Antibodies Against β<sub>2</sub>‐Glycoprotein I Complexed With an Oxidised Lipoprotein Relate to Intima Thickening of Carotid Arteries in Primary Antiphospholipid Syndrome

Ames, P. R. J.; Alves, José Delgado; Lopez, Luis R.; Gentile, Fabrizio; Margarita, Annamaria; Pizzella, Luciano; Batuca, Joana R.; Scenna, G.; Brancaccio, Vincenzo; Matsuura, Eiji

doi:10.1080/17402520600554930

Cited by 21 publications

(9 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PONa inversely correlated to the carotid IMT. IgG anti-β2-GPI/oxLig1 may be involved in PAPS-related atherogenesis via decreased PON activity [37].…”

Section: Atherosclerosis and Antiphospholipid Syndrome Clinical Evidmentioning

confidence: 99%

Systemic Antiphospholipid Syndrome and Atherosclerosis

Jara

Medina

Vera‐Lastra

2007

Clinic Rev Allerg Immunol

View full text Add to dashboard Cite

Atherosclerosis (AT) is a metabolic, systemic inflammatory/immune disease characterized by lipoproteins metabolism alteration that leads to immune/inflammatory system activation with the consequent proliferation of smooth-muscle cells, narrowing arteries and atheroma formation. Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by thrombophilic state and circulating antiphospholipid antibodies (aPL) including anti beta2-GPI. Experimental studies and human observations suggest that APS is associated with AT. In fact, innate and adaptive immune responses participate in the pathogenesis of both diseases. Anti-oxLDL, anti-aPL, anti beta2GPI, anti-HSP antibodies, among others, has been found in patients with APS and AT. Endothelial dysfunctions, oxidative stress, increase of cell adhesion molecules, active platelets, are common findings in both diseases. Macrophages, dendritic cells, T-cell activation, CD40-CD40 ligand interaction, are considered as pathogenic mechanism of AT and APS. Premature AT may be the first symptom of APS. Thrombophilia, aPL antibodies, and APS may be present in patients with premature AT. An association between AT and venous thrombosis (a clinical hallmark of APS) has been proposed in unselected patients with deep venous thrombosis of the legs without symptomatic AT. Asymptomatic AT, defined in terms of carotid intima media thickness and lumen diameter decrease, was observed in patients with APS. Premenopausal female patients with PAPS have a higher prevalence of cerebrovascular disease in comparison with male patients. Accelerated AT and hormones could be the explanation of these findings. High levels of aCLs, significantly predict the risk of future ischemic stroke in women but not in men. AT is one of the main features of systemic APS and offer opportunities for new treatment strategies.

show abstract

“…PONa inversely correlated to the carotid IMT. IgG anti-β2-GPI/oxLig1 may be involved in PAPS-related atherogenesis via decreased PON activity [37].…”

Section: Atherosclerosis and Antiphospholipid Syndrome Clinical Evidmentioning

confidence: 99%

Systemic Antiphospholipid Syndrome and Atherosclerosis

Jara

Medina

Vera‐Lastra

2007

Clinic Rev Allerg Immunol

View full text Add to dashboard Cite

show abstract

“…Ames et al . described a direct association of IgG anti‐oxLDL–β2‐GP1 complexes with IMT in primary antiphospholipid syndrome (PAPS), suggesting a potential atherogenic role of these antibodies 42 …”

Section: Anti‐oxldl‐β2‐gp1 Complex Antibodiesmentioning

confidence: 99%

“…6 Ames et al described a direct association of IgG anti-oxLDL-β2-GP1 complexes with IMT in primary antiphospholipid syndrome (PAPS), suggesting a potential atherogenic role of these antibodies. 42 Another aspect is that oxLDL-β2-GP1 complex binds C-reactive protein (CRP). 43 CRP is an acute-phase plasma protein principally expressed and induced in the liver under the regulation of the proinflammatory cytokines IL-1, IL-6, and TNF-α, although nonacute-phase elevations may occur in several chronic inflammatory diseases, such as RA and atherosclerosis.…”

Section: Anti-oxldl-β2-gp1 Complex Antibodiesmentioning

confidence: 99%

Humoral Mechanisms of Atherogenesis

Batuca

Amaral

Alves

2009

Annals of the New York Academy of Sciences

Self Cite

View full text Add to dashboard Cite

The concept that atherosclerosis is an autoimmune disease is no longer controversial. Attention has been paid to cellular immune response, but current research is now focused on the humoral component of this complex disease. Heat shock proteins, oxidized low-density lipoproteins, beta2-glycoprotein 1, cardiolipins, and, more recently, high-density lipoproteins have been considered to be autoantigens that play a part in atherogenesis. The characterization and understanding of the mechanisms associated with the presence of these antigens and their respective autoantibodies might contribute to elucidating the atherosclerotic process. In the near future, immune modulation might constitute a very effective therapy of atherosclerosis.

show abstract

“…oxLDL can bind to β2-GPI and form β2-GPI/oxLDL complexes [ 21 – 23 ], prompting macrophages to phagocytize oxLDL through the β2-GPI autoantibody-mediated pathway, thus inducing the formation of foam cells that participate in atherosclerosis and vascular diseases. It has been shown that the plasma levels of β2-GPI/oxLDL complexes are significantly increased in patients with microvascular diseases such as chronic inflammatory response and some autoimmune diseases [ 24 – 27 ], as well as with macrovascular diseases [ 28 – 30 ] and T2DM [ 24 , 31 ]. Nevertheless, the exact contribution of β2-GPI/oxLDL to the occurrence of cerebral infarction in T2DM is still poorly understood.…”

Section: Introductionmentioning

confidence: 99%

Elevated Levels of Serum β2-Glycoprotein I/Oxidized Low-Density Lipoprotein Complexes Are Associated with Cerebral Infarction in Patients with Type 2 Diabetes Mellitus

et al. 2018

View full text Add to dashboard Cite

BackgroundTo determine whether the levels of β2-glycoprotein I (β2-GPI)/oxidized low-density lipoprotein (oxLDL) complexes are correlated with cerebral infarction in patients with type 2 diabetes mellitus (T2DM).Material/MethodsThe levels of β2-GPI/oxLDL complexes, oxLDL, routine lipid/lipoprotein parameters, oxidative stress molecules, and inflammatory factors were measured in 78 healthy controls, 82 diabetics without cerebral infarction, and 79 diabetics with cerebral infarction. Correlation, multiple linear regression, and logistic regression analyses were performed.ResultsSerum β2-GPI/oxLDL complexes and oxLDL levels were significantly elevated in cerebral infarction in patients with T2DM (β2-GPI/oxLDL: 1.09±0.16 U/mL; oxLDL: 47.83±8.17 mmol/L) compared with T2DM without cerebral infarction (β2-GPI/oxLDL: 0.95±0.13 U/mL; oxLDL: 41.24±7.12 mmol/L) and healthy controls (β2-GPI/oxLDL: 0.81±0.12 U/mL; oxLDL: 27.97±4.57 mmol/L). The levels of β2-GPI/oxLDL complex in lacunar infarction (1.16±0.15 U/ml) were significantly higher than atherothrombotic infarction (1.07±0.19 U/ml) and cardioembolic infarction (1.00±0.23 U/ml). In all patients with T2DM, the β2-GPI/oxLDL levels were positively correlated with total cholesterol (r=0.474, p=0.001) and triglycerides (r=0.431, p=0.003). oxLDL levels were positively correlated with total cholesterol (r=0.445, p=0.002). The logistic regression analysis indicated that elevated β2-GPI/oxLDL and oxLDL levels were independently associated with diabetic cerebral infarction.ConclusionsElevated levels of serum β2-GPI/oxLDL complexes are associated with cerebral infarction in patients with T2DM, especially in those with lacunar infarction.

show abstract

Antibodies Against β₂‐Glycoprotein I Complexed With an Oxidised Lipoprotein Relate to Intima Thickening of Carotid Arteries in Primary Antiphospholipid Syndrome

Cited by 21 publications

References 32 publications

Systemic Antiphospholipid Syndrome and Atherosclerosis

Systemic Antiphospholipid Syndrome and Atherosclerosis

Humoral Mechanisms of Atherogenesis

Elevated Levels of Serum β2-Glycoprotein I/Oxidized Low-Density Lipoprotein Complexes Are Associated with Cerebral Infarction in Patients with Type 2 Diabetes Mellitus

Contact Info

Product

Resources

About

Antibodies Against β2‐Glycoprotein I Complexed With an Oxidised Lipoprotein Relate to Intima Thickening of Carotid Arteries in Primary Antiphospholipid Syndrome

Cited by 21 publications

References 32 publications

Systemic Antiphospholipid Syndrome and Atherosclerosis

Systemic Antiphospholipid Syndrome and Atherosclerosis

Humoral Mechanisms of Atherogenesis

Elevated Levels of Serum β2-Glycoprotein I/Oxidized Low-Density Lipoprotein Complexes Are Associated with Cerebral Infarction in Patients with Type 2 Diabetes Mellitus

Contact Info

Product

Resources

About

Antibodies Against β₂‐Glycoprotein I Complexed With an Oxidised Lipoprotein Relate to Intima Thickening of Carotid Arteries in Primary Antiphospholipid Syndrome