Antibiotic prescribing patterns and hospital admissions with respiratory and urinary tract infections

Fernández-Urrusuno, Rocío; González, Miguel Pedregal; Rojas, M. Amparo Torrecilla

doi:10.1007/s00228-008-0514-6

Cited by 5 publications

(6 citation statements)

References 25 publications

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“…The studies in which multiple infection types were explored simultaneously generally reported conflicting findings. Some studies indicated that antibiotic prescribing in primary care was associated with a reduction or no increase in hospitalisation [22,31], whereas one study reported higher rates of hospitalisation [18], and yet another reported no association between antibiotic prescribing in primary care and antibiotic resistance [30]. It is unlikely that the examination of multiple infection types explains these different findings, given that most of the studies focussed only on RTIs and UTIs [18,30,31].…”

Section: Discussionmentioning

confidence: 99%

“…Some studies indicated that antibiotic prescribing in primary care was associated with a reduction or no increase in hospitalisation [22,31], whereas one study reported higher rates of hospitalisation [18], and yet another reported no association between antibiotic prescribing in primary care and antibiotic resistance [30]. It is unlikely that the examination of multiple infection types explains these different findings, given that most of the studies focussed only on RTIs and UTIs [18,30,31]. However, different study designs were adopted such that the target population of the Urrusuno et al study was GPs, whereas other studies focussed on large representative samples of patients using administrative data [18].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, in a study assessing the impact of a national antimicrobial stewardship programme, there was evidence, albeit indirect, that reduced antibiotic prescribing in primary care did not result in increased hospital admissions [22]. Conversely, a large GP-based study showed how a higher rate of antibiotic prescribing in primary care was linked to a significantly higher number of adjusted hospital admissions due to complications from RTIs and UTIs regardless of the type of antibiotic prescribed or the age or postgraduate training or appointment (permanent or nonpermanent) of the GP [18]. Another study by Van Staa et al demonstrated how the risk of infection-related hospital admissions was highest in patients with frequent prior antibiotic use [32].…”

Section: Multiple Infection Typesmentioning

confidence: 99%

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Primary Care Antibiotic Prescribing and Infection-Related Hospitalisation

Menting,

Redican,

Murphy

et al. 2023

Antibiotics

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Inappropriate prescribing of antibiotics has been widely recognised as a leading cause of antimicrobial resistance, which in turn has become one of the most significant threats to global health. Given that most antibiotic prescriptions are issued in primary care settings, investigating the associations between primary care prescribing of antibiotics and subsequent infection-related hospitalisations affords a valuable opportunity to understand the long-term health implications of primary care antibiotic intervention. A narrative review of the scientific literature studying associations between primary care antibiotic prescribing and subsequent infection-related hospitalisation was conducted. The Web of Science database was used to retrieve 252 potentially relevant studies, with 23 of these studies included in this review (stratified by patient age and infection type). The majority of studies (n = 18) were published in the United Kingdom, while the remainder were conducted in Germany, Spain, Denmark, New Zealand, and the United States. While some of the reviewed studies demonstrated that appropriate and timely antibiotic prescribing in primary care could help reduce the need for hospitalisation, excessive antibiotic prescribing can lead to antimicrobial resistance, subsequently increasing the risk of infection-related hospitalisation. Few studies reported no association between primary care antibiotic prescriptions and subsequent infection-related hospitalisation. Overall, the disparate results in the extant literature attest to the conflicting factors influencing the decision-making regarding antibiotic prescribing and highlight the necessity of adopting a more patient-focussed perspective in stewardship programmes and the need for increased use of rapid diagnostic testing in primary care.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Multiple Infection Typesmentioning

confidence: 99%

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Primary Care Antibiotic Prescribing and Infection-Related Hospitalisation

Menting,

Redican,

Murphy

et al. 2023

Antibiotics

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“…Disease-specific QIs cannot be applied to this type of data, and therefore, drug-specific QIs are more frequently used. [ 23 , 27–30 , 40 ]…”

Section: Discussionmentioning

confidence: 99%

Quality assessment of diagnosis and antibiotic treatment of infectious diseases in primary care: a systematic review of quality indicators

Saust

Monrad

Hansen

et al. 2016

Scandinavian Journal of Primary Health Care

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ObjectiveTo identify existing quality indicators (QIs) for diagnosis and antibiotic treatment of patients with infectious diseases in primary care.DesignA systematic literature search was performed in PubMed and EMBASE. We included studies with a description of the development of QIs for diagnosis and antibiotic use in patients with infectious diseases in primary care. We extracted information about (1) type of infection; (2) target for quality assessment; (3) methodology used for developing the QIs; and (4) whether the QIs were developed for a national or international application. The QIs were organised into three categories: (1) QIs focusing on the diagnostic process; (2) QIs focusing on the decision to prescribe antibiotics; and (3) QIs concerning the choice of antibiotics.ResultsEleven studies were included in this review and a total of 130 QIs were identified. The majority (72%) of the QIs were focusing on choice of antibiotics, 22% concerned the decision to prescribe antibiotics, and few (6%) concerned the diagnostic process. Most QIs were either related to respiratory tract infections or not related to any type of infection. A consensus method (mainly the Delphi technique), based on either a literature study or national guidelines, was used for the development of QIs in all of the studies.ConclusionsThe small number of existing QIs predominantly focuses on the choice of antibiotics and is often drug-specific. There is a remarkable lack of diagnostic QIs. Future development of new QIs, especially disease-specific QIs concerning the diagnostic process, is needed.Key Points In order to improve the use of antibiotics in primary care, measurable instruments, such as quality indicators, are needed to assess the quality of care being provided.A total of 11 studies were found, including 130 quality indicators for diagnosis and antibiotic treatment of infectious diseases in primary care.The majority of the identified quality indicators were focusing on the choice of antibiotics and only a few concerned the diagnostic process.All quality indicators were developed by means of a consensus method and were often based on literature studies or guidelines.

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“…The dandelion is a well‐known herb that is commonly used in traditional Chinese herbal medicine, and its leaves have multiple functions, including reducing swelling, and ameliorating inflammatory diseases 8,9 . Its functions of “clearing heat‐toxins” and “detumescence” are used in the treatment of upper respiratory and urinary tract infections 10 . A recent study showed that liquid dandelion root extract is efficacious against lipopolysaccharide‐induced inflammation in acute lung lesions.…”

Section: Introductionmentioning

confidence: 99%

Ameliorative effect of dandelion (Taraxacum officinale) peptides on benzo(a)pyrene‐induced oxidative stress and inflammation in human umbilical vein endothelial cells

Cai

Yan

et al. 2022

Journal of Peptide Science

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Dandelion (Taraxacum officinale) is widely consumed as a health food and a traditional medicine. However, the protective effect of dandelion bio‐active peptides (DPs) against polycyclic aromatic hydrocarbon‐induced blood vessel inflammation and oxidative damage is not well documented. In the current study, four novel DPs were isolated using an activity tracking method. The protective activity of the DPs against benzo(a)pyrene (Bap)‐induced human umbilical vein endothelial cell (HUVEC) damage was explored. The results indicated that DP‐2 [cycle‐(Thr‐His‐Ala‐Trp)] effectively inhibited Bap‐induced reactive oxygen species (ROS) and malondialdehyde (MDA) overproduction and reinforced antioxidant enzyme activity while inhibiting the production of inflammatory factors in HUVECs. Moreover, DP‐2 increased NAD(P)H:quinone oxidoreductase 1, heme oxygenase‐1, and nuclear factor E2‐releated factor 2 expression levels by activating the PI3K/Akt signaling pathway. In addition, DP‐2 attenuated Bap‐induced HUVEC apoptosis via the Bcl‐2/Bax/cytochrome c apoptotic pathway. These results suggest that DP‐2 is a promising compound for protecting HUVECs from Bap‐induced inflammatory and oxidative damage.

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Antibiotic prescribing patterns and hospital admissions with respiratory and urinary tract infections

Cited by 5 publications

References 25 publications

Primary Care Antibiotic Prescribing and Infection-Related Hospitalisation

Primary Care Antibiotic Prescribing and Infection-Related Hospitalisation

Quality assessment of diagnosis and antibiotic treatment of infectious diseases in primary care: a systematic review of quality indicators

Ameliorative effect of dandelion (Taraxacum officinale) peptides on benzo(a)pyrene‐induced oxidative stress and inflammation in human umbilical vein endothelial cells

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