Seroprevalence of IgG antibodies to pertussis toxin in the Slovene population

Sočan, Maja; Prosenc, Katarina; Vegnuti, Miljana

doi:10.1007/s00508-006-0609-y

Cited by 12 publications

(10 citation statements)

References 19 publications

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“…Similar to most studies, we found no significant difference in the level of pertussis antibodies between boys and girls (17,19). However in one study girls had higher antibody levels than boys; however, the authors did not discuss any reasons for this difference (9).…”

Section: Discussionsupporting

confidence: 70%

Seroprevalence of pertussis antibodies in 6-17-year-old students in Ahvaz, south-west Islamic Republic of Iran

Shamsizadeh¹,

Nikfar²,

Yusefi³

et al. 2014

East Mediterr Health J

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Although pertussis is a vaccine-preventable infection, vaccine-induced immunity is not lifelong and booster doses are recommended according to national disease epidemiology. The aim of this study was to evaluate pertussis-IgG levels in school-aged students in Ahvaz, south-west Islamic Republic of Iran. In a descriptive, crosssectional study, blood samples were obtained from 640 students (382 boys and 258 girls) aged 6-17 years during 2010-2011. All students had received a full course of pertussis whole-cell vaccination at ages 2, 4, 6 and 18 months and 4-6 years. Using a Bordetella IgG ELISA kit, pertussis-IgG was detected in 301 (47.0%) students. No statistically significant differences in pertussis-IgG levels were found between girls and boys or across different age groups. The findings show that the overall level of pertussis-IgG seropositivity was unacceptable. Booster vaccination with an acellular pertussis vaccine should be considered in adolescents and/or adults in our region. ‫اإلسالمية‬ ‫إيران‬ ‫مجهورية‬ ‫غرب‬ ‫بجنوب‬ ‫األهواز،‬ ‫يف‬

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Section: Discussionsupporting

confidence: 70%

Seroprevalence of pertussis antibodies in 6-17-year-old students in Ahvaz, south-west Islamic Republic of Iran

Shamsizadeh¹,

Nikfar²,

Yusefi³

et al. 2014

East Mediterr Health J

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“…Gender did not influence the seroimmunity in our study; the same was reported by several other investigators. [23][24][25][26] In the current study, serum pertussis IgG titres increased with age among the infants' group being lowest below 6 months of age and higher in the 12 to 24 months old which is expected due to the receival of booster doses of the vaccine. A relevant study showed that pertussis antibody levels >30 U/ml were observed with higher frequency in infants younger than 2 years of age who completed the vaccination schedule .…”

Section: Discussionmentioning

confidence: 51%

“…27 Another study revealed that vaccinated 1-2-year-old infants and 17-18-year-old adolescents had the highest serum pertussis IgG titers. 24 An interesting observation in a group of Turkish children was that pertussis antibodies increased after the age of 6 years and a further increase was observed between 7 and 12 years. Since there is no booster against pertussis at this age, this increase probably reflects the acquisition of natural immunity following the beginning of elementary school, where children join a new crowded community with higher rates of exposure to communicable diseases.…”

Section: Discussionmentioning

confidence: 98%

Pertussis seroimmunity in mother-neonate pairs and other pediatric age groups from Egypt

Hossny

El‐Ghoneimy

Soliman

et al. 2019

Egypt J Pediatr Allergy Immunol

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Background: Despite the widespread availability of 2 classes of effective vaccines, whole cell and acellular, pertussis has resurged as a serious public health problem. We sought to investigate the pertussis immune status of mother-neonate pairs and children in our country where pertussis vaccination is obligatory. Methods: This cross-sectional study included 75 healthy full-term neonates and their mothers, 100 infants (2-24 months), 170 children (2-12 years) and 80 adolescents (12-18 years). Serum pertussis IgG was measured in all enrolled subjects. A positive titre was defined as >24 U/ml. Results: Positive pertussis IgG levels were detected in 69 of the mothers (92%), in 63 of their newborns (84%). Seroimmunity to pertussis was positively noted in 55% of infants, 82.2% of preschool children, 77.5% of school-aged children and 75% in adolescents. Serum pertussis IgG titers among the neonates showed a significant positive correlation with the maternal titers (P=0.00001). Higher rates of pertussis seroimmunity was observed among residents in urban and suburban areas as compared to those living in rural areas (P<0.05). Conclusion: This pilot study may suggest the presence of sufficient pertussis seroimmunity rates in the studied age groups. Still, there were some failures in immune acquisition probably due to inefficient vaccination in some localities or waning of immunity with age. Wider scale studies would allow better insight into the pertussis immune status in our country and hence the need for booster immunization.

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“…Seroprevalence studies have shown increasing susceptibility of adolescents and younger adults for pertussis infection [27]. Epidemiological data have demonstrated a marked shift in age distribution among pertussis cases, with a rise in the number of cases among school children and adolescents [28]. Our finding of a high percentage of students who were seropositive for pertussis probably reflects reinfections.…”

Section: Discussionmentioning

confidence: 78%

High seroprevalence of varicella, measles, mumps, rubella and pertussis antibodies in first-grade medical students

Sočan¹,

Berginc²

2008

Wien Klin Wochenschr

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The rates of varicella, measles, mumps and rubella immunity in first-grade medical students are very high. To identify those students who need vaccination before commencing practical work in healthcare facilities, a meticulous disease and vaccination history should be taken and medical records should be reviewed. Medical students providing no written evidence of adequate vaccination status should be serologically tested and vaccinated if necessary.

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Seroprevalence of IgG antibodies to pertussis toxin in the Slovene population

Cited by 12 publications

References 19 publications

Seroprevalence of pertussis antibodies in 6-17-year-old students in Ahvaz, south-west Islamic Republic of Iran

Seroprevalence of pertussis antibodies in 6-17-year-old students in Ahvaz, south-west Islamic Republic of Iran

Pertussis seroimmunity in mother-neonate pairs and other pediatric age groups from Egypt

High seroprevalence of varicella, measles, mumps, rubella and pertussis antibodies in first-grade medical students

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