Antibacterial secondary metabolites from an endophytic fungus, Fusarium solani JK10

Kyekyeku, James Oppong; Kusari, Souvik; Adosraku, Reimmel Kwame; Bullach, Anke; Golz, Christopher; Strohmann, Carsten; Spiteller, Michael

doi:10.1016/j.fitote.2017.04.007

Cited by 45 publications

(29 citation statements)

References 19 publications

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“…The study of HGT in eukaryotic genomes has become feasible, leading to the discovery of genes linked with HGT in different taxonomic groups of eukaryotes [36]. In recent times, HGT events observed in plant lineages [28,108] were found to be more common than expected. Moreover, the significance of HGT events in the evolution and adaptation of prokaryotes and eukaryotes was established; it has emerged as a key mechanism driving several biological processes, including insect resistance, C4 photosynthesis in grasses, parasite dynamics, etc.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, the significance of HGT events in the evolution and adaptation of prokaryotes and eukaryotes was established; it has emerged as a key mechanism driving several biological processes, including insect resistance, C4 photosynthesis in grasses, parasite dynamics, etc. [108]. In plant-associated microorganisms, the occurrence of HGT events was highlighted as an important evolutionary process for the acquisition of "novel traits" by either the host plant or the associated endophyte, which confers better adaptation and new functions to the organism and might have potential environmental and biotechnological applications.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, comparative genomics studies suggested that these fungi display similar genomic content to their associated organism, as well as symbiosis-specific genes [105,106]. The endophytic fungi can influence the physiology of the host plant by protecting against pathogenic fungi [104,107,108], promoting plant growth [97,109,110], and aiding nutrient and water uptake [111]. Moreover, studies have demonstrated the positive impacts of plant-endophyte associations in maintaining ecological balance and their potential biotechnological applications.…”

Section: Perspectives In Environment and Agriculturementioning

confidence: 99%

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Horizontal Gene Transfer and Endophytes: An Implication for the Acquisition of Novel Traits

Tiwari

Bae

2020

Plants

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Horizontal gene transfer (HGT), an important evolutionary mechanism observed in prokaryotes, is the transmission of genetic material across phylogenetically distant species. In recent years, the availability of complete genomes has facilitated the comprehensive analysis of HGT and highlighted its emerging role in the adaptation and evolution of eukaryotes. Endophytes represent an ecologically favored association, which highlights its beneficial attributes to the environment, in agriculture and in healthcare. The HGT phenomenon in endophytes, which features an important biological mechanism for their evolutionary adaptation within the host plant and simultaneously confers “novel traits” to the associated microbes, is not yet completely understood. With a focus on the emerging implications of HGT events in the evolution of biological species, the present review discusses the occurrence of HGT in endophytes and its socio-economic importance in the current perspective. To our knowledge, this review is the first report that provides a comprehensive insight into the impact of HGT in the adaptation and evolution of endophytes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Perspectives In Environment and Agriculturementioning

confidence: 99%

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Horizontal Gene Transfer and Endophytes: An Implication for the Acquisition of Novel Traits

Tiwari

Bae

2020

Plants

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“…Terrestrial endophytic Fusarium sp. Like Fusarium solani, F. oxysporum, F. acuminatum, F. tricinctum were reported to release structurally diversified anti-microbial secondary metabolites 28,[33][34][35][36] . Some investigators also claimed that marine-derived Fusarium sp.…”

Section: Discussionmentioning

confidence: 99%

Untitled

2020

IJPSR

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Endophyte is a rich source of bioactive metabolites for medicinal exploitation as an increasing number of novel compounds with bioactive potential are now being isolated from this source. This study was conducted to characterize and explore endophytic fungi from marine weeds available in Bangladesh. The whole weed was used for isolation of endophytic fungi in the water agar media and the isolated fungi were identified through macroscopic and microscopic observation. Small scale cultivation was performed on liquid Wickersham media. Cytotoxicity, antibacterial, antioxidant activities were evaluated following brine shrimp lethality bioassay, disc diffusion method and DPPH free radical scavenging assay, respectively. A total of five endophytic fungi were isolated, purified and characterized from four seaweeds; Hypnea musciformis (HM), Sargassum crassifolium (SC), Dictyota dichotoma (DD) and Caulerpa peltata (CP). They were coded as HMWE-1, HMWE-2, SCWE-1, DDWE-1 and CPWE-1. The fungal strains HMWE-1 and SCWE-1 were identified morphologically as Fusarium sp., HMWE-2 and DDWE-1 as Penicillium sp. and CPWE-1 as Aspergillus sp. DDWE-1 fungal strain showed significant antioxidant activity in comparison to the standard, ascorbic acid. The fungal extracts CPWE-1 (LC 50 value of 2.85 µg/mL) and DDWE-1 (LC 50 value of 6.38 µg/mL) showed significant cytotoxic activity. The extracts exhibited weak to good activity against a wide range of human pathogenic microorganisms during anti-microbial activity screening. Preliminary chemical screening by thin-layer chromatography (TLC) indicated the presence of a number of secondary metabolites. Thus, this study explored the potential entophytes from marine weeds of the Bay of Bengal as a producer of leads for drugs.

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“…Recently discovered antimicrobial compounds from Eutypella sp., L. theobromae and F. solani are eutypellenoids B, eut-Guainae sesquiterpene, libertellenone A, (? )-(R)-de-O-methyl-lasiodiplodin, fusariumester B, and 7-desmethyl fusarin C (Kyekyeku et al 2017;Wang et al 2018;Zhou et al 2017;Liu et al 2018;Umeokoli et al 2018;Yu et al 2018). The ability of these isolates to produce antimicrobial and other bioactive compounds shown in Table 3 may suggest that these fungi are potentially contributing to the chemical defense of the sponge host.…”

Section: Discussionmentioning

confidence: 99%

Sponge-associated fungi from a mangrove habitat in Indonesia: species composition, antimicrobial activity, enzyme screening and bioactive profiling

et al. 2019

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There is no report of diversity, biological properties and bioactive compounds of sponge-associated fungi from Indonesia's mangrove ecosystem to date. This study was designed to isolate sponge-associated fungi from a mangrove ecosystem in Mangkang, to screen the antimicrobial and extracellular enzyme properties of the isolates, characterize the biologically promising isolates using molecular approaches, and profile the secondary metabolites using phytochemical and thin-layer chromatography (TLC) analyses. An unidentified sponge that lived in association with mangrove roots was collected from Mangkang. Total of eight associated fungi were isolated from the sponge. Among all isolates, only two fungi SPMKF 1 and SPMKF 6 produced extracellular amylase, another two fungi SPMKF 4 and 5 showed antibacterial activity against MRSA, and only one fungus SPMKF 8 was able to produce extracellular amylase and show antimicrobial activity against ESBL E. coli, Salmonella enterica ser. Typhi strain MDR and C. albicans, while SPMKF 2, SPMKF 3 and SPMKF 9 did not show any biological properties. The result of genetic

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Antibacterial secondary metabolites from an endophytic fungus, Fusarium solani JK10

Cited by 45 publications

References 19 publications

Horizontal Gene Transfer and Endophytes: An Implication for the Acquisition of Novel Traits

Horizontal Gene Transfer and Endophytes: An Implication for the Acquisition of Novel Traits

Untitled

Sponge-associated fungi from a mangrove habitat in Indonesia: species composition, antimicrobial activity, enzyme screening and bioactive profiling

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