Antibiotic resistance in early periprosthetic joint infection

Ravi, Saiprasad; Zhu, Mark; Luey, Chris; Young, Simon W.

doi:10.1111/ans.13720

Cited by 46 publications

(36 citation statements)

References 43 publications

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“…32–38 In primary and revision periprosthetic joint infections (PJIs), the most common infecting organisms were S. aureus and coagulase-negative Staphylococci (CNS), 34–36 and most strains were resistant to at least one antibiotic (Table 2). 32–37 Alarmingly, in some cases, 36 CNS resistance to both methicillin and gentamicin seems to be much higher than S. aureus and has been increasing, which is a concern for future antibiotic prophylaxis.…”

Section: Antibiotic Resistance Profiles In Orthopaedic Implant-assmentioning

confidence: 99%

“…32,33 Numerous clinical studies have been reported about orthopedic implant-associated infections, along with increasing clinical studies focusing on antibiotic resistance and its prevalence in orthopedic implant-associated infections. [32][33][34][35][36][37][38] In primary and revision periprosthetic joint infections (PJIs), the most common infecting organisms were S. aureus and coagulasenegative Staphylococci (CNS), [34][35][36] and most strains were resistant to at least one antibiotic ( Table 2). [32][33][34][35][36][37] Alarmingly, in some cases, 36 CNS resistance to both methicillin and gentamicin seems to be much higher than S. aureus and has been increasing, which is a concern for future antibiotic prophylaxis.…”

Section: A N T I B I O T I C R E S I S T a N C E P R O F I L E S I N mentioning

confidence: 99%

“…Antibiotic alternatives may reduce the use of antibiotics; however, the role of non-antibiotic drugs in developing antibiotic resistance has not been examined yet and is not clear. The majority of research to date focuses on infections formed by a single species of bacteria; however, most infections are polymicrobial (consisting of two or more bacterial species) [33][34][35]67 which is more difficult to treat. 68 It is not clear whether polymicrobial infections have higher antibiotic resistance compared to monomicrobial infections and the role of each individual microorganism in contributing to antibiotic resistance is also unknown.…”

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Bacteria antibiotic resistance: New challenges and opportunities for implant‐associated orthopedic infections

Webster

2017

Journal Orthopaedic Research

760

463

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There has been a dramatic increase in the emergence of antibiotic resistant bacterial strains, which has made antibiotic choices for infection control increasingly limited and more expensive. In the U.S. alone, antibiotic resistant bacteria cause at least 2 million infections and 23,000 deaths a year resulting in a $55-70 billion per year economic impact. Antibiotics are critical to the success of surgical procedures including orthopaedic prosthetic surgeries, and antibiotic resistance is occurring in nearly all bacteria that infect people, including the most common bacteria that cause orthopaedic infections, such as Staphylococcus aureus (S. aureus). Most clinical cases of orthopaedic surgeries have shown that patients infected with antibiotic resistant bacteria, such as methicillin resistant S. aureus (MRSA), are associated with increased morbidity and mortality. This paper reviews the severity of antibiotic resistance at the global scale, the consequences of antibiotic resistance, and the pathways bacteria used to develop antibiotic resistance. It highlights the opportunities and challenges in limiting antibiotic resistance through approaches like the development of novel, non-drug approaches to reduce bacteria functions related to orthopaedic implant-associated infections.

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Section: Antibiotic Resistance Profiles In Orthopaedic Implant-assmentioning

confidence: 99%

Section: A N T I B I O T I C R E S I S T a N C E P R O F I L E S I N mentioning

confidence: 99%

mentioning

confidence: 99%

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Bacteria antibiotic resistance: New challenges and opportunities for implant‐associated orthopedic infections

Webster

2017

Journal Orthopaedic Research

760

463

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“…Staphylococci, the most common PJI pathogens, access the periprosthetic space either during the perioperative period or through hematogenous dissemination 3 . Recent reports suggest that antibioticresistant strains are becoming more common 4,5 .…”

Section: Introductionmentioning

confidence: 99%

Assessing the Role of Daptomycin as Antibiotic Therapy for Staphylococcal Prosthetic Joint Infection

Carli

Miller

Kapadia

et al. 2020

J. Bone Joint Infect.

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Background: The role of daptomycin, a potent, safe, convenient anti-staphylococcal antibiotic, in treatment of prosthetic joint infection (PJI) is unclear. We evaluated our experience with the largest cohort of patients with staphylococcal PJI managed with daptomycin. Methods: A cohort of staphylococcal hip and knee PJI treated with daptomycin was identified by hospital records from 2009 to 2016. All cases met Musculoskeletal Infection Society International Consensus criteria for PJI. The primary endpoint was 2 year prosthesis retention. Univariate analyses and regression statistics were calculated. Results: 341 patients with staphylococcal PJI were analyzed. 154 two-stages (77%) and 74 DAIR procedures (52%) met criteria for treatment success at 2 years. 77 patients were treated with daptomycin, of which 34 two-stages (68%) and 15 DAIRs (56%) achieved treatment success. Pairwise and regression analysis found no association between treatment success and daptomycin use. Organism (DAIR only) and Charlson Comorbidity Index scores (DAIR and two-stage) were significantly associated with treatment outcome. Six daptomycin patients (7.8%) had adverse side effects. Discussion: Daptomycin fared no better or worse than comparable antibiotics in a retrospective cohort of staphylococcal hip and knee PJI patients, regardless of surgical strategy. Conclusion: The convenient dosing, safety, and potency of daptomycin make it an attractive antibiotic for staphylococcal PJI. However, these advantages must be weighed against higher costs and rare, but serious side effects.

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“…The cost of treatment of a single episode of PJI can escalate to USD 50,000 or more (9). The increase in antibiotic resistance among hospital-acquired infections like PJI has also increased the risk of failing to successfully treat PJI (15, 16). It is therefore clear that PJI presents a major challenge from both a health-care and economic perspective (17).…”

Section: Introductionmentioning

confidence: 99%

The Effects of Vancomycin on the Viability and Osteogenic Potential of Bone-derived Mesenchymal Stem Cells

Booysen

Gijsen

Deane

et al. 2018

Preprint

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Antibiotic resistance in early periprosthetic joint infection

Cited by 46 publications

References 43 publications

Bacteria antibiotic resistance: New challenges and opportunities for implant‐associated orthopedic infections

Bacteria antibiotic resistance: New challenges and opportunities for implant‐associated orthopedic infections

Assessing the Role of Daptomycin as Antibiotic Therapy for Staphylococcal Prosthetic Joint Infection

The Effects of Vancomycin on the Viability and Osteogenic Potential of Bone-derived Mesenchymal Stem Cells

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