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SUMMARYThe sodium azide resistance pattern of Proteus hauseri is not of the allor-none unilocal type reported for Escherichia coli but rather of the obligatory multi-step or penicillin variety. Independently isolated 1st-step resistant variants possessed similar degrees of resistance to sodium azide. Some properties of azide-resistant variants of P. hauseri are described. In support of the above finding it was possible to transduce 1st-step (and only 1st-step) resistance into the wild-type by phage grown on either 1st-, 2nd-, 3rd-or 4th-step resistant organisms. It was also possible to transduce 2nd-step resistance into 1st-step resistant organisms by phage developed on independently isolated 1st-step resistant organisms or by phage from multi-step resistant variants. About 60 yo of transduced genes expressed their phenotype in platings done immediately after the adsorption period. It is concluded that a number of loci, not closely linked, and possibly equipotent, control sodium azide resistance in P. hauseri and that resistance could be dominant to the wild allele.

GSSG via the pentose phosphate pa.thway is inadequate, the ability to synthesize glutathione impaired, or the sulphydryl stability of haemoglobin decreased; (e) GSH assumes a vital role when either normal or abnormal erythrocytes are exposed to aromatic catalysts, by helping to absorb the vastly increased oxidative potential, and thus with the aid of the process of methaemoglobin formation to buffer against irreversible damage.It is recognized that this unified concept may fail to account for possible contributory factors. The ideas are put forward in order to direct attention to the selectivity of different forms of oxidant haemolysin, and to emphasize the variable significance of the protective role of GSH in different types of human erythrocyte placed under varying degrees and types of oxidative stress.

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