Antibacterial surfaces developed from bio-inspired approaches

Glinel, Karine; Thébault, Pascal; Humblot, Vincent; Pradier, Claire‐Marie; Jouenne, Thierry

doi:10.1016/j.actbio.2012.01.011

Cited by 327 publications

(254 citation statements)

References 142 publications

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“…This can be achieved by impregnating the surface with an antimicrobial agent or using functionalized coatings that allow a localized antimicrobial delivery (Zilberman and Elsner 2008; Shukla et al 2010;Yala et al 2011). As reviewed by Glinel et al (2012), several AMP-based coatings have been tested successfully.…”

Section: Anti-biofilm Antimicrobial Peptide Strategiesmentioning

confidence: 99%

“…The rationale, at this point, is to obtain functionalized surfaces with proven anti-adhesive and anti-biofilm traits to later be tested as potential harmless biomaterials. Several promising studies have already been made, namely with polymer brushes, which have the advantage of being robust and can be generated in most biomedical materials (Gao et al 2011a). Glinel et al (2012 report on the existing findings in this field, but further studies are required in order to escalate findings onto a broader range of biomedical surfaces and devices.…”

Section: Prophylactic Strategiesmentioning

confidence: 99%

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New trends in peptide-based anti-biofilm strategies: a review of recent achievements and bioinformatic approaches

2012

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Antimicrobial peptides (AMPs) have a broad spectrum of activity and unspecific mechanisms of action. Therefore, they are seen as valid alternatives to overcome clinically relevant biofilms and reduce the chance of acquired resistance. This paper reviews AMPs and anti-biofilm AMP-based strategies and discusses ongoing and future work. Recent studies report successful AMP-based prophylactic and therapeutic strategies, several databases catalogue AMP information and analysis tools, and novel bioinformatics tools are supporting AMP discovery and design. However, most AMP studies are performed with planktonic cultures, and most studies on sessile cells test AMPs on growing rather than mature biofilms. Promising preliminary synergistic studies have to be consubstantiated and the study of functionalized coatings with AMPs must be further explored. Standardized operating protocols, to enforce the repeatability and reproducibility of AMP anti-biofilm tests, and automated means of screening and processing the ever-expanding literature are still missing.

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Section: Anti-biofilm Antimicrobial Peptide Strategiesmentioning

confidence: 99%

Section: Prophylactic Strategiesmentioning

confidence: 99%

New trends in peptide-based anti-biofilm strategies: a review of recent achievements and bioinformatic approaches

2012

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“…These peptides secreted by numerous living organisms against pathogens, have gained increased attention due to their broad spectrum of antimicrobial activity and their low cytotoxicity. [ 8,9 ] AMPs predominantly function by disruption of membrane integrity of pathogen or by damaging the membrane, for example, by forming pores. [ 10 ] They have antimicrobial activity against both Gram-positive and Gram-negative bacteria and they are also known to be antifungal and antiviral.…”

Section: Introductionmentioning

confidence: 99%

Harnessing the Multifunctionality in Nature: A Bioactive Agent Release System with Self‐Antimicrobial and Immunomodulatory Properties

Özçelik

Vrana

Gudima

et al. 2015

Adv Healthcare Materials

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Major problems with biomedical devices in particular implants located in nonsterile environments concern: (i) excessive immune response to the implant, (ii) development of bacterial biofi lms, and (iii) yeast and fungi infections. An original multifunctional coating that addresses all these issues concomitantly is developed. A new exponentially growing polyelectrolyte multilayer fi lm based on polyarginine (PAR) and hyaluronic acid (HA) is designed. The fi lms have a strong inhibitory effect on the production of infl ammatory cytokines released by human primary macrophage subpopulations. This could reduce potential chronic infl ammatory reaction following implantation. Next, it is shown that PAR, due to its positive charges, has an antimicrobial activity in fi lm format against Staphylococcus aureus for 24 h. In order to have a long-term antimicrobial activity, a precursor nanoscale silver coating is deposited on the surface before adding the PAR/HA fi lms. Moreover, the PAR/HA fi lms can be easily further functionalized by embedding antimicrobial peptides, like catestatin (CAT), a natural host defense peptide. This PAR/HA+CAT fi lm proves to be effective as an antimicrobial coating against yeast and fungi and its cytocompatibility is also assessed. Finally, this all-in-one system constitutes an original strategy to limit infl ammation and prevents bacteria, yeast, and fungi infections.

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“…[1,2] This has stimulated a search for polymers and other materials that resist the attachment of pathogens, or that exhibit antibacterial or bacteriostatic properties. [3][4][5][6][7][8][9] Materials discovery is now increasingly been carried out using high throughput synthesis and characterization methods so that novel, useful areas of materials property space can be identified. [10][11][12][13][14][15][16][17][18][19] While high throughput experimental techniques can dramatically accelerate new materials discovery, it is essential that complementary computational and informatics techniques are also are also be used.…”

Section: Introductionmentioning

confidence: 99%

Modelling and Prediction of Bacterial Attachment to Polymers

Epa

Hook

Chang

et al. 2013

Adv Funct Materials

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Infection by pathogenic bacteria on implanted and indwelling medical devices during surgery causes large morbidity and mortality worldwide. Attempts to ameliorate this important medical issue have included development of antimicrobial surfaces on materials, 'no touch' surgical procedures, and development of materials with inherent low pathogen attachment.The search for new materials is increasingly being carried out by high throughput methods.Efficient methods for extracting knowledge from these large data sets are essential. We used data from a large polymer microarray exposed to three clinical pathogens to derive robust and predictive machine-learning models of pathogen attachment. The models could predict pathogen attachment for the polymer library quantitatively. The models also successfully 22222222224222 predicted pathogen attachment for a second-generation library, and identified polymer surface chemistries that enhance or diminish pathogen attachment.

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Antibacterial surfaces developed from bio-inspired approaches

Cited by 327 publications

References 142 publications

New trends in peptide-based anti-biofilm strategies: a review of recent achievements and bioinformatic approaches

New trends in peptide-based anti-biofilm strategies: a review of recent achievements and bioinformatic approaches

Harnessing the Multifunctionality in Nature: A Bioactive Agent Release System with Self‐Antimicrobial and Immunomodulatory Properties

Modelling and Prediction of Bacterial Attachment to Polymers

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