relevant keywords. Results One hundred and forty-two chemical constituents identified from T. hemsleyanum have been reported, including flavonoids, phenolic acids, polysaccharide, organic acids, fatty acids, terpenoids, steroids, amino acid and others. Among these components, flavonoids and polysaccharides were the representative active ingredients of T. hemsleyanum , which have been widely investigated. Modern pharmacological studies have shown that these components exhibited various pharmacological activities, such as anti-inflammatory, antioxidant, antivirus, antitumor, antipyretic, anti-hepatic injury, immunomodulatory, antibacterial etc. Moreover, different toxicological studies indicated that the clinical dosage of T. hemsleyanum was safe and reliable. Conclusions Modern pharmacological studies have well supported and clarified some traditional uses, and T. hemsleyanum has a good prospect for the development of new drugs due to these outstanding properties. However, the present findings did not provide an in-depth evaluation of bioactivity of the extracts, the composition of its active extracts was not clear. Moreover, they were insufficient to satisfactorily explain some mechanisms of action. Data regarding many aspects of T. hemsleyanum , such as links between the traditional uses and bioactivities, pharmacokinetics, quality control standard and the clinical value of active compositions is still limited which need more attention.

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Section: Pharmacologymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A comprehensive review on traditional uses, chemical compositions, pharmacology properties and toxicology of Tetrastigma hemsleyanum

Juan

et al. 2021

Journal of Ethnopharmacology

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“…The investigation has suggested that TDG polysaccharide could inhibit the growth of E. coli and possessed prominent antibacterial activity. Chen et al (2019) employ a method of metabolomics combined with HPLC/MS and find that TDG's polysaccharide interferes with the conversion of F6P to FBP and inhibits the E. coli's proliferation. Chu et al (2020) explore the protective mechanism of TDG leaves extract against ACR induced toxicities in HepG2 cells and Caenorhabditis elegans (C. elegans).…”

Section: Other Activitiesmentioning

confidence: 99%

“…The investigation has suggested that TDG polysaccharide could inhibit the growth of E. coli and possessed prominent antibacterial activity. Chen et al. (2019) employ a method of metabolomics combined with HPLC/MS and find that TDG’s polysaccharide interferes with the conversion of F6P to FBP and inhibits the E. coli’s proliferation.…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

The Phytochemistry, Pharmacology, and Quality Control of Tetrastigma hemsleyanum Diels & Gilg in China: A Review

Zhu

Ying

et al. 2020

Front. Pharmacol.

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Tetrastigma hemsleyanum Diels & Gilg (TDG), the family member of Vitaceae, is a traditional herbal medicine in China. The root of TDG can be immediately used after cleaning the muddy soil, and can be dehydrated for dry use. TDG is able to be collected all year round, which is commonly used in the treatment of hepatitis, infantile high fever, snake bite, etc. Based on phytochemistry, the chemical components of TDG are divided into flavonoids, phenolic acids, terpenes, steroids, polysaccharide, and other compounds, showing many pharmacological effects which include anti-tumor, antioxidation, anti-inflammatory, antipyretic, analgesic, and immunomodulatory activity, as well as other activities. Currently, TDG involves some problems of the reduction of wild resources, the backward processing methods, and storage difficulties as well as the imperfection of detection methods. Therefore, this review summarizes the literature of the past 20 years, and the purpose of this review is to summarize the recent researches on the phytochemistry, pharmacology, quality control, and clinical application of TDG. The above discussions provide new insights for the future research on TDG.

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“…Previous studies have shown that TH has antioxidant, anti-inflammatory, anticancer, and immunomodulatory properties that can effectively treat high fever, infantile febrile seizures, pneumonia, asthma, hepatitis, rheumatism, menstrual disorders, sore throats, and sores [21,22]. It has reported that TH contains many phytochemicals, such as flavonoids, phenolic acids, polysaccharides, and phytosterols, resulting in its various biologically activities such as anti-inflammatory, antioxidant, antiproliferative, antitumor, and antiviral effects [22][23][24]. However, there are fewer studies that paid attention to vine of TH, which is usually regarded useless and often discarded as a by-product, resulting in a waste of source.…”

Section: Introductionmentioning

confidence: 99%

Tetrastigma hemsleyanum Vine Flavone Ameliorates Glutamic Acid-Induced Neurotoxicity via MAPK Pathways

Chu

Zheng

et al. 2020

Oxidative Medicine and Cellular Longevity

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Glutamic acid (Glu) is a worldwide flavor enhancer with various positive effects. However, Glu-induced neurotoxicity has been reported less. Tetrastigma hemsleyanum (TH), a rare herbal plant in China, possesses high medicinal value. More studies paid attention to tuber of TH whereas vine part (THV) attracts fewer focus. In this study, we extracted and purified flavones from THV (THVF), and UPLC-TOF/MS showed THVF was consisted of 3-caffeoylquinic acid, 5-caffeoylquinic acid, quercetin-3-O-rutinoside, and kaempferol-3-O-rutinoside. In vitro, Glu caused severe cytotoxicity, genotoxicity, mitochondrial dysfunction, and oxidative damage to rat phaeochromocytoma (PC12) cells. Conversely, THVF attenuated Glu-induced toxicity via MAPK pathways. In vivo, the neurotoxicity triggered by Glu restrained the athletic ability in Caenorhabditis elegans (C. elegans). The treatment of THVF reversed the situation induced by Glu. In a word, Glu could cause neurotoxicity and THVF owns potential neuroprotective effects both in vitro and in vivo via MAPK pathways.

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Antibacterial mechanism of Tetrastigma hemsleyanum Diels et Gilg's polysaccharides by metabolomics based on HPLC/MS

Cited by 48 publications

References 29 publications

A comprehensive review on traditional uses, chemical compositions, pharmacology properties and toxicology of Tetrastigma hemsleyanum

A comprehensive review on traditional uses, chemical compositions, pharmacology properties and toxicology of Tetrastigma hemsleyanum

The Phytochemistry, Pharmacology, and Quality Control of Tetrastigma hemsleyanum Diels & Gilg in China: A Review

Tetrastigma hemsleyanum Vine Flavone Ameliorates Glutamic Acid-Induced Neurotoxicity via MAPK Pathways

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