Antibiotic Exposure and the Risk for Depression, Anxiety, or Psychosis

Lurie, Ido; Yang, Yu‐Xiao; Haynes, Kevin; Mamtani, Ronac; Boursi, Ben

doi:10.4088/jcp.15m09961

Cited by 197 publications

(118 citation statements)

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“…The urinary tract was the most common site of infection in women while the respiratory tract and mucosal surfaces were the most common sites in men. An association between antibiotic exposure and mood disorder has also been found in population based studies performed in the United Kingdom (Lurie, Yang, Haynes, Mamtani, & Boursi, 2015) and Denmark (Kohler et al, 2016). …”

Section: Resultsmentioning

confidence: 66%

The microbiome, immunity, and schizophrenia and bipolar disorder

Dickerson

Severance

Yolken

2017

Brain, Behavior, and Immunity

218

128

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Schizophrenia and bipolar disorder are serious neuropsychiatric disorders of uncertain etiology. Recent studies indicate that immune activation may contribute to the etiopathogenesis of these disorders. Numerous studies in animal models indicate that the mucosal microbiome may influence cognition and behavior by altering the functioning of the immune system. It is thus likely that the microbiome plays a role in human psychiatric disorders. The study of immune alterations and the microbiome in schizophrenia and bipolar disorder is in its infancy. Two recent investigations of the oro-pharyngeal microbiota in schizophrenia found differences between cases and controls. Other studies have found increased gastrointestinal inflammation in schizophrenia and bipolar disorder based on measures of microbial translocation. Several studies have also found an association between the receipt of antibiotics and an increased incidence of psychiatric disorders, perhaps due to alterations in the microbiome. Studies to characterize the intestinal microbiome of individuals with these disorders are in progress. The ultimate test of the role of the microbiome and immune-mediated pathology in schizophrenia and bipolar disorder will come from clinical trials of therapeutic agents which alter gut microbiota or gastrointestinal inflammation. The successful development of such modalities would represent a novel strategy to prevent and treat serious psychiatric disorders.

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Section: Resultsmentioning

confidence: 66%

The microbiome, immunity, and schizophrenia and bipolar disorder

Dickerson

Severance

Yolken

2017

Brain, Behavior, and Immunity

218

128

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“…Gut microbiota can influence neural development, cognition, and behavior, and modulate nervous system function [62,63], with researches showing the interrelationship between changes in behavior such as depressionlike behaviors and modifications of the microbiota, such as the psychiatric side-effects of antibiotics containing anxiety, depression, psychosis, and delirium, which appears to represent direct mediators of psychopathology [64][65][66]. Meanwhile, the association of dysbiosis with disease, especially functional bowel disorders has acquired more attention [67].…”

Section: Relationship Between Stress and Gut Disorders Via Microbiomementioning

confidence: 99%

The Local Defender and Functional Mediator: Gut Microbiome

Yang¹,

Duan²

2018

Digestion

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Background: The gut microbiome has been developing and making adaption all the time, which is consistent with their host from the initial colonization at birth or earlier. Emerging evidence is showing that dysbiosis is involved in various diseases associated with immune, metabolism, infection, nervous system, social behaviors, and psychopathology, etc., maybe via modulating gut barrier, microbiome-gut-brain axis, or some metabolites like short-chain fatty acids (SCFAs). Summary: In the review, we will conclude the recent researches related to the influence of microbiome on local structure, function, regulation, metabolism of gut, and systematic modulation to the host, as well as some affective factors such as diet or antibiotics. Key Messages: It is a reasonable hypothesis that the balance of bioactive factors or cells and the opposites such as the regulatory T/helper T17 balance and interleukin (IL)-10/IL-17 balance plays a vital role in homeostasis of immunity system. Meanwhile, the link between gut microbiome and immune system via microbiota-derived metabolite SCFAs involved in multi-function of the host locally and systematically has been revealed. We hope to contribute to the microbiome-targeted treatment and prevention of some diseases.

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“…In experimental research antibiotic exposure during pregnancy disturbs microbiota and causes behavioral deficits in offspring [243], while human studies have linked antibiotic use to depression and anxiety [244]. Pathways of microbial influences on brain development, stress physiology, mood, cognition and behavior include, but are not limited to: immune-mediated pathways, enhancement of nutrient bioavailability and neurotransmitter precursors, support of the gastrointestinal barrier, redox homeostasis, and even direct gut microbe-to-brain communication via the vagus nerve [245].…”

Section: Humans Microbes Environment As An Ecological Unitmentioning

confidence: 99%

Transforming Life: A Broad View of the Developmental Origins of Health and Disease Concept from an Ecological Justice Perspective

Prescott

Logan²

2016

IJERPH

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The influential scientist Rene J. Dubos (1901–1982) conducted groundbreaking studies concerning early-life environmental exposures (e.g., diet, social interactions, commensal microbiota, housing conditions) and adult disease. However, Dubos looked beyond the scientific focus on disease, arguing that “mere survival is not enough”. He defined mental health as fulfilling human potential, and expressed concerns about urbanization occurring in tandem with disappearing access to natural environments (and elements found within them); thus modernity could interfere with health via “missing exposures”. With the advantage of emerging research involving green space, the microbiome, biodiversity and positive psychology, we discuss ecological justice in the dysbiosphere and the forces—financial inequity, voids in public policy, marketing and otherwise—that interfere with the fundamental rights of children to thrive in a healthy urban ecosystem and learn respect for the natural environment. We emphasize health within the developmental origins of health and disease (DOHaD) rubric and suggest that greater focus on positive exposures might uncover mechanisms of resiliency that contribute to maximizing human potential. We will entrain our perspective to socioeconomic disadvantage in developed nations and what we have described as “grey space”; this is a mental as much as a physical environment, a space that serves to insidiously reinforce unhealthy behavior, compromise positive psychological outlook and, ultimately, trans-generational health. It is a dwelling place that cannot be fixed with encephalobiotics or the drug-class known as psychobiotics.

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Antibiotic Exposure and the Risk for Depression, Anxiety, or Psychosis

Abstract: Recurrent antibiotic exposure is associated with increased risk for depression and anxiety but not for psychosis.

Cited by 197 publications

References 0 publications

The microbiome, immunity, and schizophrenia and bipolar disorder

The microbiome, immunity, and schizophrenia and bipolar disorder

The Local Defender and Functional Mediator: Gut Microbiome

Transforming Life: A Broad View of the Developmental Origins of Health and Disease Concept from an Ecological Justice Perspective

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