Antibiotic peptide-modified nanostructured titanium surface for enhancing bactericidal property

Zhu, Chen; Zhang, Weiwei; Fang, Shiyuan; Kong, Rong; Zou, Gang; Bao, Nirong; Zhao, Jianning; Shang, Xifu

doi:10.1007/s10853-017-1669-2

Cited by 6 publications

(4 citation statements)

References 74 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Specifically, they can inhibit the synthesis of cell walls and proteins, damage DNA replication, and interfere with intermediary metabolism 56. However, the application of antibiotics may trigger allergic reactions, and produce drug-resistant bacteria, making it more difficult to prevent infection 57. Compared with antibiotics, antimicrobial peptides exhibit better immunocompatibility, less toxicity, and a lower risk of developing drug resistance.…”

Section: Potential Antibacterial Applications For Orthopedic Implantsmentioning

confidence: 99%

“…Compared with antibiotics, antimicrobial peptides exhibit better immunocompatibility, less toxicity, and a lower risk of developing drug resistance. In addition, they can effectively kill intracellular bacteria and reduce the risk of chronic infection 57. Li et al58 combined GL13K with TNTs and found that the composite TNTs exerted a strong antibacterial effect while exhibiting better biocompatibility than metronidazole-loaded TNTs.…”

Section: Potential Antibacterial Applications For Orthopedic Implantsmentioning

confidence: 99%

See 1 more Smart Citation

<p>Enhanced antibacterial properties of orthopedic implants by titanium nanotube surface modification: a review of current techniques</p>

Yang

et al. 2019

IJN

View full text Add to dashboard Cite

Prosthesis-associated infections are one of the main causes of implant failure; thus it is important to enhance the long-term antibacterial ability of orthopedic implants. Titanium dioxide nanotubes (TNTs) are biomaterials with good physicochemical properties and biocompatibility. Owing to their inherent antibacterial and drug-loading ability, the antibacterial application of TNTs has received increasing attention. In this review, the process of TNT anodizing fabrication is summarized. Also, the mechanism and the influencing factors of the antibacterial property of bare TNTs are explored. Furthermore, different antibacterial strategies for carrying drugs, as well as modifications to prolong the antibacterial effect and reduce drug-related toxicity are discussed. In addition, antibacterial systems based on TNTs that can automatically respond to infection are introduced. Finally, the currently faced problems are reviewed and potential solutions are proposed. This review provides new insight on TNT fabrication and summarizes the most advanced antibacterial strategies involving TNTs for the enhancement of long-term antibacterial ability and reduction of toxicity.

show abstract

Section: Potential Antibacterial Applications For Orthopedic Implantsmentioning

confidence: 99%

Section: Potential Antibacterial Applications For Orthopedic Implantsmentioning

confidence: 99%

<p>Enhanced antibacterial properties of orthopedic implants by titanium nanotube surface modification: a review of current techniques</p>

Yang

et al. 2019

IJN

View full text Add to dashboard Cite

show abstract

“…To target AMPs to specific sites and to protect them from untimely degradation, increasing attention is being paid to combining them with different nanocarriers , including negatively charged polyion complex micelles, silica nanoparticles, oleic acid self-assemblies, microgels, , and PEGylated lipid micelles . Furthermore, AMPs have been applied to microstructured surfaces in order to physically anchor them on a surface or to increase their surface density . Immobilization was achieved on different surfaces such as metal-, , nanoparticle-, polymer-, , microgel-, , or polymer/lipid-based surfaces by various physical or chemical methods .…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, AMPs have been applied to microstructured surfaces in order to physically anchor them on a surface or to increase their surface density . Immobilization was achieved on different surfaces such as metal-, , nanoparticle-, polymer-, , microgel-, , or polymer/lipid-based surfaces by various physical or chemical methods . For example, cecropin-melittin was immobilized at high density on gold nanoparticle-coated surfaces through an increase in surface area from the nanoparticles .…”

Section: Introductionmentioning

confidence: 99%

Decorating Nanostructured Surfaces with Antimicrobial Peptides to Efficiently Fight Bacteria

Rigo

Hürlimann

Marot

et al. 2020

ACS Appl. Bio Mater.

View full text Add to dashboard Cite

With conventional antibiotic therapies being increasingly ineffective, bacterial infections with subsequent biofilm formation represent a global threat to human health. Here, an active and a passive strategy based on polymeric micelles were combined to fight bacterial growth. The passive strategy involved covalent immobilization of polymeric micelles through Michael addition between exposed maleimide and thiol functionalized surfaces. Compared to the bare surface, micelle-decorated surfaces showed reduced adherence and survival of bacteria. To extend this passive defense against bacteria with an active strategy, the immobilized micelles were equipped with the antimicrobial peptide KYE28 (KYEITTIHNLFRKLTHRLFRRNFGYTLR). The peptide interacted nonspecifically with the immobilized micelles where it retained its antimicrobial property. The successful surface decoration with KYE28 was demonstrated by a combination of X-ray photoelectron spectroscopy and quartz crystal microbalance with dissipation monitoring. The initial antimicrobial activity of the nanostructured surfaces against Escherichia coli was found to be increased by the presence of KYE28. The combination of the active and passive strategy represents a straightforward modular approach that can easily be adapted, for example, by exchanging the antimicrobial peptide to optimize potency against challenging bacterial strains, and/or to simultaneously achieve antimicrobial and anti-infection properties.

show abstract

Considerations for Designing Next-Generation Composite Dental Materials

Pfeifer

Kreth

Koley

et al. 2021

Oral Biofilms and Modern Dental Materials

View full text Add to dashboard Cite

Antibiotic peptide-modified nanostructured titanium surface for enhancing bactericidal property

Cited by 6 publications

References 74 publications

<p>Enhanced antibacterial properties of orthopedic implants by titanium nanotube surface modification: a review of current techniques</p>

<p>Enhanced antibacterial properties of orthopedic implants by titanium nanotube surface modification: a review of current techniques</p>

Decorating Nanostructured Surfaces with Antimicrobial Peptides to Efficiently Fight Bacteria

Considerations for Designing Next-Generation Composite Dental Materials

Contact Info

Product

Resources

About