Antibacterial Potential Of Ethanol Extract Of Tamarind Seed Bark (Tamarindus indica L.) And Formulation Of Anti-Acne Nanogel

Abstract

Acne is a skin disease that affects a large number of sufferers. Acne occurs due to active oil glands under the skin. This activity is stimulated by androgen hormones. The active compound content of proanthocyanidin is the main compound in the ethanolic extract of tamarind seed bark, which can inhibit the growth of acne-causing bacteria, namely Propionibacterium acnes and Staphylococcus epidermidis. The purpose of this study was to formulate a nanogel from tamarind seed bark extract and test the antibacterial potential of an ethanol extract of tamarind seeds against acne-causing bacteria. The antibacterial potency test consisted of variations in concentration and was 0.5, 1, 5, 25, 50, 75, 100, 125, 150, and 300 (in mg/mL). The concentration of the formulated nanogel preparations was 2.5%, 5%, and 7.5%. The MIC results showed that the minimum inhibitory concentration (MIC) was at a concentration of 1 mg/mL with a zone of inhibition of 6.50 ± 0.44 mm (Propionibacterium acnes) and 6.40 ± 0.10 mm (Staphylococcus epidermidis). The minimum bactericidal concentration (MBC) was at a concentration of 25 mg/mL with a percentage reduction of 98.18% (Propionibacterium acnes) and 98.06% (Staphylococcus epidermidis). The results of the nanogel formulations showed that the particle sizes were 49.88 ± 0.11 nm (Formula I), 51.92 ± 0.09 nm (Formula II), and 59.13 ± 0.10 nm (Formula III). Conclusion The ethanolic extract of tamarind seed bark has effectiveness in inhibiting the growth of acne-causing bacteria and can be formulated as an anti-acne nanogel.

Antifungal activity testing of curry leaf ethanol extract on the growth of Pityrosporum ovale and Candida albicans fungus

“…18 The findings of this study are consistent with earlier studies demonstrating the presence of the same secondary Sari UP et al Int J Basic Clin Pharmacol. 2024 Jan;13 (1):57-63 metabolites in curry leaves as the subject of this investigation. The state of the fertilizer, the age of the sample plants utilized, the location of the plants, and the state of the soil where they are grown are some of the variables that can affect the results of secondary metabolite screening.…”

“…The antifungal activity is classified as having low sensitivity if the diameter measures 6-9 mm, medium sensitivity if the diameter falls between 9-12 mm, and high sensitivity if the inhibition zone exceeds 12 mm. 1,24,25 Minimum kill concentration of curry leaf ethanol extract antifungal Pityrosporum ovale and Candida albicans Table 4 demonstrates that even when using a 100% ethanol extract of curry leaves, there are still fungal colonies present. The number of colonies seen is 7 and 9, resulting in a reduction of 99.87% and 99.81%, respectively.…”

“…Traditional medicine is often regarded as a favorable alternative treatment for the community due to its minimal adverse reactions and its efficacy in delivering therapeutic results. 1 Fungi and bacteria are pathogens responsible for several ailments. Causes of infection resulting from bacterial or fungal pathogens fungi are a significant contributor to infectious diseases, particularly in tropical regions where the moist climate promotes the proliferation of fungal organisms.…”

Uji Aktivitas Antibakteri Ekstrak Daun Karenda (Carissa carandas Linn.) Terhadap Bakteri Propionibacterium acne dan Staphylococcus epidermidis

“…Jerawat adalah salah satu masalah yang dapat mengganggu keindahan kulit dan mengurangi rasa percaya diri seseorang (Amalyuri et al, 2022) Salah satu faktor yang dapat menyebabkan jerawat adalah bakteri Propionibacterium acne dan bakteri Staphylococcus epidermidis (Syahputra et al, 2022). Saat ini banyak sudah dikembangkan berbagai macam teknologi untuk mengatasi jerawat seperti penggunaan sediaan topical dengan bahan dasar kimiawi, penyinaran dengan sinar UV yang sudah pasti dapat menimbulkan efek samping yang tidak baik untuk kulit, salah satu efek sederhananya adalah mengiritasi kulit atau dapat mengganggu pertumbuhan sel kulit baru (Aliah et al, 2019).…”