Antibacterial mono- and sesquiterpene esters of benzoic acids from Iranian propolis

Trusheva, Boryana; Todorov, Ivelin; Ninova, Mariana; Najdenski, Hristo; Daneshmand, Ali; Bankova, Vassya

doi:10.1186/1752-153x-4-8

Cited by 59 publications

(47 citation statements)

References 16 publications

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“…The corresponding mass spectra were consistent with mono-and sesquiterpenyl esters of substituted benzoic acids. Very recently, we isolated several compounds of this type from a propolis sample from Iran (Trusheva et al, 2010). Using these isolated compounds as reference substances, we were able to verify the presence of ferutinin (ferutinol p-hydroxybenzoate) (3) and teferin (ferutinol vanillate) (4) in Maltese samples.…”

Section: Resultsmentioning

confidence: 74%

The specific chemical profile of Mediterranean propolis from Malta

et al. 2011

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a b s t r a c tSeventeen Maltese propolis samples were studied by GC-MS after silylation. They exhibited the typical Mediterranean chemical profile, rich in diterpene compounds (18-92% of TIC, GC-MS): 32 individual diterpenes were identified; 22 of them were present in each specimen. The other abundant compound group was that of sugars and sugar derivatives. In some samples, however, another compound group was observed (0-12% of TIC, GC-MS); the corresponding mass spectra were consistent with monoand sesquiterpenyl esters of substituted benzoic acids. Two new propolis constituents of this group, daucane diterpene esters of hydroxybenzoic acids, were isolated. Their origin is suggested to be Ferula communis, as they are taxonomic markers for this species. All propolis samples were active against Staphylococcus aureus but only those with high concentrations of terpenyl esters showed antifungal activity against Candida albicans. The present results confirm that Mediterranean propolis is a valuable natural product with potential to improve human health.

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Section: Resultsmentioning

confidence: 74%

The specific chemical profile of Mediterranean propolis from Malta

et al. 2011

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“…The Egyptians used it for embalming the body because it was the perfect plastic material that further protected the mummy from bacteria, fungi and viruses [2]. Propolis has been the subject of many studies due to its antibacterial, antifungal [3][4][5][6][7][8][9][10][11], antiviral [12--14] and hepatoprotective activity. Water-or alcoholsoluble propolis and its many compounds have been used in the treatment of inflammation, for immunostimulation [11], and as an anticancer agent.…”

Section: Introductionmentioning

confidence: 99%

The anticancer activity of propolis

Sawicka

Car

Borawska

et al. 2012

Folia Histochem Cytobiol.

172

109

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Propolis and its compounds have been the subject of many studies due to their antimicrobial and antiinflammatory activity; however, it is now known that they also possess antitumor properties. This review aims to summarize the results of studies on the mechanism of activity of propolis and its active compounds such as CAPE and chrysin in the apoptotic process, and their influence on the proliferation of cancer cells. Our review shows that propolis and its presented compounds induce apoptosis pathways in cancer cells. The antiproliferative effects of propolis, CAPE or chrysin in cancer cells are the result of the suppression of complexes of cyclins, as well as cell cycle arrest. The results of in vitro and in vivo studies suggest that propolis, CAPE and chrysin may inhibit tumor cell progression and may be useful as potential chemotherapeutic or chemopreventive anticancer drugs.

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“…In general, the composition of propolis is directly related to that of the bud exudates collected by the honeybees from various plants, and these bud exudates depend on many ecological factors [7][8][9]. Propolis exhibits some functional properties such as antibacterial, anti-inflammatory, antiviral, antioxidative, and analgesic activity and many others [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Assessment of heavy metals in propolis and soil from the Pelagonia region, Republic of Macedonia

Popov

Hristova

Presilski

et al. 2017

Maced. J. Chem. Chem. Eng.

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In this study, the contents of five representative heavy metals (Cr, Pb, Zn, Cd and Cu) were determined in soil and propolis samples from four locations in southwestern Macedonia using atomic absorption spectrometry. The aim was to pinpoint the key factors that influence the content of heavy metals in propolis and to establish whether there is a connection between the contents of heavy metals in soil and in propolis from the same location. Generally, at all of the locations, the relative concentrations of heavy metals in soil were found to decrease in the following order: Zn>Cr>Cu>Pb>Cd. The highest mean values for concentrations of heavy metals in these soils were found to be: 72. 03, 38.28, 26.64, 17.15 and 0.60 mg kg -1 for Zn, Cr, Cu, Pb and Cd, respectively, and they are all below the target values from the new Dutch list. The general trend of the heavy metal contents in propolis from the same four locations, in decreasing order, is: Pb>Cr>Zn>Cu≈Cd. Generally, the propolis samples from the highland locations (Orle and Rapeš) had lower overall contents of heavy metals than the lowland locations (Novaci and Makovo). All of the analyzed propolis samples meet the requirements of the Macedonian legislation and the international organizations for the maximum allowed levels for heavy metals. Attempts were made to find a correlation between the heavy metal contents in soil and propolis. According to our aim, the investigation presented herein offers one step towards a complete picture of ecological safety of the specific areas in the Republic of Macedonia. To do so, it is necessary to perform additional studies and to find appropriate biomonitoring methods. Further studies are needed to complete the picture and to determine the major pathways of incorporation of heavy metals in beehive products.Key words: heavy metals; soil; propolis; atomic absorption spectrometry; honeybee; biomarker ПРОЦЕНА НА ТЕШКИ МЕТАЛИ ВО ПРОПОЛИС И ВО ПОЧВА ОД ПЕЛАГОНИСКИОТ РЕГИОН, РЕПУБЛИКА МАКЕДОНИЈАВо оваа студија, со користење на атомска апсорпциона спектрометрија, беше одредена содржината на пет тешки метали (Cr, Pb, Zn, Cd и Cu) во примероци почва и прополис, од четири локации во југозападниот дел на Македонија. Целта беше да се посочат клучните фактори кои влијаат на содржината на тешките метали во почвата и во прополис од иста локација. Општо земено, на сите локации релативните концентрации на тешки метали во почва беа со следниот опаѓачки редослед: Zn>Cr>Cu>Pb>Cd. Највисоките средни вредности од концентрациите на тешки метали во овие почви изнесуваат: 72,03; 38,28; 26,64; 17,15;0,60 mg kg -1 за Zn, Cr, Cu, Pb и Cd, соодветно, и сите тие се под целните вредности претставени во Холандската листа. Општиот тренд на содржината на тешки метали во прополисот од истите четири локации, е со следниот B. Bogdanova Popov, V. Karapetkovska Hristova, S. Presilski,M. A. Shariati, S. Najman Maced. J. Chem. Chem. Eng. 36(1), 23-33 (2017) 24 опаѓачки редослед: Pb>Cr>Zn>Cu≈Cd. Генерално, примероците од прополис од планинските локации (Орле и Ра...

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Antibacterial mono- and sesquiterpene esters of benzoic acids from Iranian propolis

Cited by 59 publications

References 16 publications

The specific chemical profile of Mediterranean propolis from Malta

The specific chemical profile of Mediterranean propolis from Malta

The anticancer activity of propolis

Assessment of heavy metals in propolis and soil from the Pelagonia region, Republic of Macedonia

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