Antibiotic Use in Children Is Associated With Increased Risk of Asthma

Marra, Fawziah; Marra, Carlo; Richardson, Kathryn; Lynd, Larry D.; Kozyrskyj, Anita L.; Patrick, David M.; Bowie, William; FitzGerald, J. Mark

doi:10.1542/peds.2008-1146

Cited by 252 publications

(225 citation statements)

References 19 publications

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“…5,9 The high prescription rate of antibiotics in all age groups in our study is also consistent with other reports. 1,10 In a study performed by Marra et al 10 to investigate the association of antibiotic use to later asthma development, 43.3% of the subjects aged up to 9 years were treated with antibiotics over the course of a year. This percentage is somewhat lower than our finding that 58.27% of Belgian children younger than 8 years were treated with antibiotics.…”

Section: Discussionmentioning

confidence: 99%

Coprescription of Antibiotics and Asthma Drugs in Children

et al. 2011

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WHAT THIS STUDY ADDS:In this study, antibiotic use was found to be 1.9 times more frequent in children who were treated with asthma drugs than those who were not. Among children who received an asthma drug, 35.6% were dispensed an antibiotic on the same day. abstract BACKGROUND: In children, antibiotics as well as asthma drugs are frequently prescribed. We investigated the effects of the codispensing of antibiotics and asthma drugs to children. METHODS:Using a health insurance database, we examined dispensing and codispensing of antibiotics and asthma drugs for the period of a 1 year in 892 841 Belgian children aged Ͻ18 years. RESULTS:For a 1-year period, an antibiotic was dispensed to 44.21% of children: 73.05% aged Ͻ3 years; 49.62% aged 3 to 7 years; and 34.21% aged 8 to Ͻ18 years. An asthma drug was dispensed to 16.04% of children: 44.81% aged Ͻ3 years; 17.90% aged 3 to 7 years; and 7.64% aged 8 to Ͻ18 years. Overall, an antibiotic was dispensed without an asthma drug to 38.62% of children versus with an asthma drug to 73.50% of children (P Ͻ .0001). More frequent dispensing of antibiotics to children who received an asthma drug (odds ratio: 1.90; 95% confidence interval: 1.89 -1.91) occurred in all age categories (P Ͻ .0001). In 35.64% of children with an asthma drug dispensed, an antibiotic was dispensed on the same day. CONCLUSIONS:In all age groups, dispensing of antibiotics is more likely in children who have an asthma drug dispensed in the same year. In all age groups, codispensing of antibiotics and asthma drugs is a common practice. Efforts to decrease antibiotic use in children could be improved by focusing on children who are being treated with asthma drugs.

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Section: Discussionmentioning

confidence: 99%

Coprescription of Antibiotics and Asthma Drugs in Children

et al. 2011

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“…In addition, perinatal use of antibiotics, particularly in premature infants, can interfere with the balance of bacterial phyla and diversity of individual species and makes the newborn much more susceptible to infectious inflammatory diseases (10,11). Long-term follow up on the use of antibiotics during the first year of life has shown an association with an increased incidence of inflammatory bowel disease (12), asthma (13), and increased weight gain leading to adult obesity (14). These studies suggest that optimal initial colonization is critical in the adjustment of the newborn to the extrauterine environment.…”

Section: Initial Colonizationmentioning

confidence: 99%

Breast milk, microbiota, and intestinal immune homeostasis

2014

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“…Antibiotic use during pregnancy and in infants and toddlers has been associated with the development of asthma later in life, [522][523][524] although not all studies have shown this association. 525 Intake of the analgesic, paracetamol (acetaminophen), may be associated with asthma in both children and adults, 526 although exposure during infancy may be confounded by use of paracetamol for respiratory tract infections.…”

Section: Medications and Other Factorsmentioning

confidence: 99%