The specific chemical profile of Mediterranean propolis from Malta

Popova, Milena; Trusheva, Boryana; Antonová, Daniela; Cutajar, Simone; Mifsud, David; Farrugia, Claude; Tsvetkova, Iva; Najdenski, Hristo; Bankova, Vassya

doi:10.1016/j.foodchem.2010.11.130

Cited by 76 publications

(62 citation statements)

References 23 publications

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“…is low, like that observed in other Mediterranean propolis from Malta, whose bioactive properties were ascribed to its high concentration of diterpenes (Popova et al, 2011).…”

Section: Accepted Manuscriptmentioning

confidence: 53%

Bioactive properties of a propolis-based dietary supplement and its use in combination with mild heat for apple juice preservation

Luis-Villaroya

Espina

García-Gonzalo

et al. 2015

International Journal of Food Microbiology

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This study characterizes the antioxidant and antibacterial properties of a propolis-based dietary supplement (PDS) and investigates its incorporation into apple juice to decrease the intensity of the heat treatment required to inactivate 5 log10 cycles of Escherichia coli O157:H7. As the source of propolis, we used a PDS containing 0.2 mg/μL of propylene glycol-extracted propolis (propolis). The total phenolic content and antioxidant activity (IC50) of the PDS were 82.15±3.53 mg/g and 0.055±0.003 mg/mL, respectively. Regarding antimicrobial activity, propolis (0.2 mg/mL) was very effective under acidic pH against Listeria monocytogenes EGD-e, inactivating more than 5 log10 cell cycles in 1h, but hardly inactivated or sub-lethally injured E. coli O157:H7 Sakai. However, incorporating propolis (0.2 mg/mL) into acidic buffer decreased the time needed to inactivate 5 log10 cycles of E. coli O157:H7 Sakai at 51 °C by more than 40 times. Moreover, when combined with heat in apple juice, propolis (0.1mg/mL) reduced the thermal treatment time and temperature needed to inactivate 5 log10 cycles of E. coli by 75% and 3 °C, respectively. The corresponding PDS concentration did not decrease the organoleptic properties of the apple juice, which implies the possibility of obtaining a sensorially appealing, low-pasteurized apple juice with the functional properties provided by propolis.

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“…is low, like that observed in other Mediterranean propolis from Malta, whose bioactive properties were ascribed to its high concentration of diterpenes (Popova et al, 2011).…”

Section: Accepted Manuscriptmentioning

confidence: 53%

Bioactive properties of a propolis-based dietary supplement and its use in combination with mild heat for apple juice preservation

Luis-Villaroya

Espina

García-Gonzalo

et al. 2015

International Journal of Food Microbiology

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“…Both contain substances rarely or never reported for green propolis, such as flavonoid glycosides (e.g., 81 , 88 , and 97 ; Table 4). They also contain or share diterpenes, such as 17 and 23 (Table 4), a class of substances known to occur in Brazilian propolis [43, 56, 57] and abundant in Mediterranean propolis [20, 58]. …”

Section: Resultsmentioning

confidence: 99%

Comparative Chemistry of Propolis from Eight Brazilian Localities

Righi

Negri

Salatino

2013

Evidence-Based Complementary and Alternative Medicine

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Propolis is a complex honeybee product with resinous aspect, containing plant exudates and beeswax. Their color, texture, and chemical composition vary, depending on the location of the hives and local flora. The most studied Brazilian propolis is the green (alecrim-do-campo) type, which contains mainly prenylated phenylpropanoids and caffeoylquinic acids. Other types of propolis are produced in Brazil, some with red color, others brown, grey, or black. The aim of the present work was to determine the chemical profiles of alcohol and chloroform extracts of eight samples of propolis, corresponding to six Brazilian regions. Methanol and chloroform extracts were obtained and analyzed by HPLC/DAD/ESI/MS and GC/MS. Two chemical profiles were recognized among the samples analyzed: (1) black Brazilian propolis, characterized chiefly by flavanones and glycosyl flavones, stemming from Picos (Piauí state) and Pirenópolis (Goiás state); (2) green Brazilian propolis, characterized by prenylated phenylpropanoids and caffeoylquinic acids, stemming from Cabo Verde (Bahia state), Lavras and Mira Bela (Minas Gerais state), Pariquera-Açu and Bauru (São Paulo state), and Ponta Grossa (Paraná state). The present work represents the first report of prenylated flavonoids in Brazilian propolis and schaftoside (apigenin-8-C-glucosyl-6-C-arabinose) in green propolis.

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“…Estudos anteriores sobre a própolis brasileira têm demonstrado que existe uma variação muito grande na composição, tanto qualitativa como quantitativa dos compostos fenólicos. 16 A variação qualitativa da composição pode ser observada em análises feitas por cromatografia gasosa acoplada à espectrometria de massas -CG-MS, onde foram identificados diterpenos em amostras de própolis do Mediterrâneo e do Brasil, 17,18 e isoflavonas em amostras do Brasil. 19 Ácidos fenólicos e flavonoides foram identificados por cromatografia líquida acoplada à espectrometria de massas (LC-MS) em amostras de própolis do Brasil e da China.…”

Section: Introductionunclassified

Constituintes fenólicos e atividade antioxidante da geoprópolis de duas espécies de abelhas sem ferrão amazônicas

Silva¹,

Muniz²,

Nunomura³

et al. 2013

Quím. Nova

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Recebido em 13/6/12; aceito em 4/12/12; publicado na web em 12/3/13 PHENOLIC CONSTITUENTS AND ANTIOXIDANT ACTIVITY OF GEOPROPOLIS FROM TWO SPECIES OF AMAZONIAN STINGLESS BEES. We investigated the phenolic constituents and antioxidant activity of geopropolis from two species of stingless Amazonian bees, Melipona interrupta and Melipona seminigra. The chemical investigation of geopropolis from Melipona interrupta led to the isolation of 5,7,4'-trihydroxyflavonone, 3,5,6,7,4'-pentahydroxyflavonol, naringenine-4'-O-β-D-glucopyranoside and myricetin-3-O-β-D-glucopyranoside. Their structures were assigned based on spectroscopic analyses, including two-dimensional NMR techniques. Antioxidant activity of methanol and ethanol extracts of M. interrupta and M. seminigra were measured using the 1,2-diphenyl-2-picryl-hydrazyl (DPPH) free radical scavenging assay. This is also the first work reporting the chemical investigation of stingless bee species from the Amazonian region.Keywords: flavonoides; geopropolis; Melipona. INTRODUÇÃOA geoprópolis é um produto resinoso produzido pelas abelhas, inclusive pelas espécies Melipona interrupta e Melipona seminigra, a partir da coleta de resinas vegetais, óleos essenciais, pólen, cera e açúcares, que é utilizado na construção e calafetação da colmeia. 1,2Tem cor variada de verde, vermelho para marrom escuro, apresenta um aroma característico e propriedades adesivas, porque interage fortemente com óleos e proteínas da pele. 3Tem sido utilizada na medicina popular há milhares de anos, devido às propriedades biológicas que a própolis tem, tais como, anti-inflamatória, antibacteriana, 4,5 antifúngica, 6 antioxidante, [7][8][9] hepato-protetora, antiviral, capacidade de aumentar a resistência natural do corpo a infecções e tratar úlcera gastroduodenal. 10 Vários estudos registraram que a atividade biológica da própolis depende da composição química, a qual também depende da diversidade geográfica e da variedade genética da rainha. 11Como a própolis apresenta várias atividades biológicas, em sua composição química constam muitos produtos naturais bioativos como polifenóis, flavonoides e ésteres do ácido cafeico. 12,13 É extremamente difícil identificar qual a substância responsável por sua atividade terapêutica, uma vez que existe uma diversidade muito grande de componentes presentes na própolis. Alguns autores afirmam que sua eficácia estaria justamente na composição química heterogênea.14 Entre os grupos biologicamente ativos mais importantes descritos na própolis, estão os compostos fenólicos, onde podemos destacar os ácidos gálico, vanílico, ferúlico, p--cumárico, éster fenetílico do ácido cafeico (CAPE), ácidos cafeico e siringíco, que são comuns em produtos apícolas. 15 Outro grupo de compostos fenólicos encontrado na própolis são os flavonoides. Dentre eles podemos destacar alguns flavonóis: galangina, campeferol, quercetina, miricetina, algumas flavonas: crisina, apigenina, luteolina, tectocrisina, e as flavanonas: pinocembrina, isosacuranetina, naringenina. 10A composição química ...

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The specific chemical profile of Mediterranean propolis from Malta

Cited by 76 publications

References 23 publications

Bioactive properties of a propolis-based dietary supplement and its use in combination with mild heat for apple juice preservation

Bioactive properties of a propolis-based dietary supplement and its use in combination with mild heat for apple juice preservation

Comparative Chemistry of Propolis from Eight Brazilian Localities

Constituintes fenólicos e atividade antioxidante da geoprópolis de duas espécies de abelhas sem ferrão amazônicas

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