Antibacterial properties of TaN–(Ag,Cu) nanocomposite thin films

Hsieh, J.H.; Yeh, Tsung-Her; Li, Chuan; Chiu, Chiao-Fan; Huang, Chun-Chao

doi:10.1016/j.vacuum.2012.02.016

Cited by 40 publications

(11 citation statements)

References 13 publications

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“…Among the many applications intended for this coating in the field of biomedicine, the most promising could be its application in orthopedic prosthesis in order to further improve the interaction process between the device and bone tissue (21). However, to date industrial application of this kind of coatings is at an early stage (22).…”

Section: Introductionmentioning

confidence: 99%

Development of a Ta/TaN/TaNx(Ag)y/TaN nanocomposite coating system and bio-response study for biomedical applications

Echavarría

Rico

Ribelles

et al. 2017

Vacuum

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TaN(Ag) composited coatings are being investigated to improve biocompatibility of different biomedical devices due to the mechanical and chemical stability of TaN and bactericidal effect of silver nanoparticles. However, controlling the size, density, shape and especially the release of silver ions (Ag) into the surrounding medium becomes a challenge, since elevated levels of Ag could be cytotoxic. The aim of this work is to design and develop a new Ta/TaN/TaNx(Ag)y/TaN coating system, deposited by unbalanced DC magnetron sputtering technique, presenting an adequate balance between biocompatibility and bactericidal effect for potential applications in biomedical field. For this purpose, four different coating systems were deposited on 316L stainless steel and silicon (100) samples applying a bias voltage of-30,-60,-90 and-120V during the deposition of the top layer of TaN to vary its density. This manufacturing strategy allowed controlling the diffusion of silver nanoparticles to the coating surface and the release kinetics of silver ions in simulated body fluid (SBF). Biologic characterization has been performed with MC3T3-E1 pre-osteoblastic cells in terms of cell adhesion and long-term differentiation. Additionally, the adhesion and biofilm formation of the bacteria Streptococcus sanguinis strain in the deposited coating systems of Ta/TaN/TaNx(Ag)y/TaN were analyzed. The results indicated an improvement of cell adhesion and differentiation of the composited coating deposited with a bias of-30V compared to other coatings. Concordantly, this coating showed the lowest bacterial adhesion and biofilm formation, representing an attractive and suitable composited material for biomedical applications.

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Section: Introductionmentioning

confidence: 99%

Development of a Ta/TaN/TaNx(Ag)y/TaN nanocomposite coating system and bio-response study for biomedical applications

Echavarría

Rico

Ribelles

et al. 2017

Vacuum

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“…The appearance of an amorphous structure could be related to low deposition temperature and low sputtering power [50,51]. Previous studies have found that when the annealing temperature is about 800 • C, the Ta 2 O 5 film deposited by sputtering at room temperature starts to crystallize, while the crystallization temperature of Cu film is above 300 • C [52,53]. In addition, the diffraction peak of Ti appears in the XRD pattern, which may be due to the porous structure and small thickness of the coating, causing Ti to diffuse from the intermediate layer or substrate to the coating surface.…”

Section: Microstructure Characterizationmentioning

confidence: 99%

Microstructure, Wettability, Corrosion Resistance and Antibacterial Property of Cu-MTa2O5 Multilayer Composite Coatings with Different Cu Incorporation Contents

et al. 2019

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Bacterial infection and toxic metal ions releasing are the challenges in the clinical application of Ti6Al4V alloy implant materials. Copper is a kind of long-acting, broad-spectrum and safe antibacterial element, and Ta2O5 has good corrosion resistance, wear-resistance and biocompatibility, they are considered and chosen as a potential coating candidate for implant surface modification. In this paper, magnetron sputtering technology was used to prepare copper doped Ta2O5 multilayer composite coating Cu-Ta2O5/Ta2O5/Ta2O5-TiO2/TiO2/Ti (Cu-MTa2O5 for short) on Ti6Al4V alloy surface, for studying the effect of copper incorporation on the microstructure, wettability, anticorrosion and antibacterial activities of the composite coating. The results showed that Cu-MTa2O5 coating obviously improves the hydrophobicity, corrosion resistance and antibacterial property of Ti6Al4V alloy. In the coating, both copper and Ta2O5 exhibit an amorphous structure and copper mainly presents as an oxidation state (Cu2O and CuO). With the increase of the doping amount of copper, the grain size, roughness, and hydrophobicity of the modified surface of Ti6Al4V alloy are increased. Electrochemical experiment results demonstrated that the corrosion resistance of Cu-MTa2O5 coated Ti6Al4V alloy slightly decreased with the increase of copper concentration, but this coating still acts strong anticorrosion protection for Ti6Al4V alloy. Moreover, the Cu-MTa2O5 coating can kill more than 97% of Staphylococcus aureus in 24 h, and the antibacterial rate increases with the increase of copper content. Therefore, Cu-MTa2O5 composite coating is a good candidate for improving anticorrosion and antibacterial properties of Ti6Al4V alloy implant medical devices.

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“…For this purpose the films containing silver Ag [1][2][3][4][5][6][7][8][9][10][11][12][13][14] and copper Cu [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] were developed. It was found that both kinds of films efficiently kill bacteria if the content of Ag or Cu is higher than a minimum value, which usually is of about 10 at.% or greater.…”

Section: Introductionmentioning

confidence: 99%