Antibacterial properties of synthesized cyclic and linear cationic copolymers

Abstract

Cationic polymers are one of the main classes of materials investigated against bacteria through the membrane-lysis mechanism. The cationic-hydrophobic balance and distribution of cationic and hydrophobic moieties of these polymers...

Antibacterial Amphiphilic Copolymers of Dimethylamino Ethyl Methacrylate and Methyl Methacrylate to Control Biofilm Adhesion for Antifouling Applications

“…Xu et al investigated cationic polymers as the main classes of materials against bacteria through the membrane-lysis mechanism. They studied antibacterial effects of linear and cyclic monomers of cyclic poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMA) based copolymers with various components by the intra-chain click cyclization of α-alkyne-ω-azido via atom transfer radical polymerization [ 23 ]. In another study of amphiphilic polymers of thiazole ring 2-(2-(4-methylthiazol-5-yl)ethoxy)carbonyl)oxy)ethyl methacrylate monomer (MTZ) and non-hemotoxic poly(ethylene glycol) side chains (poly(ethylene glycol) methyl ether methacrylate (PEGMA) observed that longer hydrophobic chain, octyl were much more hemotoxic than their corresponding butylated copolymers [ 24 ].…”

Antibacterial and cytotoxic properties of star-shaped quaternary ammonium-functionalized polymers with different pendant groups

“…After incubation at 37 °C for 1 h, the bacterial cells were fixed with GA (2.5%) solution at room temperature for 30 min. The cells were washed with fresh PBS three times to remove the residual GA solution and dehydrated using a series of graded ethanol (30,50,70,90, and 100 vol.%) aqueous solutions. The dehydrated cells were dried at room temperature for 24 h, and their morphology was examined using field emission scanning electron microscopy (FE-SEM, S-4800, Hitachi).…”

“…Importantly, despite its similar M w , S-QAR had smaller D h than L-QAR, which could be attributed to its compact and globular molecular architecture resulting from multiple linear arms constrained on the core. [48][49][50] Particularly, D h of S-QAD was much smaller than that of L-QAD because its compact and constrained chain structure could effectively suppress its intermolecular entanglement and interactions, thereby reducing its aggregation. 51,52 Notably, S-QAC had D h ∼3.5 times larger than its diameter measured by TEM (Fig.…”

“…20,55,69,73 Furthermore, it has been demonstrated that the folded aliphatic cyclic chain structure can translocate deeper into the bacterial cell membrane via flipping and cause larger bilayer perturbation, inducing a higher bacterial killing effect compared with its aliphatic acyclic counterpart with a more extended conformation. 50,74 Hence, the higher antibacterial activity of QAC relative to QAH could be explained by its aliphatic cyclic pendant group, which could enhance membrane perturbation in bacterial cells. QAB was less antibacterial active than QAH mainly because of the higher hydrophilicity imparted by its benzyl pendant group.…”

Equilibrium Swelling of Biocompatible Thermo-Responsive Copolymer Gels

“…A particular interest to PDMAEMA-based gels is driven by their antibacterial activity [ 65 ] and applications as non-viral gene delivery systems [ 66 , 67 ]. Although PDMAEMA is a polymer with relatively high cytotoxicity [ 68 , 69 ], toxicity of PDMAEMA gels is strongly reduced by copolymerization of DMAEMA monomers with biocompatible monomers [ 70 , 71 , 72 , 73 ].…”