Antibakteriell und abrasionsstabil: Entwicklung eines innovativen Silberverbundmaterials zur Anwendung als kieferorthopädisches Bracketmaterial

Abstract

Purpose Bacteria-induced white spot lesions are a common side effect of modern orthodontic treatment. Therefore, there is a need for novel orthodontic bracket materials with antibacterial properties that also resist long-term abrasion. The aim of this study was to investigate the abrasion-stable antibacterial properties of a newly developed, thoroughly silver-infiltrated material for orthodontic bracket application in an in situ experiment. Methods To generate the novel material, silver was vacuum-infiltrated into a sintered porous tungsten matrix. A tooth brushing simulation machine was used to perform abrasion equal to 2 years of tooth brushing. The material was characterized by energy dispersive X‑ray (EDX) analysis and roughness measurement. To test for antibacterial properties in situ, individual occlusal splints equipped with specimens were worn intraorally by 12 periodontal healthy patients for 48 h. After fluorescence staining, the quantitative biofilm volume and live/dead distribution of the initial biofilm formation were analyzed by confocal laser scanning microscopy (CLSM). Results Silver was infiltrated homogeneously throughout the tungsten matrix. Toothbrush abrasion only slightly reduced the material’s thickness similar to conventional stainless steel bracket material and did not alter surface roughness. The new silver-modified material showed significantly reduced biofilm accumulation in situ. The effect was maintained even after abrasion. Conclusion A promising, novel silver-infiltrated abrasion-stable material for use as orthodontic brackets, which also exhibit strong antibacterial properties on in situ grown oral biofilms, was developed. The strong antibacterial properties were maintained even after surface abrasion simulated with long-term toothbrushing.

Effectiveness of strontium/silver-based titanium surface coatings in improving antibacterial and osteogenic implant characteristics: a systematic review of in-vitro studies

“…A first point that need to be considered is the expected mechanical stability as all applied functionalizations were superficial coatings (Table 2). Titanium implants, both for dental and orthopedic applications, experience harsh shear stresses during implantation, which often only full material modifications Frontiers in Bioengineering and Biotechnology frontiersin.org can withstand (Denis et al, 2024). Thus, the developed functionalizations need to be tested for their stability and if not fulfilling these requirements alternative application areas with less shear stress, like dental abutments should be considered.…”

Application of an Antibacterial Coating Layer via Amine-Terminated Hyperbranched Zirconium–Polysiloxane for Stainless Steel Orthodontic Brackets

“…increases significantly during orthodontic treatment, and white spot lesions on the tooth surface can occur in 2%-96% of patients [6,7], progressing to dental caries, gingivitis [8], and periodontitis [9,10]. Developing an antibacterial and biocompatible coating material has crucial therapeutic implications for avoiding problems during orthodontic procedures [11][12][13].…”

Effect of titanium implants along with silver ions and tetracycline on type I interferon-beta expression during implant-related infections in co-culture and mouse model

“…Silver ions generate hydroxyl radicals which interfere with bacterial metabolism resulting in the better elimination of the bacteria ( Yamanaka et al, 2005 ; Park et al, 2009 ). The application of silver on dental implants showed significant antibacterial activity against multispecies biofilms ( Noronha et al, 2017 ; Denis et al, 2022 ). Host immune cells recognize silver as foreign molecules, and exposure of the silver to these cells could either stimulate or suppress the expression of inflammatory cytokines ( Ninan et al, 2020 ).…”