Antibiotic Resistance Increases Evolvability and Maximizes Opportunities Across Fitness Landscapes

Spagnolo, Fabrizio; Dykhuizen, Daniel E.

doi:10.1101/750729

Cited by 2 publications

(2 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We have learned that reversion to sensitivity is neither an immediate nor necessary outcome of selection simply because a resistant pathogen is no longer in an antibiotic-laden environment ( 24 , 25 ). The reasons for this relate to the lasting impact of antibiotic treatment upon microbes as well as changes at the genetic level that reconfigure the fitness landscape for resistant populations and make reversion less likely ( 26 – 28 ). In essence, the presence of clinical concentrations of antibiotics more strongly selects for resistance than the absence of antibiotics selects for reversion to antibiotic sensitivity.…”

Section: Rise Of Resistancementioning

confidence: 99%

Why Do Antibiotics Exist?

Spagnolo

Trujillo

Dennehy

2021

mBio

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Rise Of Resistancementioning

confidence: 99%

Why Do Antibiotics Exist?

Spagnolo

Trujillo

Dennehy

2021

mBio

Self Cite

View full text Add to dashboard Cite

show abstract

“…In addition to rpoA / B , studies in other bacteria highlight rpsD and rpsE as potentially playing a role in the compensation of STR resistance costs [ 104 , 106 , 107 ]. Typically, the amino acid mutations in rpsD and rpsE were shown to occur after stress, affecting translation efficiency [ 108 ]. Interestingly, it was predicted in silico that rpsE can interact with rpoB [ 109 ].…”

Section: Streptomycin-resistant Mutations and Fitness Costsmentioning

confidence: 99%

The Neglected Contribution of Streptomycin to the Tuberculosis Drug Resistance Problem

Rocha

Viveiros²,

Saraiva

et al. 2021

Genes

View full text Add to dashboard Cite

The airborne pathogen Mycobacterium tuberculosis is responsible for a present major public health problem worsened by the emergence of drug resistance. M. tuberculosis has acquired and developed streptomycin (STR) resistance mechanisms that have been maintained and transmitted in the population over the last decades. Indeed, STR resistant mutations are frequently identified across the main M. tuberculosis lineages that cause tuberculosis outbreaks worldwide. The spread of STR resistance is likely related to the low impact of the most frequent underlying mutations on the fitness of the bacteria. The withdrawal of STR from the first-line treatment of tuberculosis potentially lowered the importance of studying STR resistance. However, the prevalence of STR resistance remains very high, could be underestimated by current genotypic methods, and was found in outbreaks of multi-drug (MDR) and extensively drug (XDR) strains in different geographic regions. Therefore, the contribution of STR resistance to the problem of tuberculosis drug resistance should not be neglected. Here, we review the impact of STR resistance and detail well-known and novel candidate STR resistance mechanisms, genes, and mutations. In addition, we aim to provide insights into the possible role of STR resistance in the development of multi-drug resistant tuberculosis.

show abstract

Antibiotic Resistance Increases Evolvability and Maximizes Opportunities Across Fitness Landscapes

Abstract: 4Antibiotic resistance continues to grow as a public health problem. One of the reasons for this 1 5 9 0

Cited by 2 publications

References 47 publications

Why Do Antibiotics Exist?

Why Do Antibiotics Exist?

The Neglected Contribution of Streptomycin to the Tuberculosis Drug Resistance Problem

Contact Info

Product

Resources

About