Antibacterial smart hydrogels: New hope for infectious wound management

Ahovan, Zahra Aliakbar; Esmaeili, Zahra; Eftekhari, Behnaz Sadat; Khosravimelal, Sadjad; Alehosseini, Morteza; Orive, Gorka; Dolatshahi‐Pirouz, Alireza; Chauhan, Narendra Pal Singh; Janmey, Paul A.; Hashemi, Ayoub; Kundu, Subhas C.; Gholipourmalekabadi, Mazaher

doi:10.1016/j.mtbio.2022.100499

Cited by 37 publications

(34 citation statements)

References 278 publications

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“…Multifunctional hydrogels have been prepared by modifying and loading nanomedicines for controlled drug release in a specific microenvironment to promote cell proliferation and kill bacteria. 11,12 Currently, researchers have developed many bio-nanomaterials with antibacterial and antioxidant properties, such as Zn, Cu, Ag and Ce complexes. [13][14][15][16][17][18][19] Therefore, it is promising to develop an intelligent hydrogel platform for synergistic antibacterial effect and oxidation resistance to improve wound healing.…”

Section: Introductionmentioning

confidence: 99%

A pH-responsive ZC-QPP hydrogel for synergistic antibacterial and antioxidant treatment to enhance wound healing

Zhang,

Wang,

Luo

et al. 2023

J. Mater. Chem. B

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Section: Introductionmentioning

confidence: 99%

A pH-responsive ZC-QPP hydrogel for synergistic antibacterial and antioxidant treatment to enhance wound healing

Zhang,

Wang,

Luo

et al. 2023

J. Mater. Chem. B

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“…The most important mechanism is its attachment (due to its cationic nature) to the cell wall of a negatively charged bacterium that disrupts the cell by reducing subsequent permeability to the membrane. By binding to DNA, it inhibits DNA replication and subsequent bacterial cell death 10,62 . Another mechanism proposed for the antibacterial properties of chitosan is its activity as a killing agent that produces toxins and inhibits microbial growth 38,63 …”

Section: Resultsmentioning

confidence: 99%

“…By binding to DNA, it inhibits DNA replication and subsequent bacterial cell death. 10,62 Another mechanism proposed for the antibacterial properties of chitosan is its activity as a killing agent that produces toxins and inhibits microbial growth. 38,63 The antibacterial activity of the hydrogels was evaluated against S. aureus and E. coli, the most important microorganisms in the wound and body environment.…”

Section: Antibacterial Propertiesmentioning

confidence: 99%

“…Chitosan is a biocompatible and biodegradable polymer with important biological features such as hemostatic and antibacterial properties. 10,11 Chitosan having structural similarity with glycosaminoglycans (GAGs) has been endorsed for cartilage tissue engineering applications. The modulatory effect of chitosan on different inflammatory cells has been reported in several studies.…”

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confidence: 99%

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An injectable chitosan/laponite hydrogel synthesized via hybrid cross‐linking system: A smart platform for cartilage regeneration

Ranjbardamghani

Eslahi

Jahanmardi

2023

Polymers for Advanced Techs

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Thermo-responsive polymeric hydrogels have received great attention in recent years. The current study aimed to fabricate and characterize injectable chitosan/ laponite (CS-L) hydrogels using a hybrid cross-linking method by genipin and β-glycerophosphate (BGP). Fourier transform infrared analysis confirmed the ionic and covalent interactions between the employed materials in the hydrogels. Scanning electron microscope images showed a decrease in the mean pore size from 129 to 83 μm after the incorporation of 1% laponite into the hydrogels. Energy dispersive X-ray analysis proved the uniform distribution of laponite in the hydrogels. Besides, the gelation time of the chitosan/laponite hydrogels declined in comparison to the chitosan hydrogel owing to the presence of abundant hydroxyl groups in the laponite structure. Rheological investigations revealed 600% improvement in the storage modulus after the incorporation of 1% laponite. The compression test results similarly showed that the elastic modulus and compressive strength of CS-L1% were significantly enhanced in comparison with pristine polymeric hydrogel. Non-toxicity and antibacterial properties of the hydrogels demonstrated 95% cell viability and 99% antibacterial activity, respectively. In conclusion, the obtained results confirmed that the introduced hybrid hydrogels are appropriate candidates for cartilage tissue engineering applications.cartilage tissue engineering, chitosan hydrogel, laponite, smart biomaterials | INTRODUCTIONPolymer hydrogels, with a cross-linked macromolecular structure, have been effectively utilized in tissue regeneration and drug delivery due to their hydrophilicity, biodegradation properties, releasing biochemical factors and simulating cellular milieus. [1][2][3] Injectable hydrogels are considered appropriate scaffolds for bone and cartilage tissue regeneration because of their ability to provide homogenous cell distribution before injection and in situ forming after injection, which results in the complete filling of irregular defects. These scaffolds provide a minimally invasive implantation procedure. 4 Smart nanohybrid hydrogels could endure sol-gel transition when exposed to external stimuli, such as temperature, pH, electrical or ionic strength alteration, leading to in-situ gelation of the injected sol inside the body. 5 Several chemical and physical cross-linking procedures such as the Michael reaction, "Click" reaction, Schiff base reaction, enzymatic and UV reaction have been employed in hydrogels. [6][7][8] Chemical reactions between a cross-linker and a polymer lead to a stable network, while physical interactions such as Van der Waals and hydrogen bonds result in a weaker network. In thermoresponsive hydrogels, the sol-gel transition occurs through temperature alteration. 9

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“…Compared with the strategy of antibiotics and antibacterial drugs to directly destroy the bacterial cell, inherent antibacterial hydrogels often show relatively poor antibacterial effects [ 29 ]. In recent years, researchers realized the high antibacterial activity of hydrogel dressings by external stimuli such as light, heat, sound, and electricity, including introducing photothermal agents into the hydrogel to increase the temperature of the wound, using photodynamic agents to release active oxygen to kill bacteria [ [30] , [31] , [32] ], destroying bacterial cell structures through ultrasonic, electrical stimulation, and other strategies [ 33 ]. Currently, the most significant factors for designing antibacterial hydrogel wound dressings are the selection of raw materials and the crosslinking methods.…”

Section: Introductionmentioning

confidence: 99%