ANTIBODIES OF THE IgA TYPE IN INTESTINAL PLASMA CELLS OF GERMFREE MICE AFTER ORAL OR PARENTERAL IMMUNIZATION WITH FERRITIN

Crabbé, P. A.; Nash, Donald R.; Bazin, Hervé; Eyssen, H.; Heremans, J. F.

doi:10.1084/jem.130.4.723

Cited by 190 publications

(57 citation statements)

References 27 publications

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“…Although previous studies ascribed a role of T reg presence and function for IgA synthesis [27,28,30,31,35,36,37,38,39,40], these data were challenged by other investigations [41,42]. While the authors of the former believed that IgA production strongly depended on the innate immune system, particularly toll like receptor 7 and 9 activation of B cells, they cannot connive the role of T reg in TGF-β-induced IgA switching during the first 24 h [42,43,44,45].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Natural Regulatory T Cells in Subjects with Selective IgA Deficiency: From Senior Idea to Novel Opportunities

Soheili

Abolhassani²,

Arandi³

et al. 2012

Int Arch Allergy Immunol

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Background: Selective IgA deficiency (SIgAD) is the most common primary immunodeficiency disorder, which is characterized by significantly decreased serum levels of IgA. Abnormalities of CD4+CD25^highforkhead box P3 (FoxP3)+ regulatory T cells (T_reg) have been shown in association with autoimmune and inflammatory disorders. Methods: In order to evaluate the relationship between autoimmunity and T_reg in SIgAD, we studied 26 IgA-deficient patients (aged 4–17 years) with serum IgA levels <7 mg/dl, 26 age- and sex-matched healthy controls and 26 age- and sex matched idiopathic thrombocytopenic purpura cases with normal immune system. T_reg were determined by flow cytometry using T_reg markers, including CD4, CD25 and FoxP3. Results: The mean percentage of CD4, CD25+FoxP3+ T_reg from all CD4+ cells was 4.08 ± 0.86 in healthy controls, which was significantly higher than in SIgAD patients (2.93 ± 1.3; p = 0.003). We set a cutoff point (2.36%) for T_reg, which was two standard deviations lower than the mean of normal controls. According to this cutoff point and in order to assess the role of T_reg in clinical SIgAD manifestation, we classified patients into two groups: 16 patients in G1 with T_reg <2.36% and 10 patients in G2 with T_reg >2.36%. Autoimmunity was recorded in 9 patients (53.3%) of G1 and only 1 patient of G2, respectively (p = 0.034). Although a defect in class switching recombination was observed in 40% of the patients in G1, none of the G2 patients had such a defect (p = 0.028). Conclusion: This study showed decreased proportions of T_reg in SIgAD patients, particularly in those with signs of chronic inflammation.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Natural Regulatory T Cells in Subjects with Selective IgA Deficiency: From Senior Idea to Novel Opportunities

Soheili

Abolhassani²,

Arandi³

et al. 2012

Int Arch Allergy Immunol

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“…For example, there is a virtual absence of plasma cells in the lamina propria of the rectum of babies until 7-10 days after birth when abrupt colonization with IgA-containing plasma cells occurs in numbers comparable with those seen in the adult (Tomasi and Bienenstock, 1968). Moreover, in germ-free animals there is a marked deficiency of IgA-specific cells in the lamina propria; oral administration of horse spleen ferritin to germ-free mice has been shown to result in a substantial increase in plasma cells containing IgA antibody (Crabbe et al., 1969).…”

Section: Introductionmentioning

confidence: 99%

The Origin of Antibody in Intestinal Secretion of Sheep

Husband

1974

Aust J Exp Biol Med

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Summary. Tbiry and double re-entrant j'ejuiia] loops were prepared in adult sheep and young lambs to study antibody responses following local and systemic administration of soluble and particulate antigens. Systemic administration of both living Brttcclta abortus and ferritin elicited an IgG response in serum and intestinal secretion. Repeated local infusions of living and killed Br. abortus into isolated intestinal loops failed to elicit a significant response. However, local infusions of egg albumin or ferritin resulted in ths appearance in intestinal secretion of substantial amounts of antibody most of which was associated with IgA. The results obtained using lambs demonstrated that local antibody production associated with IgA occurred after antigenic stimulation of intestinal loops in animals as young as 3 weeks of age.INTRODUCTION.

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“…Evidence has been presented both in dogs (43) and mice (44,45) that serum-3'A may be derived in large part from synthesis in cells located in the gastrointestinal tract. The marked suppression of serum-'yA with essentially normal numbers of 3,A-cells in the gut lamina propria observed in anti-3,A-treated animals is at first glance contrary to this hypothesis and would be analogous to the patients that have been reported showing a similar dissociation between serum and secretory "),A (46).…”

Section: Evidence For Runting Syndrome In a Nti-3m-treated Mice--a mentioning

confidence: 99%

PRODUCTION OF a RUNTING SYNDROME AND SELECTIVE ΓA DEFICIENCY IN MICE BY THE ADMINISTRATION OF ANTI-HEAVY CHAIN ANTISERA

Murgita¹,

Mattioli²,

Tomasi³

1973

The Journal of Experimental Medicine

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Conventional Swiss mice were treated from birth with intraperitoneal injections of anti-immunoglobulins in an attempt to create an experimental dysgammaglobulinemia. Mice treated with anti-γM were immunologically suppressed in all immunoglobulin classes as determined by serum antibody titers, splenic plaque-forming cells, serum immunoglobulin levels, and immunofluorescent analysis of plasma cells in lymphoid tissues. Treatment immediately after birth with high concentrations of anti-γM leads to a developmental arrest characterized by severe immunosuppression, failure to gain weight, and premature death. The pathogenesis of anti-γM runting syndrome is unknown. Animals similarly treated with anti-γG, anti-γA, or control normal goat or rabbit γ-globulins developed normally. The frequency of occurrence and severity of anti-γM-induced runting syndrome is dependent upon the concentration of anti-γM-globulin administered. Administration of anti-γA resulted in a selective γA deficiency that was characterized by a marked reduction in serum-γA and an absence of γA-containing cells in the spleen. However, essentially normal numbers of plasma cells were found in the gastrointestinal lamina propria of anti-γA-treated animals concomitantly with suppressed levels of γA in intestinal fluids.

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ANTIBODIES OF THE IgA TYPE IN INTESTINAL PLASMA CELLS OF GERMFREE MICE AFTER ORAL OR PARENTERAL IMMUNIZATION WITH FERRITIN

Cited by 190 publications

References 27 publications

Evaluation of Natural Regulatory T Cells in Subjects with Selective IgA Deficiency: From Senior Idea to Novel Opportunities

Evaluation of Natural Regulatory T Cells in Subjects with Selective IgA Deficiency: From Senior Idea to Novel Opportunities

The Origin of Antibody in Intestinal Secretion of Sheep

PRODUCTION OF a RUNTING SYNDROME AND SELECTIVE ΓA DEFICIENCY IN MICE BY THE ADMINISTRATION OF ANTI-HEAVY CHAIN ANTISERA

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