Antibacterial Therapy of Septic Complications in Resistance of Pathogens to Carbapenems

Черненькая, В.

doi:10.23934/2223-9022-2017-6-1-34-40

Cited by 3 publications

(2 citation statements)

References 15 publications

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“…Также, тедизолид включен в Российские национальные рекомендации по лечению хирургических инфекций кожи и мягких тканей [7,9]. Помимо тедизолида применяются также даптомицин (липопептиды), цефтаролин (цефалоспорины), тигециклин (глицилциклины), телаванцин (гликопептиды) в качестве эпмирической терапии при наличии факторов риска MRSA-инфекции [8,21,45,[47][48][49][50][51].…”

Section: Introductionunclassified

Modern approach to antibacterial therapy in the practice of a surgeon

Морозов

Сергеев

Аскеров

et al. 2021

jour

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Relevance. Currently, all over the world, antibacterial therapy is widely used as a prophylaxis after surgical interventions. Currently, some data indicate the benefits of a short course, while others, in turn, indicate the benefits of a long course of antibacterial drugs as a prevention of postoperative complications. The problem of pan-resistance of bacterial strains in relation to almost all available groups of antibacterial drugs forces us to look for ways to overcome resistance, to look for new potential bases for the creation of antimicrobial drugs. New antibacterial drugs: odilorhabdins, tridecapeptins and malacidins, arilomycins and others will help to overcome the existing difficulties.The purpose of this study is to analyze the domestic and foreign literature for the period 2017–2021 in order to study the current approach to antibacterial therapy in surgical practice.Material and methods. In the course of this study, publications were selected according to the topic for the period from 2017 to 2021. The information was obtained from foreign and domestic sources: the Russian scientific electronic library, integrated with the Russian Science Citation Index (eLibrary.ru), Medline database (via Pubmed.gov), Scopus database, ScienceDirect database.Results. One of the significant difficulties in the treatment of wounds with antibacterial drugs of various localizations is the persistence of resistant strains of Staphylococcus aureus. In the studied studies, the high effectiveness of tedizolide phosphate in the treatment of this type of infection was noted. It is also possible to use other new drugs as epmiric therapy in the presence of risk factors for MRSA infection: daptomycin (lipopeptides), ceftaroline (cephalosporins), tigecycline (glycylcyclines), telavancin (glycopeptides)[41]. The use of biocides in the treatment of prostheses for hernioplasty as an antibacterial prophylaxis significantly reduces the adhesion of staphylococci and prevents postoperative complications. Suture material with antimicrobial activity, which would allow to fully reduce the risk of infections in the field of surgical intervention, is not yet available on the pharmaceutical market, but the increasing attention of scientists is attracted by chitosan, a derivative of the natural polymer chitin. The combined use of bacteriophages with low doses of antibiotics leads to better results in the treatment of surgical soft tissue infection. Bacteriophages are one of the ways to overcome antibiotic resistance.Conclusions. The modern approach to antibacterial therapy in surgical practice involves the correct and timely appointment of starting therapy, taking into account the sensitivity of microorganisms, the use of antibacterial preoperative prevention, determining the optimal duration of use and dose selection of an antibiotic, the use of sensitive bacteriophages together with them, overcoming antibiotic resistance due to the competent use of new antibacterial drugs based on peptides, a comprehensive approach to the treatment of surgical infection.

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Section: Introductionunclassified

Modern approach to antibacterial therapy in the practice of a surgeon

Морозов

Сергеев

Аскеров

et al. 2021

jour

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“…Карбапенемы продолжительное время считались универсальными высокоэффективными противомикробными препаратами. В современных условиях доля грамотрица тельных бактерий, резистентных к карбапенемам, постоянно увеличивается, это связано с распространением генов резистентности [3].…”

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Resistance of Clinical Isolates of Klebsiella Pneumoniae to Carbapenems Isolated from Patients with Secondary Bacterial Infection with COVID-19 for the Period 2019–2021

Буткевич¹,

Жаворонок²,

Гудкова³

et al. 2023

Клиническая Инфектология И Паразитология

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Введение. В период пандемии COVID-19 было опубликовано много результатов научных исследований, которые были посвящены изучению антибиотикорезистентных штаммов грамотрицательных бактерий. Однако эти данные постоянно изменяются на фоне антибиотикотерапии и генетических мутаций бактерий. В статье представлены данные анализа чувствительности/устойчивости K. pneumoniaeк карбапенемам с 2019 по 2021 год. Цель. Изучить динамику чувствительности/устойчивости к карбапенемам клинических изолятов K. pneumoniae, выделенных из биологического материала у пациентов со вторичной бактериальной инфекцией при COVID-19. Материалы и методы. Проанализирована чувствительность/устойчивость 503 клинических изолятов K. рneumoniae, выделенных от пациентов с коронавирусной инфекцией, направленных из различных регионов Республики Беларусь в РНПЦ пульмонологии и фтизиатрии в 2019–2021 гг. Результаты. Доля клинических изолятов K. pneumoniae, резистентных к карбапенемам, на фоне COVID-19 увеличилась в 2021 г. по сравнению с 2019 г. и составила: в 2019 г. для эртапенема – 46,4±3,35% (p=0,857101), имипенема – 35,8±3,19% (p=0,726331), меропенема – 39,6±3,28% (p=0,299603); в 2021 г. для эртапенема – 66,7±4,74% (p=0,000603), имипенема – 54,4±4,66% (p=0,001253) и меропенема – 54,5±4,49% (p=0,008182). Заключение. Среди клинических изолятов K. pneumoniae наблюдалось статистически значимое увеличение резистентности к карбапенемам в 2021 г. по сравнению с 2019 г. (эртапенем – в 1,4 раза, имипенем – в 1,5 раза, меропенем – в 1,4 раза). Introduction. During the COVID-19 pandemic, many research results have been published that have been devoted to the study of antibiotic-resistant strains of gram- negative bacteria. However, these data are constantly changing against the background of antibiotic therapy and genetic mutations of bacteria. The article presents data from the analysis of sensitivity/resistance of K. pneumoniae to carbapenems from 2019 to 2021. Purpose. To study the dynamics of sensitivity/resistance to carbapenems of clinical isolates of K. pneumoniae isolated from biological material in patients with secondary bacterial infection with COVID-19. Materials and methods. The sensitivity/resistance of 503 clinical isolates of K. pneumoniae isolated from patients with Сoronavirus infection referred from different regions of the Republic of Belarus to the Republican Scientific and Practical Center for Pulmonology and Phthisiology in 2019–2021 was analyzed. Results. The proportion of K. pneumoniaeclinical isolates resistant to carbapenems against the background of COVID-19 increased in 2021 compared to 2019 and amounted to 2019 ertapenem – 46.4±3.35% (p=0.857101), imipenem – 35.8±3.19% (p=0.726331) and meropenem – 39.6±3.28% (p=0.299603) and in 2021 ertapenem 66.7±4.74% (p=0.000603), imipenem 54.4±4.66% (p=0.001253) and meropenem 54.5±4.49% (p=0.008182). Conclusion. Among the clinical isolates of K. pneumoniae, a statistically significant increase in resistance to carbapenems was observed in 2021 compared to 2019 (ertapenem – 1.4 times, imipenem – 1.5 times and meropenem – 1.4 times).

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Features of the circulation of gram-negative carbapenem-resistant microorganisms in different departments of a multidisciplinary hospital

Voskanyan,

Yarovoy,

Tutelyan

et al. 2023

Sanitary Doctor

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Purpose — to study the features of the circulation of gram-negative microorganisms resistant to carbapenems from the «ESKAPE» group among patients from different departments of the hospital. The study showed that every 132nd patient hospitalized in a somatic multidisciplinary hospital in Moscow is a source of carbapenem-resistant gram-negative microorganisms from the «ESKAPE» pathogens (0.76 % [95 % CI: 0.7–0.8]). It was established that P. aeruginosa prevailed in the structure of «ESKAPE» pathogens that demonstrated resistance to carbapenems — 46.4 % [95 % CI: 43.1–49.5]; K. pneumoniae — 28.5 % [95 % CI: 25.7–31.4] and A. baumanii — 12.3 % [95 % CI: 10.3–14.5], and the maximum frequency of their detection was recorded from patients of the pulmonology department — 8.32 % [95 % CI: 7.71–8.97]. The structure and frequency of detection of sources of infection in departments is shown. Thus, strains of P. aeruginosa — 5.07 % [95 % CI: 4.49–5.58] and K. pneumoniae — 1.83 % [95 % CI: 1.54–2,15], with a specific gravity of 60.91 % and 21.98 %. In surgical patients, detection of E. coli prevailed (46.88 %) with a frequency of 0.16 % [95 % CI: 0.12–0.2], in intensive care units (70.73 %) K. pneumoniae strains were more common 0.27 % [95 % CI: 0.21–0.35], urological also K. pneumoniae 0.26 % [95 % CI: 0.2–0.34], therapeutic A. baumannii 0.11 % [95 % CI: 0.07–0.16], with a specific gravity of 50 %.

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Antibacterial Therapy of Septic Complications in Resistance of Pathogens to Carbapenems

Cited by 3 publications

References 15 publications

Modern approach to antibacterial therapy in the practice of a surgeon

Modern approach to antibacterial therapy in the practice of a surgeon

Resistance of Clinical Isolates of Klebsiella Pneumoniae to Carbapenems Isolated from Patients with Secondary Bacterial Infection with COVID-19 for the Period 2019–2021

Features of the circulation of gram-negative carbapenem-resistant microorganisms in different departments of a multidisciplinary hospital

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