2016
DOI: 10.1136/jclinpath-2016-203808
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Antibiotics for tonsillitis: should the emergency department emulate general practice?

Abstract: CS was not being used in the ED to guide antibiotic prescribing for acute tonsillitis. Antibiotic prescribing was based on clinical judgement. Based on derived CS (<3), 80% of patients were inappropriately prescribed antibiotics, particularly broad-spectrum antibiotics. Further studies need to assess use of CS to guide antibiotic prescription in ED. TSs were commonly performed in the ED but did not either improve diagnosis or guide antibiotic prescription.

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Cited by 10 publications
(9 citation statements)
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“…Unfortunately, the results showed a trend (51%) towards prescribing second-line antibiotics; mainly amoxicillin/clavulanate (a broad-spectrum antibiotic). This trend has been observed in other studies [28,29]. Worldwide, there have been no cases reported of GAS resistant to first-line antibiotics in which broadspectrum antibiotics would have been needed [3].…”
Section: Discussionsupporting
confidence: 73%
“…Unfortunately, the results showed a trend (51%) towards prescribing second-line antibiotics; mainly amoxicillin/clavulanate (a broad-spectrum antibiotic). This trend has been observed in other studies [28,29]. Worldwide, there have been no cases reported of GAS resistant to first-line antibiotics in which broadspectrum antibiotics would have been needed [3].…”
Section: Discussionsupporting
confidence: 73%
“…De plus, les indications retenues à l'époque n'étaient pas toujours fondées (on pouvait par exemple utiliser des préparations de bactériophages réputées traiter certaines infections que l'on sait maintenant causées par le virus herpès [16]. De même, l'utilisation de certaines préparations n'était pas toujours appropriée du fait d'une méconnaissance de l'écologie bactérienne impliquée (ce qui arrive encore également de nos jours avec la prescription d'antibiotiques dans le cadre d'infections non systématiquement bactériennes [17]). Enfin, la forte spécificité des bactériophages est un de leur avantage majeur (respect du microbiote, absence d'acquisition de résistance chez les souches non ciblées) mais constitue en même temps l'un des points les plus contraignants (pour choisir le ou les bactériophages actifs, il demeure nécessaire d'isoler l'agent étiologique, de tester sa sensibilité par un « phagogramme », puis de produire la préparation thérapeutique).…”
Section: Applications Des Bactériophages En Médecine Humaineunclassified
“…Так, оценка приверженности амбулаторных педиатров национальным рекомендательным документам в Сербии показала, что показанные при тех или иных нозологиях антибактериальные препараты были выписаны всего в 1-17% случаев, таким образом, клиническим рекомендациям соответствовало лишь 19-28% назначений [9]. А анализ работы отделений неотложной педиатрии в Великобритании выявил практически полное отсутствие следования национальным клиническим рекомендациям, в частности относительно острых тонзиллитов (ОТ) [10].…”
Section: бронхопульмонология и лорunclassified