Antibiotic irrigation-perfusion treatment for chronic osteomyelitis

Boda, A

doi:10.1007/bf00379167

Cited by 12 publications

(3 citation statements)

References 16 publications

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“…Patients in the FVFG group previously had undergone several operations, such as serial debridements, flap surgeries, antibiotic-impregnated polymethylmethacrylate (PMMA) bead chains, 22 irrigation and suction drainage, 23 and tibio-fibular synostosis 4,5 at an average of 3.8 times (range: 2 to 5 times). Patients in the CD group also had previously undergone several operations at an average of 4.3 times (range: 2 to 6 times).…”

Section: Clinical Materialsmentioning

confidence: 99%

Free Vascularized Fibular Graft vs. Ilizarov Method for Post-Traumatic Tibial Bone Defect

Yokoyama

Itoman²,

Nakamura³

et al. 2001

J reconstr Microsurg

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From 1991 to 1996, four free vascularized fibular grafts (FVFG) and four callus distraction (CD) techniques were performed for post-traumatic tibial defects at the authors' institute. They attempted to discern any differences of results between FVFGs and CDs for post-traumatic tibial defects. The mean defect length of the FVFG and CD groups were 7.3 cm and 4.6 cm, respectively (p < 0.05). They selected as contributing factors: external fixation time, complication rate, hospital charge, union rate, and functional score (Puno's criteria), in order to compare the treatment of FVFG with that of CD. The external fixation times of the FVFG and CD groups were 176 days and 261 days, respectively. One septic non-union after refracture of the grafted fibula occurred in the FVFG group. Two non-unions (50 percent) at the docking site occurred in the CD group. The mean total costs of the FVFG and CD groups were 7,398,536 yen (US $68,505) and 11,798,153 yen(US $109,242), respectively. The union rates of both groups were 75 percent and 100 percent, respectively. The mean functional scores of both groups were 69.5 and 88.8 points, respectively. The functional results of the FVFG group were as follows: one patient showed good results; one, fair; and two, poor. The functional results of the CD group were as follows: two patients showed excellent results; one, good; and one, fair. Both the costs and the functional outcomes between the two groups did not significantly differ. No clear differences between the two treatment groups could be determined. However, many more cases are needed to establish statistically significant differences between both methods.

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Section: Clinical Materialsmentioning

confidence: 99%

Free Vascularized Fibular Graft vs. Ilizarov Method for Post-Traumatic Tibial Bone Defect

Yokoyama

Itoman²,

Nakamura³

et al. 2001

J reconstr Microsurg

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“…Antibiotic administration without surgery may eradicate infection only for some exceptions: childhood osteomyelitis, spondylodiscitis, tuberculous osteomyelitis, and in selected cases, diabetic toe osteomyelitis. On the other hand, lack of systemic antibiotics [29] yields higher failure rates, highlighting an independent benefit of concomitant antibiotic therapy.…”

Section: Treatmentmentioning

confidence: 99%

Chronic Osteomyelitis

Uçkay

Jugun

Gamulin

et al. 2012

Curr Infect Dis Rep

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Chronic osteomyelitis is a multifaceted bacterial infection with common features. It absolutely requires surgery for remission. The duration and form of concomitant administration of antibiotic agents for adult patients is still based on expert opinion. The traditional recommendation of 6-12 weeks of antibiotic therapy, where, for at least the first 2-6 weeks, antibiotics should be administered intravenously, is more and more challenged in favor of an oral antibiotic treatment with selected agents from the start. There is no evidence that the total duration of antibiotic therapy for more than 4-6 weeks improves outcome, when compared with shorter regimens. Hopefully, the future will show randomized trials in the adult population, allowing optimal timing of surgical and medical therapy and sparing of unnecessary prescription, with concomitant development of antibiotic resistance. External advice from an expert team with combined surgeons and infectious disease physicians may help to reduce antibiotic consumption in a costeffective way.

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“…In practice, briefer intravenous courses may be followed by long‐term oral administration for most patients. Delivery of antibiotics by the irrigation‐perfusion technique has not been shown to be as efficacious 7 . The use of hyperbaric oxygen as an adjunct to antimicrobial therapy has been advocated as a means of improving local vascularity 8 but has not been evaluated in a controlled clinical setting.…”

Section: Commentsmentioning

confidence: 99%

Vapor‐Permeable Membrane Therapy for Ulcers of Osteomyelitis

Alper

Urbaniak

1984

The Journal of Dermatologic Surgery and Oncology

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Two patients with chronic ulcerations secondary to arterial insufficiency of the distal extremities were found to have concomitant osteomyelitis immediately beneath the ulcers. An adjunctive would care regimen is described in which local excision or debridement of the involved bone with subsequent systemic antibiotic therapy was the initial treatment. The resultant cutaneous defect was then covered with a vapor-permeable membrane and allowed to close by secondary intention. Rapid and complete healing occurred in both cases in spite of the compromised arterial supply to both areas. This technique is a useful adjunct to the treatment of ulcerations associated with chronic osteomyelitis.

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Antibiotic irrigation-perfusion treatment for chronic osteomyelitis

Cited by 12 publications

References 16 publications

Free Vascularized Fibular Graft vs. Ilizarov Method for Post-Traumatic Tibial Bone Defect

Free Vascularized Fibular Graft vs. Ilizarov Method for Post-Traumatic Tibial Bone Defect

Chronic Osteomyelitis

Vapor‐Permeable Membrane Therapy for Ulcers of Osteomyelitis

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