Antibacterial Nitric Oxide‐Releasing Polyester for the Coating of Blood‐Contacting Artificial Materials

Seabra, Amedea B.; Martins, Dorival; Simões, Maíra M.S.G.; Silva, Regiane da; Brocchi, Marcelo; Oliveira, Marcelo Ganzarolli de

doi:10.1111/j.1525-1594.2010.00998.x

Cited by 86 publications

(64 citation statements)

References 35 publications

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“…30,38 For example, S-nitrosothiol-modified polyesters were effective at reducing platelet adhesion/activation and had antimicrobial effect against Staphylococcus aureus and the multi-drug resistant Pseudomonas aeruginosa strains, but the NO release capability was significantly influenced by ethylene oxide sterilization. 39,40 In addition, most of the NO-releasing materials reported to date have been tested in vitro or in short-term animal models for their hemocompatibility properties, so testing these materials in longerterm animal models would be beneficial to evaluate more clinically relevant situations.…”

Section: Introductionmentioning

confidence: 99%

Reduction in thrombosis and bacterial adhesion with 7 day implantation of S-nitroso-N-acetylpenicillamine (SNAP)-doped Elast-eon E2As catheters in sheep

et al. 2015

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Thrombosis and infection are two common problems associated with blood-contacting medical devices such as catheters. Nitric oxide (NO) is known to be a potent antimicrobial agent as well as an inhibitor of platelet activation and adhesion. Healthy endothelial cells that line the inner walls of all blood vessels exhibit a NO flux of 0.5~4×10 −10 mol cm −2 min −1 that helps prevent thrombosis. Materials with a NO flux that is equivalent to this level are expected to exhibit similar anti-thrombotic properties. In this study, NO-releasing catheters were fabricated by incorporating S-nitroso-N-acetylpenicillamine (SNAP) in the Elast-eon E2As polymer. The SNAP/E2As catheters release physiological levels of NO for up to 20 d, as measured by chemiluminescence. Furthermore, SNAP is stable in the E2As polymer, retaining 89% of the initial SNAP after ethylene oxide (EO) sterilization. The SNAP/E2As and E2As control catheters were implanted in sheep veins for 7 d to examine the effect on thrombosis and bacterial adhesion. The SNAP/E2As catheters reduced the thrombus area when compared to the control (1.56 ± 0.76 and 5.06 ± 1.44 cm 2 , respectively). A 90% reduction in bacterial adhesion was also observed for the SNAP/E2As catheters as compared to the controls. The results suggest that the SNAP/E2As polymer has the potential to improve the hemocompatibility and bactericidal activity of intravascular catheters, as well as other blood-contacting medical devices (e.g., vascular grafts, extracorporeal circuits).

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Section: Introductionmentioning

confidence: 99%

Reduction in thrombosis and bacterial adhesion with 7 day implantation of S-nitroso-N-acetylpenicillamine (SNAP)-doped Elast-eon E2As catheters in sheep

et al. 2015

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“…The NO release profile from lowmolecular-weight NO donors in a biological medium may vary from a few seconds to days [12,20,21]. Therefore, the great variety of available NO donors allows for the exploration of different biochemical responses, ranging from the promotion of local vasodilation to cytotoxic effects [22,23,24].…”

Section: No Donorsmentioning

confidence: 99%

Nitric Oxide Releasing Nanomaterials for Cancer Treatment: Current Status and Perspectives

Seabra¹,

Lima²,

Calderón

2015

CTMC

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Nitric oxide (NO) is known to have dichotomous effects on cancer biology, acting as a pro- or antineoplastic agent. Low concentrations of NO are reported to promote tumor growth, whereas high NO influx acts as a potent tumor repressor, leading to cytotoxicity and apoptosis. There is increasing interest in developing NO-releasing materials as potent tumoricidal agents in which high and localized concentrations of NO may be directly released in a sustained manner to the tumor site. Nanomaterials allied to NO donors have emerged as a promising strategy in cancer treatment. In this context, this review summarizes the roles of NO in cancer biology and highlights the therapeutic potential effects of NO-releasing nanomaterials based on polymeric nanoparticles, dendritic polymers, liposomes, silica nanoparticles, metallic nanoparticles and quantum dots in combating tumor cells.

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“…30, 38 For example, S- nitrosothiol-modified polyesters were effective at reducing platelet adhesion/activation and had antimicrobial effect against Staphylococcus aureus and the multi-drug resistant Pseudomonas aeruginosa strains, but the NO release capability was significantly influenced by ethylene oxide sterilization. 39, 40 In addition, most of the NO-releasing materials reported to date have been tested in vitro or in short-term animal models for their hemocompatibility properties, so testing these materials in longer-term animal models would be beneficial to evaluate more clinically relevant situations.…”

Section: Introductionmentioning

confidence: 99%

Multivalent manganese complex decorated amphiphilic dextran micelles as sensitive MRI probes

Yang

et al. 2015

J. Mater. Chem. B

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Thrombosis and infection are two common problems associated with blood-contacting medical devices such as catheters. Nitric oxide (NO) is known to be a potent antimicrobial agent as well as an inhibitor of platelet activation and adhesion. Healthy endothelial cells that line the inner walls of all blood vessels exhibit a NO flux of 0.5~4×10−10 mol cm−2 min−1 that helps prevent thrombosis. Materials with a NO flux that is equivalent to this level are expected to exhibit similar anti-thrombotic properties. In this study, NO-releasing catheters were fabricated by incorporating S-nitroso-N-acetylpenicillamine (SNAP) in the Elast-eon E2As polymer. The SNAP/E2As catheters release physiological levels of NO for up to 20 d, as measured by chemiluminescence. Furthermore, SNAP is stable in the E2As polymer, retaining 89% of the initial SNAP after ethylene oxide (EO) sterilization. The SNAP/E2As and E2As control catheters were implanted in sheep veins for 7 d to examine the effect on thrombosis and bacterial adhesion. The SNAP/E2As catheters reduced the thrombus area when compared to the control (1.56 ± 0.76 and 5.06 ± 1.44 cm2, respectively). A 90% reduction in bacterial adhesion was also observed for the SNAP/E2As catheters as compared to the controls. The results suggest that the SNAP/E2As polymer has the potential to improve the hemocompatibility and bactericidal activity of intravascular catheters, as well as other blood-contacting medical devices (e.g., vascular grafts, extracorporeal circuits).

show abstract

Antibacterial Nitric Oxide‐Releasing Polyester for the Coating of Blood‐Contacting Artificial Materials

Cited by 86 publications

References 35 publications

Reduction in thrombosis and bacterial adhesion with 7 day implantation of S-nitroso-N-acetylpenicillamine (SNAP)-doped Elast-eon E2As catheters in sheep

Reduction in thrombosis and bacterial adhesion with 7 day implantation of S-nitroso-N-acetylpenicillamine (SNAP)-doped Elast-eon E2As catheters in sheep

Nitric Oxide Releasing Nanomaterials for Cancer Treatment: Current Status and Perspectives

Multivalent manganese complex decorated amphiphilic dextran micelles as sensitive MRI probes

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