Antibiotic Sensitivity of Clinical Isolates at Outpatient Unitin Tver, Russia: A Comparatives

Abstract

Background Discovery of antibiotics opened a new era in the treatment of bacterial diseases. However, the microorganisms are able to adapt and resist the effects of the drugs. Objective Our study is aimed to investigate the sensitivity of clinical specimens to antibiotics. Methods Clinical samples of 280 case record forms were collected at departments of surgery, urology and otorhinolaryngology in an ambulatory clinic (Tver, Russia) during 2019. The results of microbiologically assessed isolates from pharynx, nose, ears, eyes, wounds, sputum and urine underwent statistical analysis. Results The outcomes confirmed a general trend of reduced susceptibility of bacteria to antibiotics. The worst result was shown by protected Amoxicillin; practically no microorganisms were sensitive to it. Protected Cephalosporins Cephalosporins of IV generation and Imipenem were among the best, although not highly sensitive to all the pathogens. Conclusion United efforts of all states are required to combat the growing antibiotic resistance. It is necessary to adhere to strict regulations on dispense of antibiotics in pharmacies and the use of antibiotics therapy

Cephalosporin Antibiotic Resistance

“…Our findings were often consistent with other studies on antimicrobial resistance. However, some of them provided new data on the topic, the individual principles of therapy in different treatment and prevention settings, and the impact of the health care system on knowledge, attitudes and patterns of antibiotic use [3,4,7,8].…”

Antibiotic Resistance of E. Coli in Clinical Practice

“…If specific virulence factors are acquired, opportunistic E. coli can form nosological strains which determine a wide range of diseases. In addition to typical intestinal pathologies, extraintestinal forms of the pathogen cause infections of other localizations, among which uropathogenic and meningitis-associated strains are the most common [6,7,8]. E. coli are widespread.…”