Antibacterial Polyketides from the Jellyfish-Derived Fungus <i>Paecilomyces variotii</i>

Liu, Juan; Li, Famei; Kim, Eun La; Li, Jian Lin; Hong, Jongki; Bae, Kyung Sook; Chung, Hae Young; Kim, Hyung Sik; Jung, Jee H.

doi:10.1021/np200350b

Cited by 60 publications

(49 citation statements)

References 19 publications

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“…The antimicrobial activity of the methanol crude extract from marine-derived Paecilomyces sp. was determined for MRSA, Escherichia coli, A. hydrophila and C. albicans at 18, 6, 9 and 7 mm, respectively (Liu et al, 2011). Ethyl acetate extract of P. variotii FEL24 presented antimicrobial activities ranged from 19 to 35 mm (Silva et al, 2011).…”

Section: Determination Of the Appropriate Solvent(s) For Extraction Omentioning

confidence: 99%

“…These compounds showed inhibitory activity against pathogenic bacteria, including methicillin-resistant Staphylococcus aureus 3089 and multi-drug-resistant Vibrio parahemolyticus 7001 (Liu et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

“…In the continuous search for additional bioactive metabolites, a naturally occurring anacardic acid analogue was isolated from the same fungal strain showing cytotoxicity against human and antimicrobial activity against marine pathogens Escherichia coli DC2 and Streptococcus iniae FP5228 (Liu et al, 2012). Hyung et al, (2013) suggested that the viriditoxin (10) extract from marine P. variotii is effective for preventing and treating infections caused by fish pathogenic microorganisms, particularly Aeromonas hydrophila, A.…”

Section: Introductionmentioning

confidence: 99%

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Bioactive Betulin produced by marine Paecilomyces WE3-F

Barakat¹,

Saleh²

2016

J App Pharm Sci

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Objective: Marine fungi play an important role in human and animal health, leading compounds to new drug discoveries and prospects for their bioactivity potential. Materials and Methods: Paecilomyces WE3-F was isolated from marine sediment (Red Sea, Shalateen, Egypt). Fungal isolate was screened for their antagonistic activity against four Gram-positive (Bacillus cereus, Lesteria monocytogenes, Micrococcus luteus and Staphylococcu aureus) and four Gram-negative (Aeromonas hydrophila, Flavobacteruim sp, Pseudomonas aeruginosa and Vibrio cholera,) pathogenic bacteria. Paecilomyces WE3-F was identified using 18S rRNA technology. Seven factors were chosen to be screened for bioactivity using the Placket Burman experimental design: sucrose, yeast extract, Na NO3, temperature, initial pH, inoculum size, and incubation period. Results: Among conditional factors, acidic pH and 1.5 ml inoculum size favored the bioactive metabolites. Furthermore, a number of solvents have been experimented for the extraction of the bioactive metabolite(s). Dichloromethane (DCM) crude extract from the fermentation broth of a marine Paecilomyces WE3-F showed the highest activity with averages of 26 and 24 mm against G-ve and G+ve, respectively. Under optimal culture conditions, the maximum extractable compound concentration in a 10-L culture medium reached 83.4 mg/L. Based on data obtained by thin layer chromatogram (TLC), gas chromatography -mass spectrum (GC-MS) and Fourier Transform Infrared (FTIR) the major compound, betulin was structurally identified. Conclusions:The isolated marine Paecilomyces WE3-F, therefore, showed the ability to produce a betulin yield after optimal operating conditions for antibacterial potential.

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Section: Determination Of the Appropriate Solvent(s) For Extraction Omentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Bioactive Betulin produced by marine Paecilomyces WE3-F

Barakat¹,

Saleh²

2016

J App Pharm Sci

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“…The new compound showed cytotoxicity against human and marine pathogens, including multidrug-resistant strains. Liu et al reported that this natural analogue also exhibits mild antibacterial activity against Escherichia coli DC2, Streptococcus iniae FP5228, and methicillin-resistant S. aureus (MRSA) [47].…”

Section: An Anacardic Acid Analoguementioning

confidence: 99%

The Chemical Diversity of the Ascomycete Fungus Paecilomyces variotii

Mioso

Marante

Laguna

2015

Appl Biochem Biotechnol

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Paecilomyces variotii isolated from a broad range of habitats drives the diversification of new high-value-added secondary metabolites that could potentially play an important role in human and animal health. These metabolites include the anhydride metabolite of the nonadride family, as well as the following compounds: naphthopyranone metabolites, sphingofungins, eicosenoic acids, new branched fatty acids, ascofuranone, polyketides, an anacardic acid analogue, straight-chain peptides, and volatile compounds. These natural products show that P. variotii can provide leading compounds for new drug discoveries, which may include herbicide agents, some of which are important in the agrochemical market. Finally, this review outlines recent developments, trends, and prospects for the chemistry of this ascomycete.

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“…Ecological interactions have been evolved not only between the host and their endozoic microorganisms, but also between the encozoic bacteria and fungi, which share a common substrate in either a symbiotic or competitive manner [1,2]. Unlike free-living microorganisms, encozoic microorganisms produce unique secondary metabolites in a special ecological niche, which deliver interesting pharmacological properties.…”

Section: Introductionmentioning

confidence: 99%