Antibiotic Utilization in Pediatric Hospitalized Patients – A Single Center Study

Abstract

BACKGROUND:Antibiotics are among the most commonly prescribed drugs in paediatrics. In most cases, antibiotics are started on an empirical basis, without proof of a bacterial infection, either before the start of therapy or afterwards.AIM:The main objective of this study was to analyse the consumption of antibiotics in hospitalised paediatric patients.MATERIAL AND METHODS:This retrospective study investigated the consumption of antimicrobials in defined daily doses (DDDs according to the Anatomical Therapeutical Chemical/DDD index) in Pulmonology, Gastroenterology and Nephrology Departments at Pediatric Clinic of the tertiary hospital. The data on the consumption of antimicrobials were collected for five years by using properly designed form. The consumption was related to days of hospital care.RESULTS:The most utilised antibiotics group in all three departments Pulmonology, Gastroenterology and Nephrology Departments were penicillins. Cephalosporins were mostly used in Pulmonology department. Metronidazole and Chloramphenicol were used in minimal quantities in all three departments.CONCLUSION:This study demonstrates that surveillance programs on antibiotic resistance should be established and accompanied by analyses of drug utilisation data which can aid in the creation of valid cross-national studies on antibiotic usage and resistance, to motivate improvements in prescribing and guideline-directed antibiotic prescribing.

Profil Penggunaan Antibiotik Pada Pasien Pediatri Rujukan Berdasarkan Sistem Defined Daily Dose (DDD)

“…Besarnya penggunaan antibiotik berkaitan erat dengan kejadian resistensi bakteri terhadap antibiotik yang merupakan masalah kesehatan masyarakat dan menjadi perhatian utama di seluruh dunia, hal ini dapat berdampak pada morbiditas dan mortalitas [12]. Antibiotic stewardship (penataan pelayanan antibiotik) sebagai cara untuk mengoptimalkan penggunaan antibiotik agar dapat mencegah perkembangan resistensi dan memperbaiki outcome pasien melalui pembentukan tim Program Pengendalian Resistensi Antimikroba (PPRA) yang telah diterapkan termasuk di RSPAL (Rumah Sakit Pusat Angkatan Laut) Dr. Ramelan, Surabaya.…”