Antibodies against vaccine-preventable diseases in pregnant women and their offspring in the eastern part of Germany

Sauerbrei, Andreas; Groh, A; Bischoff, A.; Prager, J; Wutzler, Peter

doi:10.1007/s00430-001-0100-3

Cited by 29 publications

(22 citation statements)

References 23 publications

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“…However, there are no well-defined criteria for evaluating the results of seroepidemiology of pertussis (5,9,12). Moreover, although cellular immunity lasts much longer than it used to, the titer of antibodies appears to decrease quickly after infection or vaccination, with either whole-cell or acellular vaccines (2,12).…”

Section: Discussionmentioning

confidence: 94%

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Sero epidemiology of Bordetella pertussis immune responses in a healthy population in northern Greece

Polyzou

Pournaras

Dafni

et al. 2004

Clinical Laboratory Analysis

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A seroepidemiological study was conducted on a representative sample of the northern Greek population (healthy individuals, age range=1 day to 80 years) to assess the prevalence of antibodies to pertussis toxin (PT) and filamentous hemagglutinin (FHA). Antibody concentrations were significantly elevated with age (analysis of variance (ANOVA), P<0.001). In addition, a significant increase in antibody levels was detected in subjects >50 years old compared to children aged 5-10 years (post-hoc Scheffe analysis, P=0.007). These data suggest that pertussis occurs frequently in Greek adults, and that sometimes a fifth booster vaccine dose is not given after the second year of life. Routine revaccination with the acellular vaccine for children >4 years of age, adolescents, and adults should be considered in order to ensure effective protection of the whole population.

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Section: Discussionmentioning

confidence: 94%

“…Serodiagnosis of pertussis has been used as evidence to support the need for immunizations in various populations (9)(10)(11)(12). However, there are no well-defined criteria for evaluating the results of seroepidemiology of pertussis (5,9,12).…”

Section: Discussionmentioning

confidence: 98%

Sero epidemiology of Bordetella pertussis immune responses in a healthy population in northern Greece

Polyzou

Pournaras

Dafni

et al. 2004

Clinical Laboratory Analysis

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“…In Greece in 1999 the incidence of CRS was 4 per 100 000 live births and in 2003, although 60%-80% of teenagers were vaccinated, 10%-20% of women of child-bearing age were susceptible to rubella [13]. In a survey in 2001 in Germany 37.6% of pregnant women had history of rubella vaccination and 86.6% of samples were IgG positive for rubella [14].…”

Section: Discussionmentioning

confidence: 99%

What do we need to eradicate rubella in the Islamic Republic of Iran?

Almassinokiani

Noorbakhsh²,

Rezaei³

et al. 2013

East Mediterr Health J

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To evaluate the need for congenital rubella syndrome prevention in our national health programme we aimed to determine the rate of anti-rubella positivity in umbilical cord blood samples 8 years after measlesrubella mass vaccination in the Islamic Republic of Iran. In a cross-sectional study we tested umbilical cord blood samples for anti-rubella IgG and IgM by ELISA in 154 deliveries at a university hospital in Tehran. Overall 72.7% of umbilical cord blood samples were positive for anti-rubella IgG and 27.3% were negative. All of the samples were negative for anti-rubella IgM. In the samples with a history of mothers' rubella vaccination, only 87.5% were positive for anti-rubella IgG. The results suggest the need for another mass vaccination for rubella in women of child-bearing age and continuation of routine vaccination of infants, plus consideration of obligatory anti-rubella IgG testing before pregnancy in women who were not vaccinated and vaccination of women before marriage. RÉSUMÉ Pour évaluer la nécessité d'intégrer la prévention du syndrome de rubéole congénitale dans notre programme de santé national, nous avons tenté de déterminer le taux de positivité aux anticorps antirubéoleux dans des échantillons de sang de cordon ombilical huit ans après la campagne de vaccination de masse contre la rougeole et la rubéole en

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“…If there is no reported history of varicella, antibodies are in any case present in 70%-90% of cases [54,[302][303][304][305][306] . The seroprevalence rate is high in industrialised and/or temperate climate countries [99,150,301,[307][308][309][310][311][312][313][314][315][316][317][318][319][320][321] (Table 1).…”

Section: Risk Of Transmissionmentioning

confidence: 99%

Microbiology laboratory and the management of mother-child varicella-zoster virus infection

Paschale

Clerici

2016

WJV

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Varicella-zoster virus, which is responsible for varicella (chickenpox) and herpes zoster (shingles), is ubiquitous and causes an acute infection among children, especially those aged less than six years. As 90% of adults have had varicella in childhood, it is unusual to encounter an infected pregnant woman but, if the disease does appear, it can lead to complications for both the mother and fetus or newborn. The major maternal complications include pneumonia, which can lead to death if not treated. If the virus passes to the fetus, congenital varicella syndrome, neonatal varicella (particularly serious if maternal rash appears in the days immediately before or after childbirth) or herpes zoster in the early years of life may occur depending on the time of infection. A Microbiology laboratory can help in the diagnosis and management of mother-child infection at four main times: (1) when a pregnant woman has been exposed to varicella or herpes zoster, a prompt search for specific antibodies can determine whether she is susceptible to, or protected against infection; (2) when a pregnant woman develops clinical symptoms consistent with varicella, the diagnosis is usually clinical, but a laboratory can be crucial if the symptoms are doubtful or otherwise unclear (atypical patterns in immunocompromised subjects, patients with post-vaccination varicella, or subjects who have received immunoglobulins), or if there is a need for a differential diagnosis between varicella and other types of dermatoses with vesicle formation; (3) when a prenatal diagnosis of uterine infection is required in order to detect cases of congenital varicella syndrome after the onset of varicella in the mother; and (4) when the baby is born and it is necessary to confirm a diagnosis of varicella (and its complications), make a differential diagnosis between varicella and other diseases with similar symptoms, or confirm a causal relationship between maternal varicella and malformations in a newborn. Core tip: Although varicella during pregnancy is infrequent and congenital varicella syndrome (CVS) is rare, every available means should be used to prevent and diagnose them. Microbiology laboratories can be crucial in these situations: Evaluating a mother's immune status with sensitive and specific tests for the detection of antibodies; allowing a rapid diagnosis with molecular biology tests when a clinical manifestation may be due to different etiologies; following pregnant women with varicella for the prenatal diagnosis of CVS with close collaboration between molecular biology investigators and specialists in imaging diagnostics.De Paschale M, Clerici P. Microbiology laboratory and the management of mother-child varicella-zoster virus infection. World

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Antibodies against vaccine-preventable diseases in pregnant women and their offspring in the eastern part of Germany

Cited by 29 publications

References 23 publications

Sero epidemiology of Bordetella pertussis immune responses in a healthy population in northern Greece

Sero epidemiology of Bordetella pertussis immune responses in a healthy population in northern Greece

What do we need to eradicate rubella in the Islamic Republic of Iran?

Microbiology laboratory and the management of mother-child varicella-zoster virus infection

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