Antibiotic Against Gram‐Negative Bacteria

Faiyaz, Maryam; Gupta, Shikha; Gupta, Divya

doi:10.1002/9781119460053.ch4

Cited by 1 publication

(1 citation statement)

References 102 publications

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“…Furthermore, it has been reported that cefprozil exhibits antibacterial activity against Haemophilus influenzae , Moraxella catarrhalis , Neisseria gonorrhoeae , many Enterobacteriaceae, and certain anaerobic organisms [1]. Broad antibacterial range and activities of cefprozil have been reported in the past [2,3,4]. The reason why cefprozil can exhibit such broad antibacterial range and activity against resistant bacteria is due to physicochemical properties of cefprozil, which is stable to hydrolysis by many beta-lactamase enzymes [1].…”

Section: Introductionmentioning

confidence: 99%

Population Pharmacokinetics of Cis-, Trans-, and Total Cefprozil in Healthy Male Koreans

et al. 2019

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Cefprozil, one of cephalosporin antibiotics, has been used extensively in clinics. However, pharmacokinetic (PK) information on cefprozil is still very limited. There have been no reports of population pharmacokinetics (PPKs). A PPK model for cefprozil will be a great advantage for clinical use. Thus, the aim of this study was to develop a PPK model for cefprozil for healthy male Koreans. Clinical PK and demographic data of healthy Korean males receiving cefprozil at a dose of 1000 mg were analyzed using Phoenix® NLME™. A one-compartment model with first-order absorption with lag-time was constructed as a base model. The model was extended to include covariates that influenced between-subject variability. Creatinine clearance significantly influenced systemic clearance of cefprozil. The final PPK model for cis-, trans-, and total cefprozil was established and validated. PPK parameter values of cis- and total cefprozil were similar to each other, but different from those of trans-isomer. Herein, we describe the establishment of accurate PPK models of cis-, trans-, and total cefprozil for healthy male Koreans for the first time. It may be useful as a dosing algorithm for the general population. These results might also contribute to the development of stereoisomeric cefprozil.

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