Antibodies against varicella‐zoster virus and herpes simplex virus deoxythymidine kinase in heterologous infections

Källander, C. F. R.; Torfason, Einar G.; Olding-Stenkvist, Elisabeth; Sundqvist, Vivi‐Anne; Diderholm, Hans; Gronowitz, J. S.

doi:10.1002/jmv.1890280108

Cited by 3 publications

(2 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The CF reaction is common and useful for the confirmation of an attack of varicella. However, herpes simplex virus (HSV) may have common antigens with varicella-zoster virus [6]. An active varicella-zoster virus infection is diagnosed by detective specific IgM or IgG antibody.…”

Section: Case Reportmentioning

confidence: 99%

A case of herpes zoster affecting the glossopharyngeal nerve

Tamakawa

Takada²

1999

Journal of Anesthesia

View full text Add to dashboard Cite

not eat because of a sore throat, which was confined to the right side of pharynx. She also complained of absence of taste on the right side of the tongue and of absence of sweet taste on the left side of the tongue. Small vesicles were seen on the right portion of the soft palate and the right palatine tonsil (Fig. 1). No other cranial nerve seemed to be affected.Complement-fixing (CF) antibody titers for varicellazoster were 1 : 32 (the normal range is less than 4 times), and varicella-zoster virus IgG (VZVIgG) titers on enzyme immunoassay were 103.2 (the normal range is less than 2.0). Using the PCR technique, we then found pieces of DNA specific for varicella-zoster virus in specimens from the vesicle and peripheral blood samples (Fig. 2). We diagnosed her as suffering from herpes zoster. She was admitted the day following the definitive diagnosis.After admission, the patient was given acyclovir 800 mg five times per day orally for 5 days and loxoprofen sodium 180 mg three times per day orally for 14 days. A stellate ganglion block with 5 ml of 1% mepivacaine was also performed for 28 days. The patient could eat liquid food three days after admission. CF antibody titers and VZVIgG titers decreased over several days. The vesicles became crusted 7 days after the commencement of treatment. The pain in the right ear and the sore throat were relieved within 1 month. Taste recovered completely on the left side of the tongue within 1 month, but absence of taste on the right side of the tongue has persisted. DiscussionThe patient complained of stabbing pain in the right ear. The glossopharyngeal nerve innervates the soft palate, the palatine tonsil, and the pharynx. It also detects taste from the posterior third of the tongue. The patient complained of loss of taste on the whole right

show abstract

Section: Case Reportmentioning

confidence: 99%

A case of herpes zoster affecting the glossopharyngeal nerve

Tamakawa

Takada²

1999

Journal of Anesthesia

View full text Add to dashboard Cite

show abstract

“…Notably, research has uncovered an interesting phenomenon: an increase in antibody levels against HSV-deoxyThymidine Kinase (dTK) during VZV infections. 10 The virus-encoded thymidine kinase for both HSV and VZV is a target for future treatments. 11 This finding raises the prospect of developing a comprehensive treatment approach that could target a broad spectrum of human herpes viruses (HHV) within the alpha subfamily.…”

Section: Introductionmentioning

confidence: 99%

Is the level of varicella-zoster virus IgG associated with symptomatic status of genital herpes simplex virus infection? A case-control study

Palmer,

Tang,

Winchester

et al. 2023

Int J STD AIDS

View full text Add to dashboard Cite

Background Herpes simplex virus (HSV) is a common infection, affecting the majority of the population by age of 50. Recurrent symptomatic outbreaks, experienced by a minority, have significant psychological and psychosexual effects. The varicella zoster virus (VZV), resembling HSV, shows potential for a functional cure via vaccination. This study seeks to investigate if there is an association between low VZV antibody levels and recurrent HSV outbreaks. Methods A total of 110 patients with symptomatic and asymptomatic HSV were recruited during their sexual health screen. Serum samples were collected between Aug 2019 - July 2022; breaks in the study occurred due to COVID. The primary outcome measure was the serological status of HSV and VZV IgG titre level. Results The average age was 37.3 years (range 21–65 years). For people with asymptomatic genital HSV2 the average VZV IgG titre was 2373.9 IU/mL ( n = 17); and 1219.0 IU/mL for the symptomatic group ( n = 67); p ≤ 0.00001), with similar results for HSV1. Conclusion There is a strong association between average higher varicella-zoster virus (VZV) IgG level and being an asymptomatic carrier of herpes simplex sirus (HSV)1&2. A feasibility study to assess the use of the VZV vaccine as a treatment of HSV is planned.

show abstract

Reactivity of varicella-zoster virus subunit antigens in enzyme-linked immunosorbent assay to sera from varicella, zoster, and herpes simplex virus infections

Takayama

1994

Med Microbiol Immunol

View full text Add to dashboard Cite

Serological responses to varicella-zoster virus (VZV) subunit antigens, such as capsid, envelope, and soluble (S) antigens, in patients with VZV and herpes simplex virus (HSV) infections were studied by comparing with responses to virion (V) antigens using an enzyme-linked immunosorbent assay (ELISA). S antigen, prepared by concentrating supernatant of VZV or HSV type 1 (HSV-1)-infected cell culture fluid, reacted strongly to sera from patients with secondary infection but reacted poorly to those from patients with a primary infection of VZV or HSV. Antibody titers to VZV-S antigen persisted for a long period in patients with VZV infections. Patients infected with VZV showed antibody increase to HSV-1, when tested by complement fixation or complement-enhanced neutralization test, in cases with a history of prior HSV infection. However, such a cross-reaction was only observed to a minor extent in ELISA test using S antigen. S antigen reaction was stronger in secondary infections in tests with various subunit antigens. Almost no cross-reactivity was observed in an immunoblotting test with S antigen. Differentiation between infections with either varicella or zoster or HSV can be made by comparison of antibody responses to V and S antigens.

show abstract

Antibodies against varicella‐zoster virus and herpes simplex virus deoxythymidine kinase in heterologous infections

Cited by 3 publications

References 15 publications

A case of herpes zoster affecting the glossopharyngeal nerve

A case of herpes zoster affecting the glossopharyngeal nerve

Is the level of varicella-zoster virus IgG associated with symptomatic status of genital herpes simplex virus infection? A case-control study

Reactivity of varicella-zoster virus subunit antigens in enzyme-linked immunosorbent assay to sera from varicella, zoster, and herpes simplex virus infections

Contact Info

Product

Resources

About