Antibiotic Resistance and the Prospects of Medicinal Plants in the Treatment of Salmonellosis

Aliero, AA; Ibrahim, A

doi:10.5772/29241

Cited by 5 publications

(8 citation statements)

References 141 publications

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“…This was the highest concentration tested because in vitro MIC values greater than 1000 μg ml À1 were considered with no relevance from a clinical perspective. 44,45 Then, 2 μl of the calibrated microbial suspensions were inoculated onto the plates and incubated aerobically at 37 C. The inhibition of microbial growth was determined by comparison with control plates (including equal amounts of solvents) after an incubation period of 24 and 48 h for bacteria and fungi, respectively. DMSO was used as a co-solvent and did not affect the viability of microorganisms in a final concentration lower than 5%.…”

Section: Minimum Inhibitory Concentration (Mic) Determinationsmentioning

confidence: 99%

Computational studies, antimicrobial activity, inhibition of biofilm production, and safety profile of the cadmium complex of 1,10‐phenanthroline and cyanoguanidine

Falkievich

Medina

Alegre

et al. 2022

Applied Organom Chemis

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We have previously determined the crystal structure of the metal complex [Cd (1,10-phenanthroline) 2 (SO 4 )H 2 O]cyanoguanidine•5H 2 O that was characterized by spectroscopic measurements. The antibacterial activity was also determined by the agar diffusion test (zones of inhibition). In the present work, calculations based on density functional theory were performed to determine the contributions of the two different tautomers of cyanoguanidine to the vibrational IR and Raman experimental spectra. Moreover, the antimicrobial (antibacterial and antifungal) activity of the complex and cadmium ion was assessed and the minimum inhibitory concentration (MIC) was determined.The complexation increased the antimicrobial activity against Pseudomonas aeruginosaATCC 27853 and inhibited the biofilm production of this pathogen.Antimicrobial studies were coupled with the evaluation of safety, using the Artemia salinaand Ames test. At the concentrations tested, the cadmium complex behaved as a non-mutagenic and non-toxic compound. Therefore, the interaction of cadmium (II) with N and O-containing ligands may provide a promising strategy for the development of novel and safe drugs with antimicrobial activity.

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Section: Minimum Inhibitory Concentration (Mic) Determinationsmentioning

confidence: 99%

Computational studies, antimicrobial activity, inhibition of biofilm production, and safety profile of the cadmium complex of 1,10‐phenanthroline and cyanoguanidine

Falkievich

Medina

Alegre

et al. 2022

Applied Organom Chemis

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“…Based up on their TLC results of further fractionation the first six fractions (1)(2)(3)(4)(5)(6) showed the same and one major spot at (Rf=0.72) in (70:30) ethyl acetate/n-hexane solvent system. yellowish powder was obtained after washing continuously with n-hexane by monitored with TLC and coded as compound TN-3.…”

Section: Isolation Of Compounds From Crude Dichloromethane/ Methanol ...mentioning

confidence: 99%

“…The heavy reliance on herbal remedies is increasing from time to time due to resistance of microbial pathogens to the existing convengtional drugs [5]. In the developing countries, these alternative drugs are neither readily available nor affordable and thusmedicinal plants have been used as replacements [6]. These plants are, thus considered as rich resources of ingredients which can be used in drug development and synthesis.…”

Section: Introduction Background Informationmentioning

confidence: 99%

Phytochemical Investigation and Antimicrobial Study of Some Selected Traditional Medicinal Plants from North Gondar Zone

2022

JTMA

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Teclea nobilis is one of an endemic species to Ethiopia. It is used as a traditional medicine to treat analgesics and other disorders. Although many species of the genus Teclea have been investigated for their chemical constituents, there is no much prior report on the investigation of chemical constituents of root of Teclea nobilis. Phytochemical screening of the C6 H14, CH2 Cl2 ,CH2 Cl2 /CH3 OH (1:1) and CH3 OH root extracts of the plant revealed the presence of alkaloids, flavonoids, terpenes, phenols, tannins and glycosides.Chromatographic separation using column chromatography of CH2 Cl2 /CH3 OH (1:1) result in isolation of three compounds namely compound TN1(0.06%), TN2(0.04%)and TN3(0.05%).Structure are proposed for Compound TN1 and compound TN2 .Compound TN3 was not fully characterized due to lack of adequate spectral data.

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“…El vocablo cadmio significa calamina, nombre que recibía antiguamente el carbonato de cinc. El elemento cadmio lleva este nombre porque fue descubierto en Alemania en 1817 por Friedrich Stromeyer como una impureza en el carbonato de cinc [62]. El cadmio es un metal no fisiológico que presenta reacciones de toxicidad variadas y en su forma catiónica Cd(II) presenta fuertes analogías con el zinc y el calcio, lo cual da cuenta de sus principales efectos tóxicos.…”

Section: Elementos Tóxicos (Cadmio)unclassified

“…Espectros electrónicos de absorción y de reflectancia difusa para los complejos (1) y(2) (posiciones de las bandas en nm). , coeficientes de extinción molar en M -1 cm -1 como gas inerte[23,62]. Las FEM se midieron con un pehachímetro Schott Gerate TS165 de las siguientes características: rango -2.000 a 20.000 pH, Resolución: 0.1/0.01/0.001 pH; 1/0.1 mV y 0.1 ⁰C y precisión relativa: ± 0.002 pH, ±0.1 mV a 25 ⁰C y ± 0.2 ⁰C.…”

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Estudio de complejos metálicos con ligandos de interés biológico

Tévez¹,

Leonor²

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Esta tesis sostiene como objetivo sintetizar nuevos compuestos de coordinación empleando como centro metálico a los cationes de Cu(II), Zn(II) y Cd(II) y como ligando orgánicos, las moléculas de cianoguanidina y o-fenantrolina. Además se aborda el estudio de las nuevas especies complejas desde una perspectiva teórica y experimental para brindar información respecto de su estructura y sus propiedades físicoquímicas y biológicas. Entre las determinaciones realizadas destacamos aquellas que han permitido conocer la estructura del nuevo complejo (IR, Raman, cristalográfico), su solubilidad en distintos solventes y mezclas de solventes (especialmente agua y agua/dmso), estabilidad térmica y en solución, especiación en un rango amplio de pH, actividad sobre sistemas enzimáticos (superóxido dismutasa y fosfatasa alcalina), actividad antibacteriana y antifúngica sobre las cepas mencionadas anteriormente (algunas de colección y otras de aislamientos autóctonos) y actividad post antimicrobiana.

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Antibiotic Resistance and the Prospects of Medicinal Plants in the Treatment of Salmonellosis

Cited by 5 publications

References 141 publications

Computational studies, antimicrobial activity, inhibition of biofilm production, and safety profile of the cadmium complex of 1,10‐phenanthroline and cyanoguanidine

Computational studies, antimicrobial activity, inhibition of biofilm production, and safety profile of the cadmium complex of 1,10‐phenanthroline and cyanoguanidine

Phytochemical Investigation and Antimicrobial Study of Some Selected Traditional Medicinal Plants from North Gondar Zone

Estudio de complejos metálicos con ligandos de interés biológico

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