Sero epidemiology of <i>Bordetella pertussis</i> immune responses in a healthy population in northern Greece

Polyzou, Aikaterini; Pournaras, Spyros; Dafni, Urania; Sofianou, Danai; Christeli, E.; Patrinos, Stavros; Tsakris, Athanassios

doi:10.1002/jcla.20025

Cited by 9 publications

(8 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the age groups up to 19 years, the percentage of samples with high titres remained stable at 5–7·9%, reflecting natural boosting and limited vaccination of the 5–9 years age group. The data from this study seem to confirm the circulation of B. pertussis in age groups not generally considered to be involved in the circulation of this pathogen, because of vaccination or natural immunity, and support previous reports in Italy and in other countries [36, 37].…”

Section: Discussionsupporting

confidence: 90%

Assessment of humoral and cell-mediated immunity againstBordetella pertussisin adolescent, adult, and senior subjects in Italy

et al. 2008

View full text Add to dashboard Cite

SUMMARYHumoral and cell-mediated immunity (CMI) against B. pertussis was assessed in a sample of adolescent, adult and senior subjects distributed in five different geographical areas in Italy. Most (99 . 1 %) subjects had IgG anti-pertussis toxin (PT) antibodies exceeding the minimum detection level [o2 ELISA units (EU)/ml]. There were no significant differences between the genders ; 6 . 2 % samples recorded titres o100 EU/ml. CMI was positive [stimulation index (SI) o5] against PT in 39 . 0 % of all samples. This study suggests that B. pertussis continues to circulate in age groups that have been previously considered to be uninvolved in the circulation of this pathogen and that adolescent and adult pertussis boosters may be of value in these populations. Nevertheless, over the last 10 years, large increases in vaccination coverage rates have contributed to reduce the spread of the aetiological agent, especially in the immunized population.

show abstract

Section: Discussionsupporting

confidence: 90%

Assessment of humoral and cell-mediated immunity againstBordetella pertussisin adolescent, adult, and senior subjects in Italy

et al. 2008

View full text Add to dashboard Cite

show abstract

“…Infection does not confer life-long protection, and after vaccination antibody levels decrease even faster [4]. The large proportion of seropositive persons among adults vaccinated before age 40 and among unvaccinated adults over 40 suggests reinfection with B. pertussis, as has already been demonstrated in other studies [22,23].…”

Section: Discussionsupporting

confidence: 54%

Seroprevalence of IgG antibodies to pertussis toxin in the Slovene population

Sočan¹,

Prosenc²,

Vegnuti

2006

Wien Klin Wochenschr

View full text Add to dashboard Cite

show abstract

“…An overview of epidemiology studies from Southern European countries is shown in Table 4 . This included studies from Cyprus [ 99 ], Greece [ 100 , 101 ], Italy [ 102 – 110 ], Portugal [ 85 ] and Spain [ 111 – 127 ].…”

Section: Epidemiologymentioning

confidence: 99%

“…This included studies from Cyprus [ 99 ], Greece [ 100 , 101 ], Italy [ 102 – 110 ], Portugal [ 85 ] and Spain [ 111 – 127 ].…”

Section: Epidemiologymentioning

confidence: 99%

“…In addition, a significant increase in antibody levels was detected in adults aged > 50 years compared with children aged 5–10 years (post-hoc Scheffé analysis, p = 0.007). These data suggest that pertussis occurs frequently in Greek adults and that sometimes a fifth booster vaccine dose is not given after the second year of life [ 101 ]. In another study in Greece in 2009, based on 373 adults aged 17–65 years, there were three groups: 283 children who were hospitalised with the clinical diagnosis of pertussis, 57 household contacts of 57 children with PCR-confirmed pertussis and 33 adults who suffered from chronic cough.…”

Section: Epidemiologymentioning

confidence: 99%

See 1 more Smart Citation

Bordetella pertussis in School-Age Children, Adolescents and Adults: A Systematic Review of Epidemiology and Mortality in Europe

Macina

Evans

2021

Infect Dis Ther

View full text Add to dashboard Cite

Pertussis (whooping cough) epidemics persist globally despite high vaccine coverage among infants and young children. The resurgence of pertussis in high-income countries is partly due to waning vaccine immunity, resulting in a pool of unprotected adolescents and adults. However, pertussis is generally less severe in adolescents and adults, and this difference in presentation means it can often be unrecognised by healthcare professionals, meaning that it is largely under-diagnosed in older populations. A systematic search of MEDLINE, EMBASE and BIOSIS was undertaken to identify studies published between 1 January 1990 and 17 June 2019, with information on pertussis epidemiology and mortality in school-aged children, adolescents and adults in Europe. A formal statistical comparison (e.g. using meta-analyses) was not possible because of the mix of methodologies reported. There were 69 epidemiological studies and 19 mortality studies identified for review. Over the past decade, the reported incidence of notified pertussis cases varied widely between European countries, which is likely associated with differences in surveillance systems, diagnostic techniques and reporting regulations. However, several studies show that pertussis is circulating among adolescents and adults in Europe, and although pertussis-related morbidity and mortality are highest in infants, there is evidence that adults aged > 50 years are at increased risk. For example, in a hospital-based surveillance study in Portugal, between 2000 and 2015, 94% of hospitalised pertussis cases were infants aged < 1 year, with a case fatality rate (CFR) of 0.8%; however, among hospitalised adult cases of pertussis, the CFRs were 11.5% (aged 18–64 years) and 17.4% (aged > 65 years). Very few European countries currently include pertussis boosters for adults in the national immunisation strategy. In addition to increasing pertussis vaccination coverage in adolescents and adults, mitigation strategies in European countries should include improved diagnosis and treatment in these populations. Supplementary Information The online version contains supplementary material available at 10.1007/s40121-021-00520-9.

show abstract

Sero epidemiology of Bordetella pertussis immune responses in a healthy population in northern Greece

Cited by 9 publications

References 16 publications

Assessment of humoral and cell-mediated immunity againstBordetella pertussisin adolescent, adult, and senior subjects in Italy

Assessment of humoral and cell-mediated immunity againstBordetella pertussisin adolescent, adult, and senior subjects in Italy

Seroprevalence of IgG antibodies to pertussis toxin in the Slovene population

Bordetella pertussis in School-Age Children, Adolescents and Adults: A Systematic Review of Epidemiology and Mortality in Europe

Contact Info

Product

Resources

About