Antibacterial phloroglucinols derivatives from the leaves of Mallotus oppositifolius (Geisler) Müll. Arg. (Euphorbiaceae)

Tchangoue, Yvan Anderson Ngandjui; Tchamgoue, Joseph; Lunga, Paul Keilah; Knepper, Janosch; Păltinean, Ramona; Ibrom, Kerstin; Crișan, Gianina; Kouam, Siméon F.; Ali, Muhammad; Schulz, Stefan

doi:10.1016/j.fitote.2020.104527

Cited by 9 publications

(10 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, ten new chromene derivatives, malloapeltas C-H (12)(13)(14)(15)(16)(31)(32) and one known compound, malloapelta B (26) were isolated from the leaves of M. apelta. All compounds were evaluated for cytotoxic activity using cell counting kit-8 (CCK-8) assay against ovarian cancer cell line (TOV-21G).…”

Section: Cytotoxic and Antitumor Activitiesmentioning

confidence: 99%

“…In 2013, Harinantenaina et al isolated three phloroglucinols, mallotophenone (112), mallotojaponin B (126), and mallotojaponin C (140) from the leaves of M.oppositifolius, and evaluated cytotoxic activity on human ovarian cancer (A2780) cell line. Compounds 112, 126, and 140 showed significant cytotoxic activity against the A2780 human ovarian cancer cell line (IC 50 6.3±0.4, 1.10±0.05, and 1.3±0.1 µM, respectively) [15,51]. Recently, five prenylflavonoids, 6-prenylnaringenin (52), 7-O-methyl-6-prenylnaringenin (53), 4′-O-methyl-6prenylnaringenin (54), 7-O-methyl-8-prenylnaringenin (55), and 8-prenylnaringenin (59) obtained from M. conspurcatus exhibited cervical cancer (HeLa) cells with IC 50 values ranging from 10.08 to 60.16 µM [29].…”

Section: Cytotoxic and Antitumor Activitiesmentioning

confidence: 99%

“…In 2018, eight compounds, 3,4,8,9,10-pentahydroxydibenzo[b,d]pyran-6-one (15), gallic acid (141), methyl gallate (142), corilagin (170), repandinin B (183), mallophenol A (149), (+)lyoniresinol-3α-O-α-L-rhamnopyranoside (196), and (Z)-3-hexenyl-β-D-glucopyranoside (324) were isolated from the active fractions of M. furetianus. Compounds 149, 196, and 324 revealed potent anti-steatosis activities in the oleic acid (OA)-induced steatosis cell model, with the minimum effective concentration of 0.05, 0.0005 and 0.0005 µg/mL, respectively, which were much lower than the positive control, fibrate (72.4 µg/mL).…”

Section: Antioxidant and Hepatoprotective Activitiesmentioning

confidence: 99%

“…In 2020, acronyculatin S (110), acronyculatin T (210), mallotojaponin C (140), and bergenin (155) were reported from the leaves of M. oppositifolius and showed inhibitory activity against the bacterial strains E. coli, S. aureus, S. typhi, P. aeruginosa with MIC values ranging from 3.125 to 50 µg/mL [15].…”

Section: Antibacterial and Antifungal Activitiesmentioning

confidence: 99%

See 3 more Smart Citations

Genus mallotus (euphorbiaceae): a review on traditional medicinal use, phytochemistry and biological activities

Anh

Park

Trang³

et al. 2022

Vietnam J. Sci. Technol.

View full text Add to dashboard Cite

Ethnopharmacological relevance: The genus Mallotus (Euphorbiaceae family) includes 124 accepted names and distributes in tropical and sub-tropical regions. Some Mallotus species are used in traditional medicines for the treatment of chronic hepatitis, enteritis stomach, disorders, cholelithiasis, anti-cancer, gastric, and duodenal ulcers. Aim of the study: According to the Scifinder database, this is the first review study that focuses on the phytochemistry and pharmacology of Mallotus genus (17 Mallotus species) to understand the link between the traditional medicinal uses, phytochemistry, and bioactivities. Thus, they provides a scientific fundamental for further research in the phytochemical and pharmacological activities of their species. Materials and methods: Information about the Mallotus genus was collected using various databases, such as Web of Science, SciFinder, PubMed, Sci-hub, Google Scholar, Wiley, Elsevier, ACS publications, and SpringerLink between 1978 and 2021. Plant names were validated by “The Plant List” (www.theplantlist.org). Results: Up to now, total 325 compounds were reported from Mallotus species, including phloroglucinols, steroids, coumarins, benzopyrans, flavonoids, chalcones, galics, and bergenins. The extracts and phytochemical constituents of the Mallotus genus are a rich source of biologically active, including anti-cancer, anti-inflammatory, immunoregulatory, antioxidant, antibacterial, antifungal, anti-virus, and other activities. Conclusions: The review indicated that the Mallotus genus is a promising source of biological activities compounds, special anti-cancer chromanes. The results of this review confirm the great potential of Mallotus species. Thus, it will be helpful for further research in the phytochemistry and pharmacology of the Mallotus genus.

show abstract

Section: Cytotoxic and Antitumor Activitiesmentioning

confidence: 99%

Section: Cytotoxic and Antitumor Activitiesmentioning

confidence: 99%

Section: Antioxidant and Hepatoprotective Activitiesmentioning

confidence: 99%

Section: Antibacterial and Antifungal Activitiesmentioning

confidence: 99%

See 2 more Smart Citations

Genus mallotus (euphorbiaceae): a review on traditional medicinal use, phytochemistry and biological activities

Anh

Park

Trang³

et al. 2022

Vietnam J. Sci. Technol.

View full text Add to dashboard Cite

show abstract

“…Amongst these drugs, 74% were isolated from medicinal plants during phytochemical studies [ 9 ]. Thus, in our previous studies some phloroglucinols, including mallotojaponin B, were isolated from Mallotus oppositifolius and shown to possess interesting antibacterial activities [ 10 ]. Since combinatory therapy is one of the approaches in designing a new drug, the combination of natural compounds between them or with available antibiotics would be an appropriate means to fight against multi-resistant bacteria [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Potentiation effect of mallotojaponin B on chloramphenicol and mode of action of combinations against Methicillin-resistant Staphylococcus aureus

et al. 2023

View full text Add to dashboard Cite

Staphylococcus aureus, the causative agent of many infectious diseases has developed resistance to many antibiotics, even chloramphenicol which was the essential antibiotic recommended for the treatment of bacterial infection. Thus, other alternatives to fight against S. aureus infections are necessary; and combinatory therapy of antibiotics with natural compounds is one of the approaches. This study evaluated the activity of the combination of mallotojaponin B and chloramphenicol against Methicillin-resistant Staphylococcus aureus (MRSA). Antibacterial activities were evaluated by broth microdilution and the checkerboard methods. Modes of action as time-kill kinetic, Nucleotide leakage, inhibition and eradication of biofilm, and loss of salt tolerance were evaluated. Cytotoxicity was evaluated on Vero and Raw cell lines. Mallotojaponin B showed good activity against MRSA with a MIC value of 12.5 μg/mL. MRSA showed high resistance to chloramphenicol (MIC = 250 μg/mL). The combination produced a synergistic effect with a mean FICI of 0.393. This combination was bactericidal, inducing nucleotide leakage, inhibiting biofilm formation, and eradicating biofilm formed by MRSA. The synergic combination was non-cytotoxic to Vero and Raw cell lines. Thus, the combination of mallotojaponin B and chloramphenicol could be a potential alternative to design a new drug against MRSA infections.

show abstract

Comprehensive Phytochemical Profile of Leaves, Stems and Fruits from Orthopterygium huaucui (A. Gray) Hemsl. and their Antioxidant Activities

Hernández,

Castañeta,

Simirgiotis

et al. 2024

Chemistry & Biodiversity

View full text Add to dashboard Cite

Orthopterygium huaucui, commonly known as "Pate", is a medicinal shrub belonging to the Anacardiaceae family used locally to treat burns and stomach pains. Endemic to Peru, chemical studies on O. huaucui are limited. In this study, UHPLC/ESI/MS/MS was used to identify secondary metabolites in leaves, stems and fruits, and the antioxidant capacities of the different parts were compared. In addition, several compounds such as methyl gallate, gallic acid, kaempferol, quercetin, and quercetin 3‐O‐β‐glucuronide were successfully isolated from the methanolic extract of the leaves of this species for the first time. Untargeted UHPLC Q/Orbitrap/ESI/MS/MS analysis tentatively identified seventy‐six compounds in the different parts of the plant, showing that this species as an interesting source of flavonoids, procyanidins and tannins. The phenolic content in leaves and stems was 334.31±4.34 and 295.18±6.38 gallic acid equivalents/100 g dry plant, respectively, while that of fruits was lower (99.92±5.45 mg/100 g). Leaves had twice the flvonoid content than fruits (210.38±3.85 versus 87.42±3.85 quercetin equivalents/100 g). DPPH) results indicated high antioxidant activity in all parts, with stems and leaves showing IC50 of 12.8 µg/mL, and fruits showing less activity (IC50 = 38.6 µg/mL). ORAC test showed higher antioxidant values in the stems (467.82±21.17 μmol Trolox equivalents/100 g).

show abstract

Antibacterial phloroglucinols derivatives from the leaves of Mallotus oppositifolius (Geisler) Müll. Arg. (Euphorbiaceae)

Cited by 9 publications

References 33 publications

Genus mallotus (euphorbiaceae): a review on traditional medicinal use, phytochemistry and biological activities

Genus mallotus (euphorbiaceae): a review on traditional medicinal use, phytochemistry and biological activities

Potentiation effect of mallotojaponin B on chloramphenicol and mode of action of combinations against Methicillin-resistant Staphylococcus aureus

Comprehensive Phytochemical Profile of Leaves, Stems and Fruits from Orthopterygium huaucui (A. Gray) Hemsl. and their Antioxidant Activities

Contact Info

Product

Resources

About