The Orchestra program has provided a unique opportunity to assess and improve prevention and management of co-morbidities in HIV patients.

This paper reports 125 antibiotic irrigation-perfusion treatments of chronic osteomyelitic patients. The localisation of the osteomyelitic process, the duration of the disease, the duration of the treatment, the age distributions of the patients, and the results of the treatment are noted. The study revealed that only one third of the patients healed after the irrigation-perfusion treatment. This rate falls short of the results reported in the literature. The possible causes are discussed and emphasis is given to the technical problems. On the basis of this survey the author is of the opinion that this method is to be employed only in exceptional cases of bone infections. The indication and contraindications are precisely defined.

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On the basis of bacteriology results of osteomyelitic patients of the recent 10 year period the authors examined the changes of antibiotic sensitivity/resistancy relations of strains of coagulase positive Staphylococcus aureus haemolyticus. Examination of 385 strains of Staphylococci showed that Staphylococci originating from osteomyelitic patients are more sensitive, respectively in a lesser degree resistant to antibiotics than those of miscellaneous origin. Concerning 8, in everyday practice most commonly used antibiotics, by means of regression trend line analysis, it has been stated that in the period of 1966-1975 years Staphylococci originating from osteomyelitic patients show a decreasing resistancy to antibiotics examined. The authors are of the opinion that in osteomyelitic patients the no satisfactory results and the high number of recurrent inflammations are not attributable to resistant strains of Staphylococci, but are due to many other biologic factors.