Antibiotic Pretreatment of Hydrogel Ureteral Stent

John, Tony T.; Rajpurkar, Atul; Smith, Gerald R.; Fairfax, Marilynn R.; Triest, Jeffrey A.

doi:10.1089/end.2007.9904

Cited by 49 publications

(29 citation statements)

References 23 publications

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“…Darouiche et al [34 ] found that urethral catheters soakedin chlorhexidine andprotaminesulphate were highlyresistant to biofilm formation in vitro and significantly resisted E. coli attachment in a rabbit model. Although it is not likely that this or other antibiotic-protamine sulphate combinations would prove valuable for long-term ureteral stenting, they could be beneficial for short-term stenting as well as for hydrating hydrogels [35] containing other longterm antibiofilm strategies, thus providing additional antimicrobial benefits.…”

Section: Biofilm Prevention and Treatment Strategiesmentioning

confidence: 99%

Eliminating biofilm from ureteral stents: the holy grail

Denstedt

Cadieux

2009

Current Opinion in Urology

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Despite the current lack of a completely biofilm-resistant device, coating or treatment strategy, continued research into the causation of bacterial biofilm formation and the continued development of novel antibacterial, antifouling and antibiofilm compounds is promising. Future work should be aimed at more rigorous testing of candidate coatings from both physical and bacterial challenge standpoints as well as increased in-vivo investigation via clinical trials.

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Section: Biofilm Prevention and Treatment Strategiesmentioning

confidence: 99%

Eliminating biofilm from ureteral stents: the holy grail

Denstedt

Cadieux

2009

Current Opinion in Urology

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“…Some strategies have used chemical approaches such as antiadhesins/polymeric coatings (Cassinelli et al 2000;van de Belt et al 2001;von Bismarck et al 2001;John et al 2007;Johansson et al 2008), quorum sensing inhibitors (Francolini et al 2004;Cirioni et al 2006;Antoniani et al 2010), biosynthesis inhibitors (Ueda et al 2009), biofilm dispersal agents (Raad et al 2007;Kim et al 2008;Barraud et al 2009;Cai et al 2009;Davies & Marques 2009) and natural products (Bjarnsholt et al 2007;Kalishwaralal et al 2010;Kostenko et al 2010;Wu et al 2011), among others. Physical methods have also been investigated, including ultrasound waves (Ensing et al 2005), low frequency vibrations (Bandara et al 2014) and other methods (Di Poto et al 2009).…”

Section: Discussionmentioning

confidence: 99%

Magnetic fields suppressPseudomonas aeruginosabiofilms and enhance ciprofloxacin activity

et al. 2015

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Due to the refractory nature of pathogenic microbial biofilms, innovative biofilm eradication strategies are constantly being sought. Thus, this study addresses a novel approach to eradicate Pseudomonas aeruginosa biofilms. Magnetic nanoparticles (MNP), ciprofloxacin (Cipro), and magnetic fields were systematically evaluated in vitro for their relative anti-biofilm contributions. Twenty-four-hour biofilms exposed to aerosolized MNPs, Cipro, or a combination of both, were assessed in the presence or absence of magnetic fields (Static one-sided, Static switched, Oscillating, Static + oscillating) using changes in bacterial metabolism, biofilm biomass, and biofilm imaging. The biofilms exposed to magnetic fields alone exhibited significant metabolic and biomass reductions (p < 0.05). When biofilms were treated with a MNP/Cipro combination, the most significant metabolic and biomass reductions were observed when exposed to static switched magnetic fields (p < 0.05). The exposure of P. aeruginosa biofilms to a static switched magnetic field alone, or co-administration with MNP/Cipro/MNP + Cipro appears to be a promising approach to eradicate biofilms of this bacterium.

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“…For example, ureteral stents made of an olefinic block copolymer were coated with a hydrogel that was subsequently impregnated with antibiotics [97]. These stents demonstrated in vitro antimicrobial activity for 3–16 days against common ureteral pathogens.…”

Section: Requirements For Local Antimicrobial Delivery Systems Andmentioning

confidence: 99%

Beyond conventional antibiotics — New directions for combination products to combat biofilm

Bayramov

Neff

2017

Advanced Drug Delivery Reviews

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Medical device related infections are a significant and growing source of morbidity and mortality. Biofilm formation is a common feature of medical device infections that is not effectively prevented or treated by systemic antibiotics. Antimicrobial medical device combination products provide a pathway for local delivery of antimicrobial therapeutics with the ability to achieve high local concentrations while minimizing systemic side effects. In this review, we present considerations for the design of local antimicrobial delivery systems, which can be facilitated by modeling local pharmacokinetics in the context of the target device application. In addition to the need for local delivery, a critical barrier to progress in the field is the need to incorporate agents effective against biofilm. This article aims to review key properties of antimicrobial peptides that make them well suited to meet the demands of the next generation of antimicrobial medical devices, including broad spectrum activity, rapid and biocidal mechanisms of action, and efficacy against biofilm.

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Antibiotic Pretreatment of Hydrogel Ureteral Stent

Cited by 49 publications

References 23 publications

Eliminating biofilm from ureteral stents: the holy grail

Eliminating biofilm from ureteral stents: the holy grail

Magnetic fields suppressPseudomonas aeruginosabiofilms and enhance ciprofloxacin activity

Beyond conventional antibiotics — New directions for combination products to combat biofilm

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