Antibiotic-loaded, silver core-embedded mesoporous silica nanovehicles as a synergistic antibacterial agent for the treatment of drug-resistant infections

Wang, Yao; Ding, Xuan; Chen, Yuan; Guo, Mingquan; Zhang, Yan; Guo, Xin; Gu, Hongchen

doi:10.1016/j.biomaterials.2016.06.004

Cited by 169 publications

(116 citation statements)

References 48 publications

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“…[22][23][24][25][26][27] Conventionally, silver NPs are immobilized onto or embedded into MSNs to avoid the aggregation of silver NPs. 28,29 Thus, these nanocarriers slowly release silver ions, leading to enhanced efficacy against bacteria. 30,31 In addition, MSNs with entrapped CHX can exhibit sustainable CHX release behavior and inhibit bacterial growth while maintaining their surface integrity.…”

mentioning

confidence: 99%

Synergistic bactericidal activity of chlorhexidine-loaded, silver-decorated mesoporous silica nanoparticles

Lu¹,

Wang²,

Chang³

et al. 2017

IJN

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Combination of chlorhexidine (CHX) and silver ions could engender synergistic bactericidal effect and improve the bactericidal efficacy. It is highly desired to develop an efficient carrier for the antiseptics codelivery targeting infection foci with acidic microenvironment. In this work, monodisperse mesoporous silica nanoparticle (MSN) nanospheres were successfully developed as an ideal carrier for CHX and nanosilver codelivery through a facile and environmentally friendly method. The CHX-loaded, silver-decorated mesoporous silica nanoparticles (Ag-MSNs@CHX) exhibited a pH-responsive release manner of CHX and silver ions simultaneously, leading to synergistically antibacterial effect against both gram-positive Staphylococcus aureus and gram-negative Escherichia coli . Moreover, the effective antibacterial concentration of Ag-MSNs@CHX showed less cytotoxicity on normal cells. Given their synergistically bactericidal ability and good biocompatibility, these nanoantiseptics might have effective and broad clinical applications for bacterial infections.

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mentioning

confidence: 99%

Synergistic bactericidal activity of chlorhexidine-loaded, silver-decorated mesoporous silica nanoparticles

Lu¹,

Wang²,

Chang³

et al. 2017

IJN

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“…Therefore, it is highly desirable to introduce antimicrobial agents into implant surfaces to provide antibacterial activities and prevent peri-implant infections [13][14][15][16][17]. In comparison with organic antibiotics, inorganic antibacterial metal elements (e.g., silver (Ag) [18][19][20][21][22], copper (Cu) [23][24][25][26] and zinc (Zn) [27][28][29]) have attracted great attention due to their perfect stabilities, superior broad-spectrum antibacterial properties, relatively low toxicity to human cells and low risk of producing resistant strains [30,31].…”

Section: Introductionmentioning

confidence: 99%

Review of Antibacterial Activity of Titanium-Based Implants’ Surfaces Fabricated by Micro-Arc Oxidation

Zhang

Wang

et al. 2017

Coatings

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Ti and its alloys are the most commonly-used materials for biomedical applications. However, bacterial infection after implant placement is still one of the significant rising complications. Therefore, the application of the antimicrobial agents into implant surfaces to prevent implant-associated infection has attracted much attention. Scientific papers have shown that inorganic antibacterial metal elements (e.g., Ag, Cu, Zn) can be introduced into implant surfaces with the addition of metal nanoparticles or metallic compounds into an electrolyte via micro-arc oxidation (MAO) technology. In this review, the effects of the composition and concentration of electrolyte and process parameters (e.g., voltage, current density, oxidation time) on the morphological characteristics (e.g., surface morphology, bonding strength), antibacterial ability and biocompatibility of MAO antimicrobial coatings are discussed in detail. Anti-infection and osseointegration can be simultaneously accomplished with the selection of the proper antibacterial elements and operating parameters. Besides, MAO assisted by magnetron sputtering (MS) to endow Ti-based implant materials with superior antibacterial ability and biocompatibility is also discussed. Finally, the development trend of MAO technology in the future is forecasted.

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“…Moreover, MSNs hold great potential in order to integrate therapeutic and diagnostic functions (such as imaging contrasting agents) within a single system to create unique structures . In this context, various nanocomposites (e.g., MSN–magnetic NPs, MSN–quantum dots, MSN–silver NPs, MSN–gold nanoparticles, and MSN–upconversion NPs) designed/fabricated for different applications that can be also used in the treatment of bacterial infection. It should be emphasized that the core of the MS can serve not only as imaging tool but also acts as therapeutic function.…”

Section: Mesoporous Silica Nanostructuresmentioning

confidence: 99%

Mesoporous Silica‐Based Materials with Bactericidal Properties

Bernardos

Piacenza

Sancenón

et al. 2019

Small

146

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Bacterial infections are the main cause of chronic infections and even mortality. In fact, due to extensive use of antibiotics and, then, emergence of antibiotic resistance, treatment of such infections by conventional antibiotics has become a major concern worldwide. One of the promising strategies to treat infection diseases is the use of nanomaterials. Among them, mesoporous silica materials (MSMs) have attracted burgeoning attention due to high surface area, tunable pore/particle size, and easy surface functionalization. This review discusses how one can exploit capacities of MSMs to design and fabricate multifunctional/controllable drug delivery systems (DDSs) to combat bacterial infections. At first, the emergency of bacterial and biofilm resistance toward conventional antimicrobials is described and then how nanoparticles exert their toxic effects upon pathogenic cells is discussed. Next, the main aspects of MSMs (e.g., physicochemical properties, multifunctionality, and biosafety) which one should consider in the design of MSM‐based DDSs against bacterial infections are introduced. Finally, a comprehensive analysis of all the papers published dealing with the use of MSMs for delivery of antibacterial chemicals (antimicrobial agents functionalized/adsorbed on mesoporous silica (MS), MS‐loaded with antimicrobial agents, gated MS‐loaded with antimicrobial agents, MS with metal‐based nanoparticles, and MS‐loaded with metal ions) is provided.

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Antibiotic-loaded, silver core-embedded mesoporous silica nanovehicles as a synergistic antibacterial agent for the treatment of drug-resistant infections

Cited by 169 publications

References 48 publications

Synergistic bactericidal activity of chlorhexidine-loaded, silver-decorated mesoporous silica nanoparticles

Synergistic bactericidal activity of chlorhexidine-loaded, silver-decorated mesoporous silica nanoparticles

Review of Antibacterial Activity of Titanium-Based Implants’ Surfaces Fabricated by Micro-Arc Oxidation

Mesoporous Silica‐Based Materials with Bactericidal Properties

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