Antibiotic sensitivities of common bacterial pathogens in urinary tract infections at Gondar Hospital, Ethiopia

Moges, Asmamaw; Genetu, Abraham; Mengistu, Gebeyahu Zeleke

doi:10.4314/eamj.v79i3.8893

Cited by 62 publications

(71 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The most predominant for UTIs are gram-negative bacteria, particularly Escherichia coli, which is mainly responsible for the high prevalence (Moges et al, 2002). In those with frequent infections, low-dose antibiotics may be taken as a preventative measure.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Resistance in Uropathogen Isolates from Patients with Urinary Tract Infections

et al. 2015

View full text Add to dashboard Cite

Abstract-Aims:Because of uncontrolled and widespread use of antibiotics, the resistance pattern of uropathogens is changing drastically, specifically in developing countries, such as Bangladesh. The aim of the study was to identify the common Urinary Tract Infection (UTI) causing pathogens in the city of Jessore, Bangladesh and to check the performance of available antibiotics used by those patients. Study Design: Random 100 UTI patients who exhibited general UTI symptoms were included in our cross-sectional study. A medical proforma was prepared to input the information associated with the experiment including symptoms of patient's age, sex, laboratory diagnosis and antimicrobial susceptibility. Place and Duration of Study: Department of Microbiology, University of Science and Technology, Jessore 7408 and Pharmacy Discipline, Life Science School, Khulna University, Khulna 9208, Bangladesh, between June 2013 and July 2014.Methodology:Urine samples from 100 suspicious urinary tract infected patients were collected as described by Thomson and Miller. Bacterial isolates were tested to identify the bacterial species and to evaluate their antimicrobial susceptibility by Kirby-Bauer disk diffusion technique against some common antibiotics. Epidata® computer program 3.1 and SPSS version 16 statistical software used for confidence interval (CI) and P value, which were defined as P value is <0.05 and CI was set at 95% level of significance for all the proportions.Results: Among 100 samples, 74 samples showed positive for cultures adversely responsible for UTIs. About five different species of uropathogenswere identified from 74 cases. Comparative prevalence ofE. coli was detected in 69 of the 100 samples (69%), while Staphylococcus spp was found in 18 samples (18%), Pseudomonas aeruginosa in 8 samples (8%), and Klebsiella pneumoniae in 6 samples (6%), respectively. Comparative antibiotic resistance profile showed that most of the strains were highly resistant to Amoxicillin (85.14%) and Cotrimoxazole (81.08%). On the contrary, the strains showed significant sensitivity to Amikacin (94.59%), Azithromycin (93.24%), Doxycycline (90.54%), and Ceftriaxone (89.18%), respectively showed significant sensitivity. Conclusion: Our results could be helpful to compel rational antibiotic use for UTI. High resistance of uropathogens to antibiotics, such as Amoxicillin and Cotrimoxaxole, has been observed in a significant number of patients in the developing world, such as Bangladesh. Our studies may provoke further investigations into the mechanisms of antibiotic resistance of particular microbes.

show abstract

Section: Introductionmentioning

confidence: 99%

Antimicrobial Resistance in Uropathogen Isolates from Patients with Urinary Tract Infections

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Occurrence of urinary pathogens varies among different age groups, sex, catheterization, hospitalization and previous exposure to antimicrobials 11 . Signs and symptoms of burning sensation during urination, frequent or intense urges to urinate, back or lower abdominal pain, fever or chills 12 , frequently characterize severe UTI.…”

Section: Introductionmentioning

confidence: 99%

Resistant plasmid profile analysis of multidrug resistant <i>Escherichia coli</i> isolated from urinary tract infections in Abeokuta, Nigeria

Akingbade¹,

Balogun²,

Ojo³

et al. 2015

Afr H. Sci.

View full text Add to dashboard Cite

Background: Multi-drug resistant Escherichia coli has become a major threat and cause of many urinary tract infections (UTIs) in Abeokuta, Nigeria. Objectives: This study was carried out to determine the resistant plasmids of multidrug resistant Escherichia coli isolated from (Urinary tract infections)UTIs in Abeokuta. Methods: A total of 120 Escherichia coli isolates were obtained from urine samples collected from patients attending inpatient and outpatient clinics presenting UTI; with their biodata. Antibiotics susceptibility was performed and multi-drug resistant isolates were selected for plasmid profiling. Plasmids were extracted by the alkaline lysis method, electrophoresed on 0.8% agarose gel and profiled using a gel-photo documentation system gel. Results: Escherichia coli isolates obtained shows high resistance to cloxacillin (92.5%), amoxicillin (90.8%), ampicillin (90.8%), erythromycin (75.8%), cotrimoxazole (70.0%), streptomycin (70.0%) and tetracycline (68.3%) while 85.8% and 84.2% were susceptible to gentamycin and ceftazidime respectively. Sixteen Escherichia coli strains were observed to be resistant to more than two classes of antibiotics. The resistant plasmid DNA was detectable in 6(37.5%) of the 16 multidrug resistant Escherichia coli having single sized plasmids of the same weight 854bp and were all resistant to erythromycin, cefuroxime, cloxacillin, amoxicillin, ampicillin and cotrimoxazole. Conclusion: This study has highlighted the emergence of multidrug resistant R-plasmids among Escherichia coli causing urinary tract infections in Abeokuta, Nigeria. There is a high level of resistance to many antimicrobials that are frequently used in Abeokuta, Nigeria.

show abstract

“…Aliquots of urine samples were centrifuged at 3000 rpm for 10-15 minutes. Sediment from each sample was used to streak culture media and prepare a wet mount for microscopy (9). The remainder of the urine was tested biochemically using dipsticks impregnated with leucocyte esterase and nitrite tests.The urine dipstick kit used was Medi-Test Combi 9 (Macherey-Nagel, Germany).…”

Section: Methodsmentioning

confidence: 99%

“…The most common pathogen involved in bacteriuria is Escherichia coli accounting for 60 to 90% of infections in women. Other bacteria involved include Klebsiella pneumoniae, Proteus mirabilis, and Pseudomonas aeruginosa (9). Gram-positive organisms like Staphylococcus saprophyticus also cause bacteriuria (10).…”

Section: Introductionmentioning

confidence: 99%

Bacteriuria in Pregnant and Non Pregnant Women in Benghazi Acomparative Study

Almehdawi¹,

Ali²,

Ismail³

2017

IOSRJPBS

View full text Add to dashboard Cite

Antibiotic sensitivities of common bacterial pathogens in urinary tract infections at Gondar Hospital, Ethiopia

Cited by 62 publications

References 0 publications

Antimicrobial Resistance in Uropathogen Isolates from Patients with Urinary Tract Infections

Antimicrobial Resistance in Uropathogen Isolates from Patients with Urinary Tract Infections

Resistant plasmid profile analysis of multidrug resistant <i>Escherichia coli</i> isolated from urinary tract infections in Abeokuta, Nigeria

Bacteriuria in Pregnant and Non Pregnant Women in Benghazi Acomparative Study

Contact Info

Product

Resources

About