Antibiotic therapy for diabetic foot infections in a tertiary care hospital in Jakarta, Indonesia

Radji, Maksum; Putri, Corry Shirleyana; Fauziyah, Siti

doi:10.1016/j.dsx.2014.09.006

Cited by 27 publications

(26 citation statements)

References 20 publications

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“…; Radji et al. ; Yusuf et al. ) designs, which investigated the assessment, management and risk factors for diabetes.…”

Section: Resultsmentioning

confidence: 99%

“…Another more specific role of the pharmacist is in the prevention of diabetic foot infections (Radji et al. ). Two studies found that pharmacists advocated to extend their role to include assessment, patient education, treatment and monitoring of people with diabetes (Wibowo et al.…”

Section: Resultsmentioning

confidence: 99%

“…The literature has suggested that both intradisciplinary and interdisciplinary working relationships need to be maintained and improved (Radji et al. ; Wibowo et al. ).…”

Section: Discussionmentioning

confidence: 99%

“…Only two papers suggested that working collaboratively to provide diabetes care should be maintained and improved (Radji et al. ; Wibowo et al. ).…”

Section: Implications For Education Nursing Practice Health Policy mentioning

confidence: 99%

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The profile of diabetes healthcare professionals in Indonesia: a scoping review

Ligita

Wicking

Harvey

et al. 2018

International Nursing Review

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“…; Radji et al. ; Yusuf et al. ) designs, which investigated the assessment, management and risk factors for diabetes.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…The literature has suggested that both intradisciplinary and interdisciplinary working relationships need to be maintained and improved (Radji et al. ; Wibowo et al. ).…”

Section: Discussionmentioning

confidence: 99%

“…Only two papers suggested that working collaboratively to provide diabetes care should be maintained and improved (Radji et al. ; Wibowo et al. ).…”

Section: Implications For Education Nursing Practice Health Policy mentioning

confidence: 99%

See 2 more Smart Citations

The profile of diabetes healthcare professionals in Indonesia: a scoping review

Ligita

Wicking

Harvey

et al. 2018

International Nursing Review

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“…In resistant isolates, amikacin was dominantly more cost-effective when compared to meropenem and imipenem [6]. As per Canadian study conducted by Chow et al, showed clindamycin dominated other drugs such as cephalexin, cloxacillin, levofloxacin, and amoxicillin+clavulanate with the lowest CER in the treatment of DFT [12]. Radji et al conducted a study in Indonesia found that the most common infecting microorganisms on pus culture to be [13].…”

Section: Discussionmentioning

confidence: 99%

Appropriate Empirical Management of Microbial Infections in a Tertiary Care Hospital: A Cost- Effectiveness Approach.

N¹,

Simon²,

Tomy³

et al. 2018

Asian J Pharm Clin Res

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Objective: Antibiotics are mostly prescribed empirically to decrease health-care costs. This has led to the misuse of antibiotics thereby making them inefficient in the treatment of infections. The aim of this study was to determine the appropriate, cost-effective drug for the empirical therapy in microbial infections.Methods: A prospective observational study was conducted for a period of 6 months. Cost-effectiveness ratio (CER) of these antibiotics prescribed was calculated to determine the cost-effective drugs for the common microorganisms and common infections.Results: In a population of 205 patients, 54.6% were treated based on antibiotic sensitivity pattern whereas 45.3% were treated empirically. In known microbial infections, the prevailing microorganism was extended-spectrum beta-lactamase (ESBL) producing Escherichia-coli (14.3%), Staphylococcus aureus (10.6%), Pseudomonas aeruginosa (9.8%), Klebsiella pneumonia (9.8%), and K. pneumoniae ESBL (6.81%). Based on the CER, the most cost-effective drugs for these organisms were found to be ciprofloxacin, clindamycin, ofloxacin, levofloxacin, and amikacin, respectively. In unknown microbial infection (empirical treatment), Diabetic Foot Infection (DFT) (25.8%), respiratory tract infection (RTI) (23.6%), and urinary tract infection (UTI) (16.1%) were the most common infections. The most cost-effective drugs for these infections were clindamycin, levofloxacin, and azithromycin, respectively. The predominant microorganism in DFT was found to be S. aureus (71%), in UTI was found to be E. coli ESBL (52%), and in RTI were found to be P. aeruginosa (42.4%) and K. pneumonia (32.3%). Conclusion:Appropriate empirical antibiotic treatment is associated with a lower medical cost and a better success rate in patients with microbial infections.

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