Antibiotics of Alcaligenes faecalis

Maré, I. J.; Coetzee, J. N.

doi:10.1038/203430a0

Cited by 4 publications

(3 citation statements)

References 4 publications

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“…8764 and A.T.C.C. 9220 were antagonistic against members of the same species as well as Escherichia (Maré and Coetzee, 1964) which is in agreement with our results. This same finding support also the results by Bacic and Yoch (2001) representing antibacterial activity of A. faecalis M3A, isolated from a swamp substrate, against not only all the indictor strains discussed above but also against P. aeruginosa, M. avium and M. tuberculosis.…”

Section: Spectrum Activitysupporting

confidence: 93%

A novel Alcaligenes faecalis antibacterial-producing strain isolated from a Moroccan tannery waste

Zahir¹,

Houari²,

Bahafid³

et al. 2013

Afr. J. Microbiol. Res.

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Drug resistance of many harmful bacteria still represents a real public health problem. This is why the development of new bioactive substance becomes urgent. To reach our goal, a screening of bioactive substance produced by microorganism, was undertaken. In this work, we reported data on a bacterial strain isolated from the tannery of Fez (Morocco) that showed a broad antagonistic effect against a group of Gram-negative and positive bacteria especially Mycobacterium smegmatis. The antibacterial compounds producer, BW1 was identified as Alcaligenes faecalis on the basis of phenotypic characteristics, biochemical analyses and PCR amplification of 16 S ribosomal RNA gene followed by sequencing (100% of homology). The antibacterial compounds were synthesized during the exponential growth phase of A. faecalis. The antibacterial compounds were not affected following heat treatment and protolytic enzymes that indicated the non-proteinaceous nature of the active agents. The bacterial extract was assayed for cellular toxicity to fresh human erythrocytes and found to have no hemolytic effect.

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Section: Spectrum Activitysupporting

confidence: 93%

A novel Alcaligenes faecalis antibacterial-producing strain isolated from a Moroccan tannery waste

Zahir¹,

Houari²,

Bahafid³

et al. 2013

Afr. J. Microbiol. Res.

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“…Enterococcus faecium isolated from traditional rigouta cheese was also found effective against Staphylococcus aureus (Ghrairi et al, 2008). Bacillus species isolated from cow dung showed significant antimicrobial effect , 1964;Alteri et al, 2009;Puah et al, 2016;Uppal et al, 2017).…”

Section: Biochemical Characterization Of Isolate Kd111mentioning

confidence: 98%

Preliminary study on inhibitory activity of Enterobacter sp. strain KD111 isolated from the Cow feces

Gupta

Rana

2018

Environ. Conserv. J.

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The objective of the present study was to isolate Enterobacter sp. from the faecal matter of cow followed by its screening for antimicrobial activity against Gram-positive and Gram-negative bacteria having clinical importance. On the basis of morphological and biochemical characterisation of seven isolates obtained from cow dung sample, isolate KD111 was probably identified as Enterobacter sp. and screened for its inhibitory activity against 14 test organisms comprising both Gram-positive and Gram-negative types using cross-streak method, in which both i.e. test organisms and isolates were streaked perpendicularly on nutrient agar plates followed by measurement of inhibition zone between the streaks after incubation. The preliminary screening revealed significant antimicrobial activity of Enterobacter sp. against Salmonella typhi (MTCC 3216), Escherichia coli, Staphylococcus aureus (MTCC 7443) and Bacillus cereus (MTCC 6728) with highest inhibition against Salmonella typhi (MTCC 3216) and Bacillus cereus (MTCC 6728). Our results indicate that Enterobacter sp. may act as a producer of bioactive antimicrobial metabolites and therefore should be analysed further for its possible application as therapeutic agent.

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“…It is known to be oxidase and cytochrome oxidase positive, catalase negative, glucose non fermenter, proteolytic and hydrolyze starch [ 13 ]. A. faecalis was examined for bacteriocin production by examining inhibitory effect against several microorganisms which were Salmonella , Escherichia , Serratia , Proteus , Staphylococci and Gram-positive aerobic bacilli [ 15 ]. In a study conducted by Zahir et al (2013), A. faecalis was isolated from soil sample and the extracted antimicrobial showed inhibitory effects against both Gram positive and Gram negative.…”

Section: Introductionmentioning

confidence: 99%

A Metagenomic Nanopore Sequence Analysis Combined with Conventional Screening and Spectroscopic Methods for Deciphering the Antimicrobial Metabolites Produced by Alcaligenes faecalis Soil Isolate MZ921504

Eltokhy

Saad²,

Eltayeb

et al. 2021

Antibiotics

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The continuous development of multidrug resistance pathogens with limited therapeutic options has become a great problem globally that impose sever health hazards. Accordingly, searching for of new antimicrobials became an urgent demand and great challenge. Soil significantly have been associated with several species that are antibiotic producers. In this study, combination of conventional screening methods with Liquid chromatography- Mass spectroscopy (LC/MS) and metagenomic nanopore sequence analysis have been conducted for the deciphering the active metabolites produced by soil isolate(s). Preliminary soil screening resulted in a Gram-negative isolate identified via 16S ribosomal RNA as Alcaligenes faecalis isolate MZ921504 with promising antimicrobial activities against wide range of MDR gram-positive and gram-negative pathogens. The LC/MS analysis of the metabolites of A. faecalis isolate MZ921504 confirmed the presence of ectoine, bacillibactin, quinolobactin and burkholderic acid. Metagenomics sequence analysis of the soil sample (NCBI GenBank accession PRJNA771993) revealed the presence of conserved biosynthetic gene clusters of ectoine, bacteriocin, bacillibactin, quinolobactin, terpene and burkholderic acid of A. faecalis. In conclusion, A. faecalis isolate MZ921504 is a promising source for antimicrobial metabolites. LC/MS spectral analysis and third generation sequencing tools followed by secondary metabolite gene clusters analysis are useful methods to predict the nature of the antimicrobial metabolites.

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Antibiotics of Alcaligenes faecalis

Cited by 4 publications

References 4 publications

A novel Alcaligenes faecalis antibacterial-producing strain isolated from a Moroccan tannery waste

A novel Alcaligenes faecalis antibacterial-producing strain isolated from a Moroccan tannery waste

Preliminary study on inhibitory activity of Enterobacter sp. strain KD111 isolated from the Cow feces

A Metagenomic Nanopore Sequence Analysis Combined with Conventional Screening and Spectroscopic Methods for Deciphering the Antimicrobial Metabolites Produced by Alcaligenes faecalis Soil Isolate MZ921504

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