Antibiotic susceptibility profiles of anaerobic pathogens in The Netherlands

Veloo, Alida; Winkelhoff, van Arie

doi:10.1016/j.anaerobe.2014.08.011

Cited by 59 publications

(22 citation statements)

References 19 publications

(18 reference statements)

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“…Fusobacteriae remain highly susceptible to beta-lactams. Studies on susceptibility patterns have shown no increase in amoxicillin-resistant Fusobacteriae over the past decade [22–24]. They are unlikely to be accompanied by highly resistant co-pathogens in polymicrobial infection of oral or periodontal origin.…”

Section: Discussionmentioning

confidence: 99%

Fusobacterial liver abscess: a case report and review of the literature

Jayasimhan

Huggan

2017

BMC Infect Dis

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BackgroundFusobacteriae are facultative anaerobic gram-negative bacilli which cause a range of invasive infections, amongst which pyogenic liver abscesses are rare. We describe a case of Fusobacterium nucleatum liver abscess and review the relevant literature.Case presentationA 51-year-old lady presented with a 4-day history of abdominal pain, diarrhoea, fever, rigors, and lethargy. Imaging revealed an abscess which was drained. Cultures of the blood and abscess aspirate grew Fusobacterium nucleatum and Prevotella pleuritidis respectively. She achieved full recovery following treatment.A MEDLINE search was undertaken using free-text and Medical Subject Headings (MeSH), keywords “Fusobacterium” and “Liver abscess”. Non-English language reports and cases without confirmed growth of Fusobacterium species were excluded. Additional cases were identified by surveying the references of each report and by using the same keywords in a web-based search.Forty-eight cases were identified, 41 in men. The median age was 42.5, with an interquartile range of 33. F. nucleatum and F. necrophorum were in involved in 22 cases each, and 4 cases were not further speciated. Among cases of F. nucleatum liver abscess, nine were attributed to periodontal disease, four to lower gastrointestinal tract disease, one to Lemierre’s Syndrome, and eight were considered cryptogenic. All patients treated made a full recovery. Antimicrobial treatment duration ranged from 2 weeks to 6 months with a median of 6 weeks.ConclusionFusobacterium nucleatum is an uncommon cause of liver abscess generally associated with good clinical outcomes with contemporary medical and surgical care.

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Section: Discussionmentioning

confidence: 99%

Fusobacterial liver abscess: a case report and review of the literature

Jayasimhan

Huggan

2017

BMC Infect Dis

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“…(8-31%). However, in some countries with antimicrobial stewardship it remains active against Fusobacterial species [105]. The carbapenems ertapenem and doripenem are generally effective against Fusobacterium spp.…”

Section: Antimicrobial Susceptibility Of Fusobacterial Speciesmentioning

confidence: 99%

Fusobacterial head and neck infections in children

Brook

2015

International Journal of Pediatric Otorhinolaryngology

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“…As among aerobic bacteria, the antibiotic resistance in anaerobic bacteria is increasing. Decades ago the resistance to clindamycin among the Bacteroides group isolates was 6% [2] compared with 21% in 2015 [3]. Resistance genes among anaerobic bacteria can be exchanged by horizontal gene transfer.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of antimicrobial resistance genes in Bacteroides spp. and Prevotella spp. Dutch clinical isolates

Veloo

Baas

Haan

et al. 2019

Clinical Microbiology and Infection

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a b s t r a c tObjectives: The prevalence of resistance genes in two important anaerobic genera, Bacteroides and Prevotella, was assessed by applying PCR specifically directed to genes of interest. Methods: A total of 101 Bacteroides spp. and 99 Prevotella spp. human clinical isolates were identified using MALDI-TOF MS. The presence of the resistance genes cfxA, cepA, cfiA, tetQ, ermF and nim, was assessed. Prevalence of resistance genes was compared with the phenotypic resistance against amoxicillin, clindamycin, meropenem and metronidazole. Results: Even though the majority of the Bacteroides isolates (95.0%) showed resistance towards amoxicillin, only 52/101 of the isolates harboured one of the resistance genes, accounting for this resistance. Within the genus Prevotella the presence of cfxA (50/99) almost perfectly matched the amoxicillin resistance (48/99). No difference in prevalence of the ermF gene (16/101 and 9/99) and clindamycin resistance (16/101 and 10/99) was observed within Bacteroides and Prevotella, respectively. Two isolates of Prevotella were resistant to metronidazole. One harboured the nim gene. One metronidazolesusceptible isolate of Bacteroides harboured a nim gene. Within the Bacteroides and Prevotella genera, 6/101 strains and 5/99 isolates harboured three different resistance genes, respectively, among them tetQ. TetQ is often located on a conjugative transposon, increasing the chance of horizontal gene transfer between isolates.Conclusions: An unknown mechanism in Bacteroides non-fragilis isolates causes resistance to b-lactam antibiotics. The fact that the prevalence of the tetQ gene among Prevotella is increasing and the existence of isolates harbouring three resistance genes are worrisome developments. A.C.M. Veloo, Clin Microbiol Infect 2019;25:1156

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Antibiotic susceptibility profiles of anaerobic pathogens in The Netherlands

Cited by 59 publications

References 19 publications

Fusobacterial liver abscess: a case report and review of the literature

Fusobacterial liver abscess: a case report and review of the literature

Fusobacterial head and neck infections in children

Prevalence of antimicrobial resistance genes in Bacteroides spp. and Prevotella spp. Dutch clinical isolates

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