Antibiotic susceptibilities of recent isolates of<i>Mycopasma bovis</i>in Belgium

Thomas, Anne; Nicolás, Cifuentes-Muñoz; Dizier, Isabelle; Mainil, Jacques; Lindén, Annick

doi:10.1136/vr.153.14.428

Cited by 45 publications

(49 citation statements)

References 27 publications

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“…If this occurs, then M. bovis infection might persist because many strains are resistant to the antibiotics commonly used to treat pneumonia in feedlot cattle 4,31,33 and because the variability of the immunodominant surface lipoproteins could allow evasion of the immune response. 15 Thus, although M. bovis commonly colonizes normal bovine lungs without ill effect, it might be able to proliferate and express virulence genes within the lesions of fibrinosuppurative bronchopneumonia, leading to a self-perpetuating, antibiotic-resistant, chronic disease.…”

Section: Discussionmentioning

confidence: 99%

“…1,2,7,8,23,25,28 Many strains of M. bovis are resistant to the antibiotics that are commonly used in feedlots, consistent with observations that natural disease often persists despite antibiotic therapy. 4,31,33 Mycoplasma bovis has the ability to undergo antigenic variation by phenotypic alteration of the immunodominant surface lipoproteins 5,15,26 and modulates the host immune response. 11,35,37,38 In addition, M. bovis can adhere to, invade, and survive in epithelial and inflammatory cells.…”

Section: Introductionmentioning

confidence: 99%

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Naturally Occurring Mycoplasma Bovis—Associated Pneumonia and Polyarthritis in Feedlot Beef Calves

Gagea¹,

et al. 2006

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Abstract. Mycoplasma bovis is perceived as an emerging cause of mortality in feedlot beef cattle. This study examined the lesions and infectious agents in naturally occurring M. bovis-associated bronchopneumonia and arthritis and the relationship of this condition with bovine viral diarrhea virus (BVDV) infection. Standardized pathologic, immunohistochemical, and microbiologic investigations were conducted on 99 calves that died or were euthanized within 60 days after arrival in 72 feedlots. Cranioventral bronchopneumonia with multiple foci of caseous necrosis was identified in 54 of 99 calves, including 30 with concurrent fibrinosuppurative bronchopneumonia typical of pneumonic pasteurellosis. Mycoplasma bovis was consistently identified in these lesions by culture and immunohistochemistry, but also commonly in healthy lungs and those with pneumonia of other causes. Focal lesions of coagulation necrosis, typical of pneumonic pasteurellosis, were often infected with both Mannheimia haemolytica and M. bovis. Arthritis was present in 25 of 54 (46%) calves with M. bovis pneumonia, and all calves with arthritis had pneumonia. BVDV infection was more common in calves with lesions of bacterial pneumonia than in those dying of other causes, but BVDV infection was not more common in calves with caseonecrotic bronchopneumonia than those with fibrinosuppurative bronchopneumonia. Retrospective analysis identified cases of M. bovis pneumonia in the early 1980s that had milder lesions than the current cases. The findings suggest that, in at least some calves, M. bovis induces caseonecrotic bronchopneumonia within the lesions of pneumonic pasteurellosis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Naturally Occurring Mycoplasma Bovis—Associated Pneumonia and Polyarthritis in Feedlot Beef Calves

Gagea¹,

et al. 2006

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“…Marbofloxacin is a third generation of fluoroquinolone with broad spectrum antimicrobial activity against some grampositive, most gram-negative organisms and Mycoplasma [2][3][4] with a relatively low concentration [5,6]. It prevents the bacterial DNA replication and synthesis via inhibition of the A subunit of the bacterial DNA gyrase.…”

Section: Discussionmentioning

confidence: 99%

“…Marbofloxacin is considered the third generation fluoroquinolone with broad spectrum activity against some gram-positive, gram-negative organisms and Mycoplasma [2][3][4]. It has bactericidal action by a concentration -dependent mechanism [5].…”

Section: Introductionmentioning

confidence: 99%

Determination of Marbofloxacin residues in Rabbit Tissues by HPLC

Aziz

El‐Nabtity

Barawy³

et al. 2017

Zagazig Veterinary Journal

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The present study was designed to evaluate marbofloxacin residues in different rabbit tissues after multiple intramuscular administrations. For that purpose, rabbits were divided into two groups; the first group (n=21) administered 2mg/kg marbofloxacin for five successive days, while the second group (n=3) were untreated and served as controls. th and 21 st day after the last dose post administration of the drug. Liver, kidneys, pectoral muscle and thigh muscles, spleen, heart, blood and lung from each rabbit were taken, extracted and marbofloxacin residues were analyzed using high-performance liquid chromatographic method with ultraviolet detection. Results indicated a widespread distribution of marbofloxacin in the most tested tissues. It remained within detectable level till the 5 th day in liver and serum while it continues till the 7 th in kidneys day following the last dose. Therefore, muscles of rabbits treated with marbofloxacin could be consumed safely following the 1 st day post treatment, while liver and kidneys could be consumed safely in the 3 rd day after treatment without any hazards on consumers as the residual level below the recommended MRL (150µg/kg).

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“…5,6,13 Commercial vaccines preventing the infection are not presently available, with the exception of recently approved, custom-designed, inactivated vaccines for use in North America. Increasing numbers of M. bovis strains are developing resistance to antibiotics, 18 and knowledge of pathogenesis and persistence of M. bovis, especially in the respiratory tract, is still insufficient.…”

mentioning

confidence: 99%

In Situ Hybridization for the Detection of Mycoplasma Bovis in Paraffin-Embedded Lung Tissue from Experimentally Infected Calves

Jacobsen¹,

Hermeyer²,

Jechlinger

et al. 2010

J VET Diagn Invest

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Abstract. Mycoplasma bovis DNA was detected in lung tissue of experimentally infected calves by in situ hybridization (ISH) with a nonradioactive, digoxigenin-labeled DNA probe. The 171-base pair DNA probe targeting part of the gene of the major immunodominant variable surface protein A, which is conserved among all vsp genes, was generated by polymerase chain reaction. Four calves between 57 and 63 days old were inoculated intratracheally with 30 ml of a suspension of M. bovis strain 1067 containing 7 3 10 4 colony forming units per milliliter. Two calves inoculated with 30 ml of sterile medium served as control animals. The calves were euthanized and then examined 21 days after inoculation. The ISH method developed in the current study was suitable for the detection of M. bovis DNA in formalin-fixed, paraffin-embedded lung tissue and may be a valuable tool for diagnostic purposes and for further investigating the pathogenesis of M. bovis infection.

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Antibiotic susceptibilities of recent isolates ofMycopasma bovisin Belgium

Cited by 45 publications

References 27 publications

Naturally Occurring Mycoplasma Bovis—Associated Pneumonia and Polyarthritis in Feedlot Beef Calves

Naturally Occurring Mycoplasma Bovis—Associated Pneumonia and Polyarthritis in Feedlot Beef Calves

Determination of Marbofloxacin residues in Rabbit Tissues by HPLC

In Situ Hybridization for the Detection of Mycoplasma Bovis in Paraffin-Embedded Lung Tissue from Experimentally Infected Calves

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