Antibodies Against Glycoprotein 2 Are Specific Biomarkers for Pediatric Crohn’s Disease

Shpoliansky, Michael; Roggenbuck, Dirk; Pinsker, Marina; Salamon, Naomi; Weiss, Batia; Shouval, Dror S.; Werner, Lael

doi:10.1007/s10620-020-06589-5

Cited by 3 publications

(3 citation statements)

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“…с БК (анти-GP2-IgG -97,9%) по сравнению с пациентами с ЯК [31,34]. Ряд авторов выделяют дополнительно антитела к основному гликопротеину зимогена GP2 (MZGP2) [31].…”

Section: серологические маркеры взк: классификация и краткая характер...unclassified

Clinical and Diagnostic Value of Inflammatory Bowel Diseases' Serological Markers in Children (Literature Review)

Kamalova,

Khanafina,

Garina

2023

Pediatr. farmakol.

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The prevalence of inflammatory bowel diseases (IBD) is increasing worldwide. Crohn's disease (CD) and ulcerative colitis (UC) are characterized by chronic progressive course, high frequency of complications, and high risk of surgical treatment. Up to 50% of CD patients die due to its complications, and quarter of these patients require at least one surgery during their lifetime. IBD patients have 8 times higher risk of colorectal and small intestine cancer. IBD diagnosis can be established during childhood in 25% of cases. Early intensified therapy of individual patient groups could significantly reduce complications and surgical treatment rates. However, nowadays there are no reliable prognostic criteria for the unfavorable course of IBD. The aim of this review is to define the most studied IBD serological markers and to evaluate immune reactivation role in CD and UC course in children.

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Section: серологические маркеры взк: классификация и краткая характер...unclassified

Clinical and Diagnostic Value of Inflammatory Bowel Diseases' Serological Markers in Children (Literature Review)

Kamalova,

Khanafina,

Garina

2023

Pediatr. farmakol.

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“…These antibodies cross-react with the OmpC protein, suggesting a possible role for B cell autoreactivity and gut microbial antigenic cross-reactivity in the pathogenesis of IBD ( 139 ). Likewise, IBD has been associated with autoantibody responses against Glycoprotein 2 (GP2) ( 100 , 101 ), a receptor for bacterial adhesin FimH that is upregulated in the gut epithelium of patients ( 100 ). Of note, high levels of anti-GP2 IgA antibodies have been described in pediatric IBD patients ( 101 ).…”

Section: Gut Microbiota – Autoimmune Disease Associationsmentioning

confidence: 99%

“…Likewise, IBD has been associated with autoantibody responses against Glycoprotein 2 (GP2) ( 100 , 101 ), a receptor for bacterial adhesin FimH that is upregulated in the gut epithelium of patients ( 100 ). Of note, high levels of anti-GP2 IgA antibodies have been described in pediatric IBD patients ( 101 ). An increased prevalence of autoantibodies against FAM84A, a neuronal sensory protein expressed in the gastrointestinal tract, has also been associated with IBD ( 102 ).…”

Section: Gut Microbiota – Autoimmune Disease Associationsmentioning

confidence: 99%

Gut Microbial Antigenic Mimicry in Autoimmunity

Garabatos

Santamaría

2022

Front. Immunol.

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The gut microbiota plays a major role in the developmental biology and homeostasis of cells belonging to the adaptive and innate arms of the immune system. Alterations in its composition, which are known to be regulated by both genetic and environmental factors, can either promote or suppress the pathogenic processes underlying the development of various autoimmune diseases, including inflammatory bowel disease, multiple sclerosis, systemic lupus erythematosus, type 1 diabetes and rheumatoid arthritis, to just name a few. Cross-recognition of gut microbial antigens by autoreactive T cells as well as gut microbe-driven alterations in the activation and homeostasis of effector and regulatory T cells have been implicated in this process. Here, we summarize our current understanding of the positive and negative associations between alterations in the composition of the gut microbiota and the development of various autoimmune disorders, with a special emphasis on antigenic mimicry.

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