Antibiotikaprophylaxe mit Enoxacin bei extrakorporaler Stoßwellenlithotripsie

Abstract

According to literature, 16 to 35% of operatively removed renal stones harbour bacteria. The efficacy of antibiotic prophylaxis with enoxacin in reducing the rate of bacteriuria after extracorporeal shock wave lithotripsy (ESWL) was investigated in a prospective randomized study. Twenty-five patients received a single 400 mg dose of enoxacin one hour before ESWL, 25 patients did not receive an antibiotic. It was found that a single 400 mg dose of enoxacin one hour before ESWL can reduce the rate of bacteriuria significantly.

CUA Guidelines on antibiotic prophylaxis for urologic procedures

“…Eight met the eligibility criteria for final inclusion in the systematic review. [8][9][10][11][12][13][14][15] Eight controlled trials randomized a total of 940 study participants ( Table 1). The incidence of UTI and fever were 4.2% and 3.4%, respectively.…”

Antibiotic Prophylaxis for Shock Wave Lithotripsy in Patients with Sterile Urine Before Treatment May be Unnecessary: A Systematic Review and Meta-Analysis

“…19,21 The reasons for excluding the 3 RCTs were the evaluation of the effect of antibiotic prophylaxis instead of treatment, 7 the incomplete description of methodology and results, 6 and the inconsistency between results and conclusions. 5 This was also supported by a structured literature review by Bootsma et al 23 that considered merely 4 RCTs, including only 3 of the 8 RCTs in the meta-analysis by Pearle and Roehrborn. 4 There are several limitations to the present study.…”

“…27 A previous meta-analysis on this subject published by Pearle and Roehrborn in 1997 included 8 RCTs. 4 Our meta-analysis was on 9 RCTs, excluding 3 RCTs in the study by Pearle and Roehrborn, [5][6][7] and including 2 RCTs released after their metaanalysis was compiled 13,16 and 2 RCTs not detected in their literature search. 19,21 The reasons for excluding the 3 RCTs were the evaluation of the effect of antibiotic prophylaxis instead of treatment, 7 the incomplete description of methodology and results, 6 and the inconsistency between results and conclusions.…”

Antibiotic prophylaxis in urological surgery, a European viewpoint

“…In a few follow-up studies, the frequency of post-ESWL bacteriuria has been shown to be ≤5% in patients without known risk factors [47][48][49]. In only one [50] of five randomized placebo/non-antibiotic-controlled studies was a significant reduction demonstrated [50][51][52][53][54]. In most studies, the sample size or the frequencies of infections were low and no clear-cut conclusions could be drawn.…”