Antibiotic Susceptibility of Escherichia coli Strains Isolated in Community Acquired Urinary Tract Infections

Gözüküçük, Ramazan; Çakıroğlu, Basri; Nas, Yunus

doi:10.5152/jarem.2012.24

Cited by 3 publications

(4 citation statements)

References 4 publications

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“…In a study conducted by Gozukucuk et al in Istanbul,191 E. coli strains were isolated and the resistance rates were found to be 40% in trimethoprim-sulfamethoxazole, 19.8% in ciprofloxacin, 19.2% in ceftriaxonde and 12.4% in nitrofurantoin (14). In our study, nitrofurantoin resistance with 5.8% was lower than this study, whereas, Ciprofloxacin resistance was higher with 34.1%.…”

Section: Discussioncontrasting

confidence: 64%

Türkiye'nin Doğusunda Üçüncü Basamak Bir Hastanede İdrar Örneklerinden İzole Edilen Escherichia coli Suşlarının Antibiyotiklere Duyarlılıkları

Erdoğan¹,

Akbulut²

2021

Konuralp Tıp Dergisi

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Objective: Escherichia coli is the most common cause of urinary tract infections. The increase and spread of resistance to antibiotics is a serious problem in our country as well as in the world. The aim of this study was to determine the antimicrobial susceptibility profiles of E. coli strains that cause urinary tract infection. Methods: The antibiotic susceptibilities of 1850 E. coli strains isolated from urine samples of patients who applied to Urology service and outpatient clinics of Malatya Education and Research Hospital, which is a tertiary care hospital in eastern part of Turkey, over the 3 years between July 2016 and July 2019, were evaluated retrospectively from computer records using the Vitek 2.0 Compact automated system (BioMérieux, France). Antibiogram results were classified as susceptible, moderately susceptible and resistant. Result: Of the total 1850 samples, 1300 (70.3%) were female and 550 (29.7%) were male, with a mean age of 52 (18-104) years. 73 (3.9%) of the patients were inpatients and 1777 were outpatients. All the isolated E. coli strains were found to be susceptible to ampicillin 39.2%, amoxicillin-clavulanic acid 67.9%, piperacillin-tazobactam 80.8%, cefuroxime 67.1%, cefotaxime 68.8%, cefixime 67.7%, ceftazidime 71.2%, cefepime 73.9%, ertapeneme 97.9%, imipeneme 99.5%, meropeneme 99.7%, amikacin 89.7%, gentamicin 78.4%, norfloxacine 65.8%, ciprofloxacine 65.9%, nitrofurantoin 94.2% and fosfomycin 96.5%. Resistance rates were higher in inpatients as compared to outpatients. Antibiotic susceptibilities were found to be decreased in different age ranges with increasing age. Conclusion:When selecting the antimicrobial treatment in community-acquired urinary tract infections, considering the antimicrobial resistance data in the region, the choice of cost-effective treatment with high patient compliance and low resistance rates will increase treatment success. It is thought that antibiotic treatment should be determined according to the results of culture antibiograms, especially in nosocomial infections due to high resistance rates.

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Section: Discussioncontrasting

confidence: 64%

Türkiye'nin Doğusunda Üçüncü Basamak Bir Hastanede İdrar Örneklerinden İzole Edilen Escherichia coli Suşlarının Antibiyotiklere Duyarlılıkları

Erdoğan¹,

Akbulut²

2021

Konuralp Tıp Dergisi

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“…reported that positive urine culture was detected in 348 of 1493 patients visiting the outpatient clinic due to UTI and E. coli was the main causative agent in 54.8% of the cases. [ 19 ] According to the urine culture and antibiogram reports, they detected sensitivity rates as; 36.3% for ampicillin, 80.2% for ciprofloxacin, and 87.6% for nitrofurantoin. [ 19 ] In a retrospective study, Pekdemir et al .…”

Section: Discussionmentioning

confidence: 99%

“…[ 19 ] According to the urine culture and antibiogram reports, they detected sensitivity rates as; 36.3% for ampicillin, 80.2% for ciprofloxacin, and 87.6% for nitrofurantoin. [ 19 ] In a retrospective study, Pekdemir et al . detected positive urine culture in 90 of 257 patients admitted to the ED, and they identified E. coli as the most common agent (57.8%), and antibiotic susceptibility to E. coli was reported as; 51.9% for ciprofloxacin, 34.6% for ampicillin, and 85.3% for nitrofurantoin.…”

Section: Discussionmentioning

confidence: 99%

Which patient should start empirical antibiotic treatment in urinary tract infection in emergency departments?

et al. 2020

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OBJECTIVES: This study aims to determine the factors that would lead the doctors in EDs to a more the accurate diagnosis of urinary tract infection (UTI) and the correct initiation of empirical antibiotherapy in the emergency room and reduce the use of unnecessary antibiotherapy. METHODS: This study is a prospective observational study from a single-center, investigating patients with an age of 18 years and older who presented to the emergency department (ED) with the symptoms of UTI between January and May 2018. The guiding parameters to establish a UTI diagnosis and start an empirical antibiotherapy were investigated between the negative (Group 1) and positive (>10 3 colonies) (Group 2) groups, as a result of urine culture in terms of urine culture. RESULTS: Our study included a total of 108 patients (59 women and 49 men). The average age was 47.11 ± 14.97. Age and gender were similar among the groups and not a discriminating factor in the diagnosis of UTI. High Charlson Comorbidity Index score, history of chronic kidney failure and cerebrovascular disease, leukocyte esterase, nitrite positivity, and leukocyte cluster presence were higher in Group 2. We suggest that these parameters might be predictive values to detect bacterial growth in urine culture. Empirical antibiotherapy was started in 48.4% of the patients in Group 1 and 95.7% of the patients in Group 2. CONCLUSIONS: In EDs, admission complaints of the patients and physical examination findings do not always result in the diagnosis of UTI. Our study showed that UTI diagnosis could be made more accurately using leukocyte esterase, nitrite positivity, the presence of leukocyte clusters, and the Charlson Comorbidity Index score. We also suggest that regional antibiotic resistance should be considered before starting empirical antibiotherapy.

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“…In our country, TMP-SXT resistance varies from 20% to 60% for E. coli strains isolated from community-acquired urinary tract infections (Table 4) [8,9,[13][14][15][16]. Because of the high TMP-SXT resistance, it seems that TMP-SXT has not been included in the prescriptions arranged by our polyclinics in accordance with the recommendations of guidelines.…”

Section: Discussionmentioning

confidence: 99%

Resistance patterns of gram negative bacteria in urinary tract infections and efficacy of empirical treatment in noncomplicated cases: Retrospective cohort study of 2180 women

Varışlı¹,

Hazırolan²,

Çelikbaş³

et al. 2018

Journal of Surgery and Medicine

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Aim: Community and hospital acquired urinary tract infections (UTI) are the most common bacterial infections in all age groups. In this study, the women diagnosed UTI, which complicated and uncomplicated, were referred to outpatient clinics between 2011 and 2015 were selected. The suitability of empirical antimicrobial therapy prescribed with resistance patterns of Gram negative bacteria isolated from these patients was investigated. Methods: UTI complaining and urine culture ≥10⁵ cfu / ml of bacteria that women aged 18-65 were comprised the study group. HIS (Hospital Information System Software) was scanned for these patients and uncomplicated and complicated UTI distinction was made according to the criteria set by Infectious Diseases Society of America (IDSA, 2016 Resistance patterns and empirical treatment in urinary tract infection P a g e / S a y f a | 100

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Antibiotic Susceptibility of Escherichia coli Strains Isolated in Community Acquired Urinary Tract Infections

Cited by 3 publications

References 4 publications

Türkiye'nin Doğusunda Üçüncü Basamak Bir Hastanede İdrar Örneklerinden İzole Edilen Escherichia coli Suşlarının Antibiyotiklere Duyarlılıkları

Türkiye'nin Doğusunda Üçüncü Basamak Bir Hastanede İdrar Örneklerinden İzole Edilen Escherichia coli Suşlarının Antibiyotiklere Duyarlılıkları

Which patient should start empirical antibiotic treatment in urinary tract infection in emergency departments?

Resistance patterns of gram negative bacteria in urinary tract infections and efficacy of empirical treatment in noncomplicated cases: Retrospective cohort study of 2180 women

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