Antibiotic Pollution of Planktonic Ecosystems: A Review Focused on Community Analysis and the Causal Chain Linking Individual- and Community-Level Responses

Gunathilaka, M. D. K. L.; Bao, Siyi; Liu, Xiaoxuan; Li, Ya; Pan, Ying

doi:10.1021/acs.est.2c06787

Cited by 51 publications

(13 citation statements)

References 113 publications

(279 reference statements)

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“…[e] LC 50 : Lethal concentration that kills 50 % of the exposed zebrafish larvae, [f] (LCL: Lower confidence limit, UCL: Upper confidence limit). [b] (25.675-34.014) 44.590 [c] (40.456-48.608) 58.540 [b] (53.758-63.861) 2 3a 37.841 [b] ( 36.562 [b] (30.011-42.248) 54.457 [b] ( 55.797 [b] (50.873-61.180) 12 3k 32.061 [b] (28.167-35.563) 39.964 [b] (34.715-43.932) 54.989 [b] (50.132-60.252) 13 3l 45.572 [c] (41.010-50.032) 75.915 [d] (80.173-107.624) 110.005 (96.880-130.642) [a-d] Distinct lowercase letter in the line indicate significant difference between the experimental groups, [e] LC 50 : Lethal concentration that kills 50 % of the exposed zebrafish larvae, [f] (LCL: Lower confidence limit, UCL: Upper confidence limit).…”

Section: Discussionmentioning

confidence: 99%

“…After incubation, bacterial and fungal growth was noticed. Standards for anti‐bacterial activity were erythromycin and levofloxacin, while fluconazole was used to measure antifungal activity [44] . The millimeter dimensions of the resulting inhibitory zones were used as a benchmark for anti‐microbial activity.…”

Section: Methodsmentioning

confidence: 99%

“…Standards for anti-bacterial activity were erythromycin and levofloxacin, while fluconazole was used to measure antifungal activity. [44] The millimeter dimensions of the resulting inhibitory zones were used as a benchmark for anti-microbial activity. As a negative control, solvent controls (DMSO) were included in all experiments.…”

Section: Anti-microbial Activity Of Benzimidazole Compoundsmentioning

confidence: 99%

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Facile Synthesis of Benzimidazoles via Oxidative Cyclization of Acyclic Monoterpene Aldehyde with Diamines: Studies on Antimicrobial and in Vivo Evaluation of Zebrafish

Vaithiyalingam,

Mohan Kumar,

Kamaraj

et al. 2023

Chemistry & Biodiversity

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Citral (1a), a bioactive component of Cymbopogon citratus (lemongrass) could be isolated and semi‐synthetic analogs synthesized with improved therapeutic properties. Herein we first report describes citral (1a) as a primary material for the synthesis of benzimidazole derivatives between various o‐phenylenediamines (2a–l) in the presence of Diisopropylethylamine (DIPEA) as a commercially available environmentally benign base, ethanol as a green solvent and the yield of all benzimidazole derivatives (3a–l) was between 68–76 %; The semi‐synthetically prepared benzimidazole derivatives (3a–l) were assessed for their anti‐bacterial and anti‐fungal properties. The benzimidazole compounds (3a–b, and 3g–j) exhibit good anti‐microbial activity. In addition, in silico study was carried out to determine the specific binding affinity of the diamine halogen substituted benzimidazole derivatives to the specific target proteins. In silico analysis revealed a high correlation between docking results and experimental results. Finally, benzimidazole demonstrated significant antibacterial and antifungal activity. Zebrafish embryos were subjected to In vivo toxicological test found that all of the benzimidazole compounds (3a–l) were non‐toxic and had low embryotoxicity after 96 h, with an LC50 of 36.425 μg, which could facilitate the design of novel antimicrobial agents using a cost‐effective method.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Anti-microbial Activity Of Benzimidazole Compoundsmentioning

confidence: 99%

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Facile Synthesis of Benzimidazoles via Oxidative Cyclization of Acyclic Monoterpene Aldehyde with Diamines: Studies on Antimicrobial and in Vivo Evaluation of Zebrafish

Vaithiyalingam,

Mohan Kumar,

Kamaraj

et al. 2023

Chemistry & Biodiversity

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“…Consequently, not only antibiotic residues but also antibiotic‐resistant bacteria can spread and accumulate in various ecological environments, such as groundwater, surface water, watercourses, soil, and crops, depending on the properties of the antibiotics. The introduction of these substances into the soil can adversely affect microorganisms responsible for nutrient cycling and pollutant degradation (Gunathilaka et al., 2023). This contamination can lead to the accumulation of these substances in the plant tissues of crops grown in fertilized fields or irrigated with contaminated water, potentially negatively impacting human and animal health by contributing to the development of allergies and antibiotic resistance.…”

Section: Introductionmentioning

confidence: 99%

Occurrence of antimicrobials in animal manure‐amended soils around the breeding farms: The case of the Saigon River (southern Vietnam)

Tuyet¹,

Tuc

Nghia

et al. 2023

Environmental Quality Mgmt

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The excessive use of antimicrobials in animal rearing and the associated environmental hazards have become a pressing issue. Animal agriculture is often viewed as a significant contributor to environmental degradation due to the residues of antimicrobials. It is a common practice to use livestock waste as a soil enhancer in farming. Despite some research into antimicrobials, there is room for more comprehensive data regarding these pollutants in animal farming environments. A handful of earlier studies have identified antimicrobials in animal waste. This research undertook the task of examining and evaluating soils amended with animal waste (from chickens, cows, and pigs) for the presence of seven specific antimicrobials. The antimicrobials under scrutiny included trimethoprim (TRI), ormethoprim (ORM), ofloxacin (OFL), norfloxacin (NOR), tetracycline (TET), chlortetracycline (CTE), and tylosin (TLS). Soil samples were collected from areas surrounding breeding farms located upstream of the Sai Gon River. These samples were then subjected to laboratory analysis, which involved solid‐phase extraction using ultrasonic waves and the application of high‐performance liquid chromatography‐tandem mass spectrometry (LCMS/MS) to identify the antimicrobials. TRI, which had the highest average concentration (2.603–91.304 μg/kg), and OFL, with the second highest average concentration (1.815–15.832 μg/kg), were detected in all soil samples amended with manure. CTE, with the third highest average concentration, was found in soils amended with cow and pig waste (1.625–15.486 μg/kg). ORM and TE, with lower average concentrations (0.595–1.318 μ and 11.537–13.569 μg/kg, respectively), were only detected in soils amended with chicken waste, while NOR was only found in soils amended with cow waste. These findings indicate that the use of antimicrobials in animal farming can negatively impact the soil ecosystem. Consequently, these results can contribute to the creation of guidelines for monitoring antimicrobial residues in agricultural ecosystems.

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“…19−21 Reproductive toxicity effects following environmental exposures to antibiotics will likely impact larval offspring and thus further change the health and function of populations within the aquatic system. 22,23 Therefore, characterizing the influence of an intergenerational trans- Nevertheless, the quantitative detection of the changes between antibiotic concentrations in parents and offspring has seldom been conducted during intergenerational transmission, with the overall mechanism of transfer not currently well understood. Whether antibiotics are persistent or could be removed within several generations in fish species requires verification.…”

Section: Introductionmentioning

confidence: 99%

Maternal or Paternal Antibiotics? Intergenerational Transmission and Reproductive Toxicity in Zebrafish

Xu,

Pu,

Jiang

et al. 2023

Environ. Sci. Technol.

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Despite the known direct toxicity of various antibiotics to aquatic organisms, the potential chronic impact through intergenerational transmission on reproduction remains elusive. Here, we exposed zebrafish to a mixture of 15 commonly consumed antibiotics at environmentally relevant concentrations (1 and 100 μg L −1 ) with a cross-mating design. A high accumulation of antibiotics was detected in the ovary (up to 904.58 ng g −1 ) and testis (up to 1704.49 ng g −1 ) of F0 fish. The transmission of antibiotics from the F0 generation to the subsequent generation (F1 offspring) was confirmed with a transmission rate (k i ) ranging from 0.11 to 2.32. The maternal transfer of antibiotics was significantly higher, relative to paternal transfer, due to a greater role of transmission through ovarian enrichment and oviposition compared to testis enrichment. There were similar impairments in reproductive and developmental indexes on F1 eggs found following both female and male parental exposure. Almost all antibiotics were eliminated in F2 eggs in comparison to F1 eggs. However, there were still reproductive and developmental toxic responses observed in F2 fish, suggesting that antibiotic concentration levels were not the only criterion for evaluating the toxic effects for each generation. These findings unveil the intergenerational transmission mechanism of antibiotics in fish models and underscore their potential and lasting impact in aquatic environments.

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Antibiotic Pollution of Planktonic Ecosystems: A Review Focused on Community Analysis and the Causal Chain Linking Individual- and Community-Level Responses

Cited by 51 publications

References 113 publications

Facile Synthesis of Benzimidazoles via Oxidative Cyclization of Acyclic Monoterpene Aldehyde with Diamines: Studies on Antimicrobial and in Vivo Evaluation of Zebrafish

Facile Synthesis of Benzimidazoles via Oxidative Cyclization of Acyclic Monoterpene Aldehyde with Diamines: Studies on Antimicrobial and in Vivo Evaluation of Zebrafish

Occurrence of antimicrobials in animal manure‐amended soils around the breeding farms: The case of the Saigon River (southern Vietnam)

Maternal or Paternal Antibiotics? Intergenerational Transmission and Reproductive Toxicity in Zebrafish

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