Antibiotic‐resistant <i>Propionibacterium acnes</i> among acne patients in a regional skin centre in Hong Kong

Luk, N. M.; Hui, Mamie; Lee, H.-C.S.; Fu, Liu; Liu, Z.H.; Lam, L.; Eastel, M.; Chan, Yung; Tang, Long; Cheng, Tim; SIu, Fialkovskiĭ; Ng, S.C.; Lai, Yuping; Ho, King Man

doi:10.1111/j.1468-3083.2011.04351.x

Cited by 68 publications

(83 citation statements)

References 24 publications

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“…As many investigators have pointed out [12,18,19], acne treatment in Japan is peculiar in that the use of benzoyl peroxide, isotretinoin and azelaic acid is restricted. In spite of the high frequency of antibiotic use, however, a low rate of antibiotic-resistant strains (4-20.9%) has been reported in some Japanese studies [20,21,22].…”

Section: Discussionmentioning

confidence: 99%

Analysis of Facial Skin-Resident Microbiota in Japanese Acne Patients

et al. 2013

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Objectives: We investigated the facial skin microbiota of Japanese acne patients. Methods: Skin swab samples were obtained from 100 acne patients and 28 healthy controls to evaluate Propionibacterium and Staphylococcus spp. using a culture method. Malassezia spp. were evaluated using a nonculture method. Antibiotic resistance of Propionibacterium spp. was also examined. Results: Acne patients and controls did not show significant differences in Propionibacterium and Staphylococcus spp. populations. However, the number of Malassezia globosa from patients was greater than that from controls. Moreover, the number of Propionibacterium spp. from patients carrying antibiotic-resistant strains was significantly greater than that from patients not carrying them. Conclusions: The present study characterized the facial skin microbiota of Japanese acne patients, suggesting a correlation between acne and quantitative differences in Malassezia microbiota. It was also found that the antibiotic resistance of Propionibacterium spp. may affect its abundance in the skin.

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Section: Discussionmentioning

confidence: 99%

Analysis of Facial Skin-Resident Microbiota in Japanese Acne Patients

et al. 2013

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“…There is widespread resistance in P. acnes due to overuse of topical and systemic antibiotics for treatment of acne vulgaris [3,[8][9][10][11][12][13][14][15][16], as shown in Table 4. Various studies have used different interpretative criteria to estimate the resistance among P. acne strains to different anti-acne drugs.…”

Section: Discussionmentioning

confidence: 99%

In vitro antimicrobial susceptibility patterns of Propionibacterium acnes isolated from patients with acne vulgaris

Biswal

Gaind

Kumar

et al. 2016

J Infect Dev Ctries

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Introduction: Propionibacterium acnes has been implicated in the development of acne vulgaris. Rampant use of topical and systemic antibiotics for acne vulgaris has led to resistance due to selective pressure. This study aimed to determine antibiotic resistance of P. acnes. Methodology: A total of 102 samples were collected from acne lesions and cultured onto sheep's blood agar and brain-heart infusion agar supplemented with 5 g/L glucose and 2 mg/L furazolidone) (BHIg) under aerobic and anaerobic conditions. Species identification was done by conventional methods and the VITEK2 Compact system. The isolates were tested for penicillin, erythromycin, clindamycin, ciprofloxacin, nadifloxacin, and tetracycline by E-test, and minimum inhibitory concentration (MIC) of minocycline was determined by agar dilution on BHIg. MIC results were interpreted as per EUCAST (European Committee on Antimicrobial Susceptibility Testing) and CLSI (Clinical Laboratory Standards Institute) guidelines. Results: P. acnes was the most common anaerobe (66%) isolated. Resistance rates using EUCAST and CLSI breakpoints were 10.6% and 6.1%, 7.6% and 0%, 7.8% and 0% for erythromycin, clindamycin, and minocycline, respectively. Tetracycline resistance was observed in 9.2% isolates irrespective of the interpretative criteria used. MIC50 and MIC90 values for nadifloxacin (0.25 and 1 µg/mL) were found to be twofold lower than those for ciprofloxacin (0.5 and 1 µg/mL). Similarly, MIC50 and MIC90 values for minocycline (0.125 and 0.5 µg/mL) were also two-to threefold lower than those for tetracycline (0.38 and 1 µg/mL). Conclusions: To the best of our knowledge, this is the first study focusing on P. acnes resistance from India.

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“…Propionibacterium acnes resistance to erythromycin was described as early as 1972 (1). Since then widespread resistance among P. acnes to macrolides, lincosamines, and tetracyclines has been reported from many countries worldwide (1)(2)(3)(4)(5)(6)(7)(8)(9)(10). Resistance in P. acnes to relevant antibiotics is due mainly to a few point mutations in genes encoding ribosomal RNAs.…”

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confidence: 99%

Clonality and Anatomic Distribution on the Skin of Antibiotic Resistant and Sensitive Propionibacterium acnes

Lomholt¹,

Kilian²

2014

Acta Derm Venerol

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Increasing antibiotic resistance in the population of Propionibacterium acnes is a major concern. Our aims were to examine the clonal relationships and anatomical distribution of resistant and sensitive P. acnes. A collection of 350 P. acnes isolates was therefore used to determine the minimum inhibitory concentration of tetracycline, erythro-mycin and clindamycin, multilocus sequence type, and the identity of genetic resistance markers. Two hitherto unknown resistance mutations were detected. Resistant P. acnes mainly belonged to clonal clusters in division I-1a frequently isolated from skin and associated with moderate to severe acne. All high-level tetracycline resistant strains were members of a single clone. Multiple isolates from distinct anatomic areas of surface skin and follicles of 2 acne patients revealed substantial clonal diversity between areas and co-existence of resistant and sensitive clones. Fifty-two percent of Danish acne patients and 43% of controls carried at least one resistant P. acnes strain, resistance to clindamycin being most frequent followed by tetracycline and erythromycin. Resistance to tetracycline was detected exclusively among isolates from acne patients. In conclusion, antibiotic resistance is associated with particular evolutionary clades of P. acnes and a substantial part is due to a single geographically widespread clone (ST3). Individuals carry a strikingly complex population of P. acnes with distinct virulence potential and antibiotic resistance.

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Antibiotic‐resistant Propionibacterium acnes among acne patients in a regional skin centre in Hong Kong

Abstract: Antibiotic-resistant P. acnes is prevalent in Hong Kong. Dermatologists should be more vigilant in prescribing antibiotics for acne patients.

Cited by 68 publications

References 24 publications

Analysis of Facial Skin-Resident Microbiota in Japanese Acne Patients

Analysis of Facial Skin-Resident Microbiota in Japanese Acne Patients

In vitro antimicrobial susceptibility patterns of Propionibacterium acnes isolated from patients with acne vulgaris

Clonality and Anatomic Distribution on the Skin of Antibiotic Resistant and Sensitive Propionibacterium acnes

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