Antibiotic Prophylaxis in Open-Heart Surgery: A Comparison of Cefamandole, Cefuroxime, and Cefazolin

Gentry, Layne O.; Zeluff, Barry; Cooley, Denton A.

doi:10.1016/s0003-4975(10)65890-0

Cited by 40 publications

(11 citation statements)

References 11 publications

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“…As a prophylaxis, and study drug, we used cefuroxime, because cephalosporins are frequently prescribed for prophylaxis in cardiac surgery [21][22][23] . The dosing schedules for the cephalosporins (cefuroxime) administration as recommended by the manufacture's are of general validity and can serve as a basis for prophylactic administration in general surgical interventions.…”

Section: Discussionmentioning

confidence: 99%

Tissue and Plasma Concentrations of Antibiotic During Cardiac Surgery With Cardiopulmonary Bypass - Microdialysis Study

Pojar

Mandak²,

Maláková³

et al. 2008

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Aim: Surgical-site infections are very serious complications of cardiac operations. Use of cardiopulmonary bypass (CPB) is associated with profound physiological changes, which aff ects the pharmacokinetic behaviour of prophylactic antibiotics. The aim of this study was to monitor tissue concentrations of cefuroxime in peripheral tissue (skeletal muscle) during cardiac surgery using CPB by means of a microdialysis.Methods: Eleven adult patients operated on using CPB were included in the study. Cefuroxime was the prophylactic antibiotic and study drug given. Microdialysis was performed by probe CMA 60 inserted into the patient's left deltoid muscle. Samples of dialysates were collected at intervals: before CPB, each 30 minutes of CPB and at the end of CPB. Samples of blood were collected at intervals: incision, start of CPB, each 30 minutes of CPB, at the end of CPB and at the end of surgery.

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Section: Discussionmentioning

confidence: 99%

Tissue and Plasma Concentrations of Antibiotic During Cardiac Surgery With Cardiopulmonary Bypass - Microdialysis Study

Pojar

Mandak²,

Maláková³

et al. 2008

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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“…Almost certainly, additional important risk factors for specific procedures need to be identified and incorporated into such an index [51], such as antibiotic prophylaxis during procedures in which it has been shown to be effective but not universally adopted [52][53][54][55][56][57].…”

Section: Discussionmentioning

confidence: 99%

Surgical Site Infection (SSI) Rates in the United States, 1992–1998: The National Nosocomial Infections Surveillance System Basic SSI Risk Index

Gaynes¹,

Culver²,

Horan³

et al. 2001

CLIN INFECT DIS

469

281

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By use of the National Nosocomial Infections Surveillance (NNIS) System's surgical patient surveillance component protocol, the NNIS basic risk index was examined to predict the risk of a surgical site infection (SSI). The NNIS basic SSI risk index is composed of the following criteria: American Society of Anesthesiologists score of 3, 4, or 5; wound class; and duration of surgery. The effect when a laparoscope was used was also determined. Overall, for 34 of the 44 NNIS procedure categories, SSI rates increased significantly (P< .05) with the number of risk factors present. With regard to cholecystectomy and colon surgery, the SSI rate was significantly lower when the procedure was done laparoscopically within each risk index category. With regard to appendectomy and gastric surgery, use of a laparoscope affected SSI rates only when no other risk factors were present. The NNIS basic SSI index is useful for risk adjustment for a wide variety of procedures. For 4 operations, the use of a laparoscope lowered SSI risk, requiring modification of the NNIS basic SSI risk index.

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“…In contrast, Gentry and colleagues (9) found no differences (14,28) in which wound infection pathogens were available, the microbiology of these postoperative infections indicated that, despite prophylaxis, staphylococci continued to produce infectious complications (Table 2). S. aureus and S. epidermidis accounted for more than one-half of the wound infections among cefazolin recipients.…”

Section: Introductionmentioning

confidence: 93%

Reappraisal of the antistaphylococcal activities of first-generation (narrow-spectrum) and second-generation (expanded-spectrum) cephalosporins

Sabath

1989

Antimicrob Agents Chemother

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Antibiotic Prophylaxis in Open-Heart Surgery: A Comparison of Cefamandole, Cefuroxime, and Cefazolin

Cited by 40 publications

References 11 publications

Tissue and Plasma Concentrations of Antibiotic During Cardiac Surgery With Cardiopulmonary Bypass - Microdialysis Study

Tissue and Plasma Concentrations of Antibiotic During Cardiac Surgery With Cardiopulmonary Bypass - Microdialysis Study

Surgical Site Infection (SSI) Rates in the United States, 1992–1998: The National Nosocomial Infections Surveillance System Basic SSI Risk Index

Reappraisal of the antistaphylococcal activities of first-generation (narrow-spectrum) and second-generation (expanded-spectrum) cephalosporins

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